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About us Practical matters How to find us P. (Patrick) Deelen

University Medical Center Groningen

P. (Patrick) Deelen

Faculty of Medical Sciences

Telephone:

E-mail:

p.deelen umcg.nl

Homepage ORCID Research Portal

Research interests

I am primarily interested in improving the diagnostic yield of genome sequencing of patients who have a rare disease. I do this by integrating population genetics and transcriptomics.

Publications

Improving the diagnostic yield of exome-sequencing by predicting gene-phenotype associations using large-scale gene expression analysis

Deelen, P., van Dam, S., Herkert, J. C., Karjalainen, J. M., Brugge, H., Abbott, K. M., van Diemen, C. C., van der Zwaag, P. A., Gerkes, E. H., Zonneveld-Huijssoon, E., Boer-Bergsma, J. J., Folkertsma, P., Gillett, T., van der Velde, K. J., Kanninga, R., van den Akker, P. C., Jan, S. Z., Hoorntje, E. T., Te Rijdt, W. P. & Vos, Y. J.& 7 others, Jongbloed, J. D. H., van Ravenswaaij-Arts, C. M. A., Sinke, R., Sikkema-Raddatz, B., Kerstjens-Frederikse, W. S., Swertz, M. A. & Franke, L., 28-Jun-2019, In: Nature Communications. 10, 1, 13 p., 2837.

Research output: Contribution to journal › Article › Academic › peer-review

Identification of context-dependent expression quantitative trait loci in whole blood

Pital-Zhernakova, D., Deelen, P., Vermaat, M., van Iterson, M., van Galen, M., Arindrarto, W., van 't Hof, P., Mei, H., van Dijk, F., Westra, H.-J., Bonder, M. J., van Rooij, J., Verkerk, M., Jhamai, P. M., Moed, M., Kielbasa, S. M., Bot, J., Nooren, I., Pool, R. & van Dongen, J.& 27 others, Hottenga, J. J., Stehouwer, C. D. A., van der Kallen, C. J. H., Schalkwijk, C. G., Zhernakova, A., Li, Y., Tigchelaar, E. F., de Klein, N., Beekman, M., Deelen, J., van Heemst, D., van den Berg, L. H., Hofman, A., Uitterlinden, A. G., van Greevenbroek, M. M. J., Veldink, J. H., Boomsma, D. I., van Duijn, C. M., Wijmenga, C., Slagboom, P. E., Swertz, M. A., Isaacs, A., van Meurs, J. B. J., Jansen, R., Heijmans, B. T., 't Hoen, P. A. C. & Franke, L., Jan-2017, In: Nature Genetics. 49, 1, p. 139-145 7 p.

Research output: Contribution to journal › Letter › Academic › peer-review

Calling genotypes from public RNA-sequencing data enables identification of genetic variants that affect gene-expression levels

Deelen, P., Zhernakova, D. V., de Haan, M., van der Sijde, M., Bonder, M. J., Karjalainen, J., van der Velde, K. J., Abbott, K. M., Fu, J., Wijmenga, C., Sinke, R. J., Swertz, M. A. & Franke, L., 27-Mar-2015, In: Genome medicine. 7, 1, 13 p., 30.

Research output: Contribution to journal › Article › Academic › peer-review

Low-cost generation of clinical-grade, layperson-friendly pharmacogenetic passports using oligonucleotide arrays

Lifelines NEXT cohort study, 24-Mar-2025, In: American Journal of Human Genetics.

Research output: Contribution to journal › Article › Academic › peer-review

Author Correction: Symptoms and quality of life before, during, and after a SARS-CoV-2 PCR positive or negative test: data from Lifelines (Scientific Reports, (2023), 13, 1, (11713), 10.1038/s41598-023-38223-5)

Lifelines Corona Research initiative, Goërtz, Y. M. J., Spruit, M. A., Van Herck, M., Dukers-Muijrers, N., van der Kallen, C. J. H., Burtin, C. & Janssen, D. J. A., Dec-2024, In: Scientific Reports. 14, 8390.

