Franke, prof. dr. Lude
Lude Franke (1980) is adjunct-hoogleraar aan de afdeling Genetica van de Rijksuniversiteit Groningen/Universitair Medisch Centrum Groningen en hoofd Research and Education van de afdeling Genetica aan het UMCG. Als statistisch geneticus richt hij zich op het analyseren van gegevens over de genetica van complexe ziekten en auto-immuunziekten (zoals coeliakie). Dankzij een ERC Starting Grant (2014), een NWO VIDI-beurs (2014), een NWO VENI-beurs (2009) en een Horizon-beurs (2009) kan hij onderzoek uitvoeren naar moleculaire effecten van mutaties die ziektes veroorzaken.
Jonge Akademie, Lude Franke
In zijn vrije tijd is Franke grafisch ontwerper. Deze gelukkige combinatie van vaardigheden kan het leven van een genetisch onderzoeker behoorlijk makkelijker maken: als je je onderzoek visueel kunt uitleggen, begrijpen meer mensen wat je bedoelt. Lude Franke is een van de 'founding members' van de Young Academy Groningen.
In 2021 ontving Franke een Vici subsidie om onderzoek te doen naar genetische mutaties. Kanker wordt vaak veroorzaakt door mutaties die tijdens het leven ontstaan, terwijl andere ziekten worden veroorzaakt door genetische veranderingen die van ouder op kind zijn doorgegeven. Zijn project bestudeert met gen-netwerken of een overkoepeld principe bestaat dat deze verschillende soorten mutaties verenigt.
Eerder in het nieuws
2024
Moerkens,
R., Mooiweer, J.,
Ramírez-Sánchez, A. D., Oelen,
R., Franke, L., Wijmenga, C.,
Barrett, R. J., Jonkers, I. H., & Withoff,
S. (2024). An iPSC-derived small intestine-on-chip
with self-organizing epithelial, mesenchymal, and neural
cells. Cell reports, 43(7),
Article 114247. https://doi.org/10.1016/j.celrep.2024.114247
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S., Ripoll-Cladellas, A., Culinscaia, A., Bulut, O.,
Bourgonje, A. R., Netea, M. G., Lansdorp, P.,
Aubert, G., Bonder, M. J., Franke, L. H.,
Vogl, T., van der Wijst, M. G. P., Melé,
M., van Baarle, D., Fu, J., &
Zhernakova, A. (2024). Antibody signatures against
viruses and microbiome reflect past and chronic exposures and
associate with aging and inflammation.
iScience , 27(6), Article 109981. https://doi.org/10.1016/j.isci.2024.109981
Lifelines
Corona Research initiative, Goërtz, Y. M. J., Spruit, M. A.,
Van Herck, M., Dukers-Muijrers, N., van der Kallen, C. J. H.,
Burtin, C., & Janssen, D. J. A. (2024). Author
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F., Domanegg, K., Zidan, M., Bakker, O.
B., Claringbould, A., de Ridder, J., Zwart,
W., Westra, H. J., Deelen, P.,
& Franke, L. (2024). Co-expression in
tissue-specific gene networks links genes in cancer-susceptibility
loci to known somatic driver genes. BMC Medical
Genomics, 17, Article 186. https://doi.org/10.1186/s12920-024-01941-4
Neavin,
D., Senabouth, A., Arora, H., Lee, J. T. H., Ripoll-Cladellas,
A., Franke, L., Prabhakar, S., Ye, C. J., McCarthy, D.
J., Melé, M., Hemberg, M., & Powell, J. E. (2024).
Demuxafy: improvement in droplet assignment by integrating
multiple single-cell demultiplexing and doublet detection
methods. Genome Biology,
25(1), Article 94. https://doi.org/10.1186/s13059-024-03224-8
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Working Group of the Psychiatric Genomics Consortium, Trastulla,
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profiles define clinically relevant patient strata across common
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J., Palasantzas, V., Andreu-Sánchez,
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S., Bonder, M. J., Westra, H.-J.,
van Meurs, J., Ghanbari, M., Franke, L.,
Zhernakova, A., Fu, J., Hoogerland, J.
