Publications 2015

Below you will find the publications of the department of Pharmaceutical Biology for 2015. The title of the publication links automatically to the PDF-file (when available).

Baas B-J, Poddar H, Geertsema EM, Rozeboom HJ, de Vries M, Permentier HP, Thunnissen AMWH, Poelarends GJ Functional and Structural Characterization of an Unusual Cofactor-Independent Oxygenase. Biochemistry 54(5):1219-1232.

de Villiers J, de Villiers M, Geertsema EM, Raj H, Poelarends GJ. Chemoenzymatic Synthesis of ortho-, meta-, and para-Substituted Derivatives of L-threo-3-Benzyloxyaspartate, An Important Glutamate Transporter Blocker. ChemCatChem. 2015 Jul 3;7(13):1931-1934. Available from: 10.1002/cctc.201500318

Guan, Z., Xue, D., Abdallah, I..I, Dijkshoorn, L., Setroikromo, R., Lv, G., Quax, W.J. Metabolic engineering of Bacillus subtilis for terpenoid production. Applied Microbiology and Biotechnology. 2015. DOI: 10.1007/s00253-015-6950-1.

Miao Y, Rahimi M, Geertsema EM, Poelarends GJ. Recent developments in enzyme promiscuity for carbon-carbon bond-forming reactions. Current Opinion in Chemical Biology. 25C:115-123.

Müller JEN, Meyer F, Litsanov B, Kiefer P, Potthoff E, Heux S, Quax WJ, Wendisch VF, Brautaset T, Portais JC, Vorholt JA. ,Engineering Escherichia coli for methanol conversion. Metabolic Engineering 28C:190-201.

O'Leary, L., van der Sloot, A.M. Reis, C.R., Deegan, S., Ryan, A.E., Dhami, S.P.S., Murillo, L.S., Cool, R.H., Correa de Sampaio, P., Thompson, K., Murphy, G., Quax, W.J., Serrano, L., Samali, A. and Szegezdi, E. Decoy receptors block TRAIL sensitivity at a supracellular level: the role of stromal cells in controlling tumour TRAIL sensitivity. Oncogene (2015) 1 – 10;

DOI: http://dx.doi.org/ 10.1038/onc.2015.180

Ourailidou ME, Dockerty P, Witte M, Poelarends GJ, Dekker FJ. Metabolic alkene labeling and in vitro detection of histone acylation via the aqueous oxidative Heck reaction.  Org. Biomol. Chem., 2015, 13, 3648–3653

Poddar H, Rahimi M, Geertsema E, Thunnissen A, Poelarends G. Evidence for the Formation of an Enamine Species during Aldol and Michael-type Addition Reactions Promiscuously Catalyzed by 4-Oxalocrotonate Tautomerase. Chembiochem 16(5):738-41

Wójcik M, Telzerow A, Quax WJ, Boersma YL. High-Throughput Screening in Protein Engineering: Recent Advances and Future Perspectives. Int J Mol Sci. 16(10): 24918-45.

doi: 10.3390/ijms161024918.

Xue D, Abdallah II, de Haan IEM, Sibbald MJJB, Quax WJ. Enhanced C30 carotenoid production in Bacillus subtilis by systematic overexpression of MEP pathway genes. Applied Microbiology and Biotechnology. Appl Microbiol Biotechnol DOI 10.1007/s00253-015-6531-3

Theses

Miao, Y. Exploiting Catalytic Promiscuity for Biocatalysis. Carbon-Carbon Bond Formation by a Proline-Based Tautomerase

June 5, 2015

ISBN: 978-94-6182-563-6 (printed version)

ISBN: 978-94-6182-566-7 (electronic version)

Muntendam, R. Metabolomics and bioanalysis of terpenoid derived secondary metabolites: Analysis of Cannabis sativa L. metabolite production and prenylases for cannabinoid production

September 11, 2015

ISBN: 978-94-6259-797-6 (printed version)

Bosman, M.C.J. Dysregulation of survival and apoptosis pathways in acute myeloid leukemia. Targeting of NF-κB in AML

October 7, 2015

ISBN: 978-90-367-8126-8 (printed version)

ISBN: 978-90-367-8125-1 (electronic version)