Research output: Contribution to journal › Erratum

Co-expression in tissue-specific gene networks links genes in cancer-susceptibility loci to known somatic driver genes

Urzúa-Traslaviña, C. G., van Lieshout, T., Boulogne, F., Domanegg, K., Zidan, M., Bakker, O. B., Claringbould, A., de Ridder, J., Zwart, W., Westra, H. J., Deelen, P. & Franke, L., 15-Jul-2024, In: BMC Medical Genomics. 17, 14 p., 186.

Research output: Contribution to journal › Article › Academic › peer-review

Identification of rare disease genes as drivers of common diseases through tissue-specific gene regulatory networks

Bakker, O. B., Claringbould, A., Westra, H. J., Wiersma, H., Boulogne, F., Võsa, U., Urzúa-Traslaviña, C. G., Mulcahy Symmons, S., Zidan, M. M. M., Sadler, M. C., Kutalik, Z., Jonkers, I. H., Franke, L. & Deelen, P., Dec-2024, In: Scientific Reports. 14, 13 p., 30206.

Research output: Contribution to journal › Article › Academic › peer-review

Phenotype prediction using biologically interpretable neural networks on multi-cohort multi-omics data

Bios Consortium , van Hilten, A., van Rooij, J., Ikram, M. A., Niessen, W. J., van Meurs, J. B. J. & Roshchupkin, G. V., Dec-2024, In: npj Systems Biology and Applications. 10, 10 p., 81.

Research output: Contribution to journal › Article › Academic › peer-review

Picalo: principal interaction component analysis for the identification of discrete technical, cell-type, and environmental factors that mediate eQTLs

Vochteloo, M., Deelen, P., Vink, B., Bios Consortium , Tsai, E. A., Runz, H., Andreu-Sánchez, S., Fu, J., Zhernakova, A., Westra, H.-J. & Franke, L., 2024, In: Genome Biology. 25, 1, 29.

Research output: Contribution to journal › Article › Academic › peer-review

Brain expression quantitative trait locus and network analyses reveal downstream effects and putative drivers for brain-related diseases

de Klein, N., Tsai, E. A., Vochteloo, M., Baird, D., Huang, Y., Chen, C. Y., van Dam, S., Oelen, R., Deelen, P., Bakker, O. B., El Garwany, O., Ouyang, Z., Marshall, E. E., Zavodszky, M. I., van Rheenen, W., Bakker, M. K., Veldink, J., Gaunt, T. R., Runz, H. & Franke, L.& 1 others, Westra, H. J., Mar-2023, In: Nature genetics. 55, 3, p. 377-388 12 p.

Research output: Contribution to journal › Article › Academic › peer-review

All (100) publications

Press/media

Did you follow COVID lockdown rules? Whether or not you did is partially driven by your DNA

Deelen, P.

22/08/2022

Press/Media: Expert Comment › Popular

COVID-19: Whether you followed lockdown rules may have been influenced by your genetics

Deelen, P.

23/05/2022

Press/Media: Expert Comment › Popular

Whether you followed lockdown rules may have been influenced by your genetics – new research

Deelen, P.

22/05/2022

Press/Media: Expert Comment › Popular

Followed lockdown rules? It may have been your genetics, says new research

Deelen, P.

22/05/2022

Press/Media: Expert Comment › Popular

Genetic regulation of blood cells: Proximity of a gene to a genetic change plays an important role

Bonder, M. J., Claringbould, A. & Deelen, P.

22/09/2021

Press/Media: Research › Popular

Coronacrisis vergroot de invloed DNA op gedrag en welbevinden

Deelen, P. & Franke, L.

09/06/2021

Press/Media: Expert Comment › Professional

Invloed DNA op gedrag en welbevinden tijdens coronacrisis steeds groter

Deelen, P. & Franke, L.

08/06/2021

Press/Media: Expert Comment › Popular

Opmerkelijk: DNA blijkt van invloed op gedrag en welbevinden tijdens coronacrisis, meldt UMCG

Deelen, P. & Franke, L.

08/06/2021

Press/Media: Expert Comment › Popular

Veni-beurzen voor veertien Groningse onderzoekers

van Borkulo, C., Deelen, P. & Drienovská, I.

05/11/2020

Press/Media: Other › Popular

UMCG’ers ontvangen NWO-Veni van €250.000,-

Deelen, P., van der Hoorn, A. & van Borkulo, C.

05/11/2020

Press/Media: Research › Popular

All (11) press/media

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