A., & Zhernakova, D. V. (2024).
Epigenome-wide association study on the plasma metabolome
suggests self-regulation of the glycine and serine pathway through
DNA methylation. Clinical Epigenetics,
16, Article 104. https://doi.org/10.1186/s13148-024-01718-7
Akeju,
O., Mens, M. M. J., Warmerdam, R., Dijkema, M., van
den Biggelaar, A. H. J., Franke, L., Goudsmit, J.,
& Wu, J. W. (2024). Genetic Correlates of Biological
Aging and the Influence on Prediction of Mortality.
Journals of Gerontology - Series A Biological Sciences
and Medical Sciences, 79(4), Article glae024.
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China
Kadoorie Biobank Collaborative Group, Karjalainen, M. K.,
Karthikeyan, S., Oliver-Williams, C., Sliz, E., Allara, E., Fung,
W. T., Surendran, P., Zhang, W., Jousilahti, P., Kristiansson, K.,
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(2024). Genome-wide characterization of circulating metabolic
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V., Oelen, R., Groot, H. E.,
Benjamins, J. W., Brambs, S., Kaiser, R., Gottschlich, A.,
Hoffmann, G. V., Eivers, L., Martinez-Navarro, A., Bruns, N.,
Stiller, S., Akgöl, S., Yue, K., Polewka, V., ... Stark, K.
(2024). Multiomic analyses uncover immunological signatures
in acute and chronic coronary syndromes. Nature
Medicine, 30, 1696–1710. https://doi.org/10.1038/s41591-024-02953-4
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M., Deelen, J., van Meurs, J. B. J., van Dongen, J., Pool, R.,
Boomsma, D. I., Ghanbari, M., & Franke, L. (2024).
NMR metabolomics-guided DNA methylation mortality
predictors. EBioMedicine,
107, Article 105279. https://doi.org/10.1016/j.ebiom.2024.105279
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Fu, J., Zhernakova, A., Westra,
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principal interaction component analysis for the identification of
discrete technical, cell-type, and environmental factors that
mediate eQTLs. Genome Biology,
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ABCTB
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Vaudel, M., Mendes de Oliveira, E., Messina, A., Walters, R. G.,
Liu, X., Busch, A. S., Helgason, H., Thompson, D. J., Santoni, F.,
Petricek, K. M., Zouaghi, Y., Huang-Doran, I., Gudbjartsson, D. F.,
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Blokland, I. V., Oelen, R., Groot, H.
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Knottenberg, V., Heinig, M., Nicolai, L., Stark, K., van der
Harst, P., Franke, L., & van der
Wijst, M. G. P. (2024). Single-Cell Dissection of the
Immune Response After Acute Myocardial Infarction.
Circulation. Genomic and precision medicine,
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Investigators, Perry, J. R. B., & Ong, K. K. (2024).
Understanding the genetic complexity of puberty timing across
the allele frequency spectrum. Nature
genetics, 56(7), 1397-1411. https://doi.org/10.1038/s41588-024-01798-4
2023
COVID-19
Host Genetics Initiative (2023). A second update on mapping
the human genetic architecture of COVID-19.
Nature, 621(7977), E7-E26. https://doi.org/10.1038/s41586-023-06355-3
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Nature genetics, 55(3), 377-388. https://doi.org/10.1038/s41588-023-01300-6
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Nature, 621(7977), E7-E26. https://doi.org/10.1093/1476-4687
HUNT
All-In Stroke, CADISP group, International Consortium for Blood
Pressure (ICBP), The International Headache Genetics Consortium
(IHGC), International Stroke Genetics Consortium, ISGC Intracranial
Aneurysm Working Group, Bakker, M. K., Kanning, J. P., Abraham, G.,
Martinsen, A. E., Winsvold, B. S., Zwart, J. A., Bourcier, R.,
Sawada, T., Koido, M., Kamatani, Y., Morel, S., Amouyel, P.,
Debette, S., ... Ruigrok, Y. M. (2023). Genetic Risk Score
for Intracranial Aneurysms: Prediction of Subarachnoid Hemorrhage
and Role in Clinical Heterogeneity.
