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About us Practical matters How to find us dr. D.C.J. Spierings

University Medical Center Groningen

dr. D.C.J. Spierings

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Faculty of Medical Sciences

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E-mail:

d.c.j.spierings umcg.nl

ORCID Research Portal

Research interests

Single cell sequencing, genome instability, structural variations, ageing, stem cells, cancer, immunology

Publications

CDK4 is co-amplified with either TP53 promoter gene fusions or MDM2 through distinct mechanisms in osteosarcoma

Saba, K. H., Difilippo, V., Styring, E., Nilsson, J., Magnusson, L., van den Bos, H., Wardenaar, R., Spierings, D. C. J., Foijer, F., Nathrath, M., Haglund de Flon, F., Baumhoer, D. & Nord, K. H., 25-Sept-2024, In: npj Genomic Medicine. 9, 1, 12 p., 42.

Research output: Contribution to journal › Article › Academic › peer-review

Centrosome amplification primes ovarian cancer cells for apoptosis and potentiates the response to chemotherapy

Edwards, F., Fantozzi, G., Simon, A. Y., Morretton, J.-P., Herbette, A., Tijhuis, A. E., Wardenaar, R., Foulane, S., Gemble, S., Spierings, D. C. J., Foijer, F., Mariani, O., Vincent-Salomon, A., Roman-Roman, S., Sastre-Garau, X., Goundiam, O. & Basto, R., 2024, In: PLOS BIOLOGY. 22, 9, 30 p., e3002759.

Research output: Contribution to journal › Article › Academic › peer-review

Chromosomal instability in aneuploid acute lymphoblastic leukemia associates with disease progression

Molina, O., Ortega-Sabater, C., Thampi, N., Fernández-Fuentes, N., Guerrero-Murillo, M., Martínez-Moreno, A., Vinyoles, M., Velasco-Hernández, T., Bueno, C., Trincado, J. L., Granada, I., Campos, D., Giménez, C., Boer, J. M., den Boer, M. L., Calvo, G. F., Camós, M., Fuster, J. L., Velasco, P. & Ballerini, P.& 6 others, Locatelli, F., Mullighan, C. G., Spierings, D. C. J., Foijer, F., Pérez-García, V. M. & Menéndez, P., 1-Jan-2024, In: EMBO Molecular Medicine. 16, 1, p. 64-92 29 p.

Research output: Contribution to journal › Article › Academic › peer-review

Chronic spindle assembly checkpoint activation causes myelosuppression and gastrointestinal atrophy

Karbon, G., Schuler, F., Braun, V. Z., Eichin, F., Haschka, M., Drach, M., Sotillo, R., Geley, S., Spierings, D. C., Tijhuis, A. E., Foijer, F. & Villunger, A., 28-May-2024, In: Embo Reports. 25, p. 2743-2772 30 p.

Research output: Contribution to journal › Article › Academic › peer-review

Correction to: Genome-wide forward genetic screening to identify receptors and proteins mediating nanoparticle uptake and intracellular processing

Montizaan, D., Bartucci, R., Reker-Smit, C., de Weerd, S., Åberg, C., Guryev, V., Spierings, D. C. J. & Salvati, A., 14-Sept-2024, In: Nature Nanotechnology. 19, 9, p. 1419 1 p.

Research output: Contribution to journal › Erratum

Disruption of the TP53 locus in osteosarcoma leads to TP53 promoter gene fusions and restoration of parts of the TP53 signalling pathway

Saba, K. H., Difilippo, V., Kovac, M., Cornmark, L., Magnusson, L., Nilsson, J., van den Bos, H., Spierings, D. C., Bidgoli, M., Jonson, T., Sumathi, V. P., Brosjö, O., Staaf, J., Foijer, F., Styring, E., Nathrath, M., Baumhoer, D. & Nord, K. H., Feb-2024, In: The Journal of Pathology. 262, 2, p. 147-160 14 p.

Research output: Contribution to journal › Article › Academic › peer-review

Drug-resilient cancer cell phenotype is acquired via polyploidization associated with early stress response coupled to HIF-2α transcriptional regulation

Carroll, C., Manaprasertsak, A., Boffelli Castro, A., van den Bos, H., Spierings, D. C. J., Wardenaar, R., Bukkuri, A., Engström, N., Baratchart, E., Yang, M., Biloglav, A., Cornwallis, C., Johansson, B., Hagerling, C., Arsenian-Henriksson, M., Paulsson, K., Amend, S. R., Mohlin, S., Foijer, F. & McIntyre, A.& 2 others, Pienta, K. J. & Hammarlund, E. U., 7-Mar-2024, In: Cancer research communications. 4, 3, p. 691–705 15 p.

Research output: Contribution to journal › Article › Academic › peer-review

Early evolutionary branching across spatial domains predisposes to clonal replacement under chemotherapy in neuroblastoma

Karlsson, J., Yasui, H., Mañas, A., Andersson, N., Hansson, K., Aaltonen, K., Jansson, C., Durand, G., Ravi, N., Ferro, M., Yang, M., Chattopadhyay, S., Paulsson, K., Spierings, D., Foijer, F., Valind, A., Bexell, D. & Gisselsson, D., Dec-2024, In: Nature Communications. 15, 19 p., 8992.

Research output: Contribution to journal › Article › Academic › peer-review

Extra centrosomes delay DNA damage-driven tumorigenesis

Braun, V. Z., Karbon, G., Schuler, F., Schapfl, M. A., Weiss, J. G., Petermann, P. Y., Spierings, D. C. J., Tijhuis, A. E., Foijer, F., Labi, V. & Villunger, A., 29-Mar-2024, In: Science Advances. 10, 13, 16 p., eadk0564.

Research output: Contribution to journal › Article › Academic › peer-review

Genome-wide forward genetic screening to identify receptors and proteins mediating nanoparticle uptake and intracellular processing

Montizaan, D., Bartucci, R., Reker-Smit, C., Weerd, de, S., Åberg, C., Guryev, V., Spierings, D. & Salvati, A., Jul-2024, In: Nature Nanotechnology. 19, p. 1022-1031 10 p.

Research output: Contribution to journal › Article › Academic › peer-review

All (107) publications

Press/media

Death receptors in normal and malignant tissues

Spierings, D.

14/03/2004

Press/Media: Expert Comment › Professional

All (1) press/media

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