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Over ons Praktische zaken Waar vindt u ons dr. D.C.J. Spierings

Research interests

Single cell sequencing, genome instability, structural variations, ageing, stem cells, cancer, immunology

Publicaties

CDK4 is co-amplified with either TP53 promoter gene fusions or MDM2 through distinct mechanisms in osteosarcoma

Centrosome amplification primes ovarian cancer cells for apoptosis and potentiates the response to chemotherapy

Chromosomal instability in aneuploid acute lymphoblastic leukemia associates with disease progression

Chronic spindle assembly checkpoint activation causes myelosuppression and gastrointestinal atrophy

Correction to: Genome-wide forward genetic screening to identify receptors and proteins mediating nanoparticle uptake and intracellular processing

Disruption of the TP53 locus in osteosarcoma leads to TP53 promoter gene fusions and restoration of parts of the TP53 signalling pathway

Drug-resilient cancer cell phenotype is acquired via polyploidization associated with early stress response coupled to HIF-2α transcriptional regulation

Early evolutionary branching across spatial domains predisposes to clonal replacement under chemotherapy in neuroblastoma

Extra centrosomes delay DNA damage-driven tumorigenesis

Genome-wide forward genetic screening to identify receptors and proteins mediating nanoparticle uptake and intracellular processing

Pers/media

Death receptors in normal and malignant tissues