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BBJ,
BioMe, BioVU, Canadian Partnership for Tomorrow's Health/OHS, China
Kadoorie Biobank Collaborative Group, Colorado Center for
Personalized Medicine, deCODE Genetics, ESTBB, FinnGen, Generation
Scotland, Genes & Health, LifeLines, Mass General Brigham
Biobank, Michigan Genomics Initiative, QIMR Berghofer Biobank,
Taiwan Biobank, The HUNT Study, UCLA ATLAS Community Health
Initiative, UKBB, ... Hirbo, J. B. (2023). Global Biobank
analyses provide lessons for developing polygenic risk scores
across diverse cohorts. Cell Genomics,
3(1), Article 100241. https://doi.org/10.1016/j.xgen.2022.100241
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T., de Vries, D. H., Korshevniuk, M., Losert,
C., Oelen, R., van Blokland, I. V.,
Groot, H. E., Swertz, M. A., van der
Harst, P., Westra, H. J., van der Wijst,
M. G. P., Heinig, M., & Franke, L. (2023).
Identification of genetic variants that impact gene
co-expression relationships using large-scale single-cell
data. Genome Biology, 24,
Article 80. https://doi.org/10.1186/s13059-023-02897-x
Boahen,
C. K., Oelen, R., Le, K., Netea,
M. G., Franke, L., Wijst, M. G. P. V.
D., & Kumar, V. (2023). Integration
of Candida albicans-induced single-cell gene expression data and
secretory protein concentrations reveal genetic regulators of
inflammation. Frontiers in Immunology,
14, Article 1069379. https://doi.org/10.3389/fimmu.2023.1069379
Genomics
England Research Consortium, Boulogne, F., Claus, L.
R., Wiersma, H., Oelen, R., Schukking,
F., de Klein, N., Li, S., Westra,
H. J., van der Zwaag, B., van Reekum, F., Sierks, D.,
Schönauer, R., Li, Z., Bijlsma, E. K., Bos, W. J. W.,
Halbritter, J., Knoers, N. V. A. M., Besse, W., ...
van Eerde, A. M. (2023). KidneyNetwork: Using kidney-derived
gene expression data to predict and prioritize novel genes involved
in kidney disease. European Journal of Human
Genetics, 31, 1300–1308. https://doi.org/10.1038/s41431-023-01296-x
BIOS
Consortium, Dekkers, K. F., Slieker, R. C., Ioan-Facsinay, A., van
Iterson, M., Ikram, M. A., van Greevenbroek, M. M. J., Veldink, J.
H., Franke, L., Boomsma, D. I., Slagboom, P. E.,
Jukema, J. W., & Heijmans, B. T. (2023). Lipid-induced
transcriptomic changes in blood link to lipid metabolism and
allergic response. Nature
Communications, 14, Article 544. https://doi.org/10.1038/s41467-022-35663-x
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K., Losert, C., Knottenberg, V., van Blokland, I.
V., Oelen, R., Groot, H. E.,
Benjamins, J. W., Brambs, S., Kaiser, R., Eivers, L.,
Polewka, V., Escaig, R., Joppich, M., Janjic, A., Popp, O.,
Petzold, T., Zimmer, R., Enard, W., Saar, K., ... Stark, K. (2023).
Multi-Omic Factor Analysis uncovers immunological
signatures with pathophysiologic and clinical implications in
coronary syndromes. MedRxiv. https://doi.org/10.1101/2023.05.02.23289392
eQTLgen
Consortium, Dai, Q., Zhou, G., Zhao, H., Võsa,
U., Franke, L., Battle, A., Teumer, A.,
Lehtimäki, T., Raitakari, O. T., Esko, T., Epstein, M. P.,
& Yang, J. (2023). OTTERS: a powerful TWAS framework
leveraging summary-level reference data. Nature
Communications, 14, Article 1271. https://doi.org/10.1038/s41467-023-36862-w
The
Netherlands A. C. M./P. L. N. Registry, Lifelines Cohort
Study, Lopera-Maya, E. A., Li, S.,
de Brouwer, R., Nolte, I. M., van Breen,
J., Jongbloed, J. D. H., Swertz, M.
A., Snieder, H., Franke, L.,
Wijmenga, C., de Boer, R. A., Deelen,
P., van der Zwaag, P. A., & Sanna,
S. (2023). Phenotypic and Genetic Factors Associated
with Absence of Cardiomyopathy Symptoms in PLN:c.40_42delAGA
Carriers. Journal of cardiovascular translational
research, 16, 1251–1266. https://doi.org/10.1007/s12265-022-10347-5
Kellmann,
A., Lanting, P., Franke, L.
H., van Enckevort, E., & Swertz, M.
A. (2023). Semiautomatic translation of medicine usage
data (in Dutch, free-text) from Lifelines COVID-19 questionnaires
to ATC codes. Database-The journal of biological
databases and curation, 2023. https://doi.org/10.1093/database/baad019
ABCTB
Investigators, Kentistou, K. A., Kaisinger, L. R., Stankovic, S.,
Vaudel, M., de Oliveira, E. M., Messina, A., Walters, R. G., Liu,
X., Busch, A. S., Helgason, H., Thompson, D. J., Santon, F.,
Petricek, K. M., Zouaghi, Y., Huang-Doran, I., Gudbjartsson, D. F.,
Bratland, E., Lin, K., ... Ong, K. K. (2023).
Understanding the genetic complexity of puberty timing
across the allele frequency spectrum. MedRxiv. https://doi.org/10.1101/2023.06.14.23291322
Lifelines
Corona Research initiative, Mobach, M. P., Boezen, H.
M., Mierau, J. O., Franke, H.
L., Dekens, J., Deelen, P.,
Lanting, P., Vonk, J. M., Nolte,
I., Ori, A. P. S., Claringbould,
A., Boulogne, F., Dijkema, M. X. L.,
Wiersma, H. H., Warmerdam, R.,
Jankipersadsing, S. A., van Blokland, I.,
de Bock, G. T. H., ... Wijmenga, C. (2023).
Workplace impact on employees: A Lifelines Corona Research
Initiative on the return to work. PLoS
ONE, 18(1), Article e0279902. https://doi.org/10.1371/journal.pone.0279902
2022
COVID-19
Host Genetics Initiative (2022). A first update on mapping
the human genetic architecture of COVID-19.
Nature, 608, E1–E10. https://doi.org/10.1038/s41586-022-04826-7
Lifelines
Cohort Study, Zhernakova, D. V., Sinha,
T., Andreu Sánchez, S., Prins,
J., Kurilshikov, A., Balder, J.-W.,
Sanna, S., Franke, L. H., Kuivenhoven, J.
A., Zhernakova, A., & Fu, J.
(2022). Age-dependent sex differences in cardiometabolic risk
factors. Nature Cardiovascular
Research, 1, 844–854. https://doi.org/10.1038/s44161-022-00131-8
Lifelines
Cohort Study, Lopera-Maya, E. A., Kurilshikov,
A., van der Graaf, A., Hu,
S., Andreu-Sánchez, S., Chen,
L., Vila, A. V., Gacesa, R.,
Sinha, T., Collij, V., Klaassen, M. A.
Y., Bolte, L. A., Gois, M. F. B.,
Neerincx, P. B. T., Swertz, M. A.,
Harmsen, H. J. M., Wijmenga, C., Fu,
J., ... Sanna, S. (2022). Author
Correction: Effect of host genetics on the gut microbiome in 7,738
participants of the Dutch Microbiome Project (Nature Genetics,
(2022), 54, 2, (143-151), 10.1038/s41588-021-00992-y).
Nature genetics, 54(9), 1448. https://doi.org/10.1038/s41588-022-01164-2
SLALOM
Consortium, PARALS Consortium, SLAGEN Consortium, SLAP Consortium,
van Rheenen, W., van der Spek, R. A. A., Bakker, M. K., van Vugt,
J. J. F. A., Hop, P. J., Zwamborn, R. A. J., de Klein,
N., Westra, H.-J., Bakker, O.
B., Deelen, P., Shireby, G., Hannon, E.,
Moisse, M., Baird, D., Restuadi, R., ... Veldink, J. H. (2022).
Author Correction: Common and rare variant association
analyses in amyotrophic lateral sclerosis identify 15 risk loci
with distinct genetic architectures and neuron-specific biology
(vol 53, pg 1636, 2021). Nature
genetics, 54(3), 361-361. https://doi.org/10.1038/s41588-022-01020-3
Lopera-Maya,
E. A., Kurilshikov, A., van der Graaf,
A., Hu, S., Lifelines Cohort Study,
Andreu-Sánchez, S., Chen, L., Vila,
A. V., Gacesa, R., Sinha,
T., Collij, V., Klaassen, M. A. Y.,
Bolte, L. A., Brandao Gois, M. F.,
Neerincx, P. B. T., Swertz, M. A.,
Harmsen, H. J. M., Wijmenga, C., Fu,
J., ... Sanna, S. (2022). Effect of host
genetics on the gut microbiome in 7,738 participants of the Dutch
Microbiome Project. Nature genetics,
54, 143-151. https://doi.org/10.1038/s41588-021-00992-y
BIOS
Consortium (2022). Functional genomics analysis identifies T
and NK cell activation as a driver of epigenetic clock
progression. Genome Biology,
23(1), 24. https://doi.org/10.1186/s13059-021-02585-8
Andreu-Sánchez,
S., Aubert, G., Ripoll-Cladellas, A., Henkelman, S.,
Zhernakova, D. V., Sinha, T.,
Kurilshikov, A., Cenit, M. C., Jan Bonder,
M., Franke, L., Wijmenga,
C., Fu, J., van der Wijst, M. G.
P., Melé, M., Lansdorp, P., &
Zhernakova, A. (2022). Genetic, parental and lifestyle
factors influence telomere length. Communications
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BIOS
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Hannon, E., Shireby, G. L., Nabais, M. F., Walker, E. M., van
Rheenen, W., van Vugt, J. J. F. A., Dekker, A. M., Westeneng, H.
J., Tazelaar, G. H. P., van Eijk, K. R., Moisse, M., Baird, D., Al
Khleifat, A., Iacoangeli, A., Ticozzi, N., ... Veldink, J. H.
(2022). Genome-wide study of DNA methylation shows
alterations in metabolic, inflammatory, and cholesterol pathways in
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14(633), Article eabj0264. https://doi.org/10.1126/scitranslmed.abj0264
deCODE
Genetics, Estonian Biobank, FinnGen, Generation Scotland, Genes
& Health Research Team, LifeLines, Mass General Brigham
Biobank, Michigan Genomics Initiative, National Biobank of Korea,
Penn Medicine BioBank, Qatar Biobank, The QSkin Sun and Health
Study, Taiwan Biobank, The HUNT Study, UCLA ATLAS Community Health
Initiative, Uganda Genome Resource, UK Biobank, Biobank of the
Americas, BioBank Japan Project, ... Sanna, S. (2022).
Global Biobank Meta-analysis Initiative: Powering genetic
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Venema, W. T. C., Ramírez-Sánchez, A.
D., Bigaeva, E., Withoff,
S., Jonkers, I., McIntyre, R. E., Ghouraba, M.,
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L., Festen, E. A. M., & van der
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J. M., Boezen, H. M., Deelen,
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Kroon, M. L. A., Boezen, H. M., Mierau,
J. O., Franke, H. L., Dekens,
J., Deelen, P., Lanting, P.,
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Bios
Consortium , Porcu, E., Claringbould, A., Weihs, A.,
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A., Franke, L., Reymond, A., & Kutalik, Z. (2022).
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fine-mapping is often miscalibrated at single-variant
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M., Claringbould, A., Porcu, E., Kals, M.,
Jürgenson, T., Morris, A. P., Võsa, U.,
Bochud, M., Stringhini, S., Wijmenga, C.,
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