Publicaties 1999

Articles

Atopkina, L.N., Malinovskaya, G.V.,Elyakov G.B., Uvarova, N.I.,Woerdenbag, H.J., Koulman, A.,Pras, N., Potier, P. Cytotoxicity of natural ginseng glycosides and semisynthetic analogues. Planta Med.,65: 30-34.

Bolhuis, A., Matzen, A., Hyyryläinen, H.-L., Kontinen, V.P., Meima, R.,Chapuis, J., Venema, G., Bron, S.,Freudl, R., Dijl, J.M. van. Signal peptide peptidase- and ClpP-like proteins of Bacillus subtilis required for efficient translocation and processing of secretory proteins. J. Biol. Chem., 274(35): 24585-24592.

Bolhuis, A., Venema, G., Quax, W.J., Bron, S., Dijl. J.M. van. Functional analysis of paralogous thiol-disulfide oxido-reductases in Bacillus subtilis. J. Biol. Chem.,274(35): 24531-24538.

Bolhuis, A., Tjalsma, H., Smith, H.E.,Jong, A. de, Meima, R., Venema, G.,Bron, S., Dijl. J.M. van. Evaluation of bottlenecks in the late stages of protein secretion in Bacillus subtilis. Appl.. Environ. Microbiol.,65 (7): 2934-2941.

Bolhuis, A., Tjalsma, H., Stephenson, K.,Harwood, C.R., Venema, G., Bron, S.,Dijl, J.M. van. Different mechanisms for thermal inactivation of Bacillus subtilis signal peptidase mutants. J. Biol. Chem.,274 (22): 15865-15868.

Bouwmeester, H J , Wallaart, T E, Janssen, M H A , Loo, B van, Jansen, B J M , Posthumus, M A , Schmidt, C O , Kraker, J-W De, König, W A, Franssen, M C R , Amorpha-4,11diene synthase catalyses the first probable step in artemisinin biosynthesis, In: Phytochemistry, 52, pp. 843-854

Braun, P.G. Gerritse, G., Dijl, J.M. van,Quax, W.J. Improving protein secretion by engineering components of the bacterial translocation machinery. Current Opinion in Biotechnology., 10(4):376-381.

Bron, S, Dijl, J M van, Engineering of Bacillus subtilis for the production of secretory proteins, In: BIOforum International, 3, pp. 103-105

Horsten, S.F.A.J., Woerdenbag, H.J. De zaagtandpalm schiet te hulp. Sabal, fytotherapeuticum bij benigne prostaat hyperplasie. Pharm. Weekbl.,134(18): 647-651.

Koulman, A., Pruijn, L.M.C.,Sandstra, T.S.A., Woerdenbag, H.J.,Pras, N. The pharmaceutical exploration of cold water ascidians from the Netherlands: a possible source of new cytotoxic natural products. J. Biotechnology,70: 85-88.

W.J. Quax. Recepten uit de natuur. Pharm. Weekbl., 134(20): 696-699.

Quax, W J, Recepten uit de Natuur, In: Medisch Contact, 54, nr. 16, 1999, pp. 570-573

Tjalsma, H., Kontinen, V.P., Prágai, Z.,Wu, H., Meima, R., Venema, G., Bron, S.,Sarvas, M., Dijl, J.M. van. The role of lipoprotein processing by signal peptidase II in the gram-positive eubacterium Bacillus subtilis (Signal peptidase II is required for the efficient secretion of a-amylase, A non-lipoprotein). J. Biol. Chem., 274 (3): 1698-1707.

Tjalsma, H., Dolder, J. van den, Meijer,W.J.J., Venema, G., Bron, S., Dijl,J.M. van. The plasmid-encoded signal peptidase SipP can functionally replace the major signal peptidases SipS and SipT of Bacillus subtilis. J. Bacteriol.,181 (8): 2448-2454.

Tjalsma, H., Zanen, G.E., Venema, G.,Bron, S., Dijl, J.M. van. The potential active site of the lipoprotein-specific (type II) signal peptidase of Bacillus Subtilis. J. Biol. Chem., 274(40): 28191-28197.

Verhaert, R.M.D., Duin, J. van,Quax, W.J. Processing and functional display of the 86 kDa heterodimeric penicillin G acylase on the surface of phage fd. Biochem. J.,342: 415-422.

Wallaart, T E, Pras, N, Quax, W J, Seasonal variations of artemisinin and its biosynthetic precursors in tetraploid Artemisia annua plants compared with the diploid wild-type, In: Planta Medica, 65, pp. 723-728

Wallaart, T.E., Pras, N., Quax, W.J. Isolation and identification of dihydroartemisinic acid hydroperoxide from Artemisia annua: A novel biosynthtic precursor of artemisinin. J. Nat. Prod., 62(3): 430-433.

Wallaart, T E, Pras, N, Quax, W J, Isolation and identification of dihydroartemisinic acid hydroperoxide from Artemisia annua: A novel biosynthetic precursor of artemisinin, In: Journal of Natural Products, 62, nr. 8, pp. 1160-1162

Wely, K H M van, Swaving, J, Broekhuizen, C P, Rose, M, Quax, W J, Driessen, A J M, Functional identification of the product of the Bacillus subtilis yvaL gene as a SecG homologue, In: Journal of Bacteriology, 181, nr. 6, pp. 1786-1792

Woerdenbag, H.J., Moving, K.L.L.,Egberts, A.C.G. De veiligheid van "intrigerende middelen". Zelfmedicatie bij erectiële disfunctie. Pharm.Weekbl., 134(1): 39-43.

Woerdenbag, H.J. Farmacotherapie met ginkgo: veilig en effectief? Tijdschrift voor Fytotherapie,12: 9-12.

Book chapters

Bron, S., Meima, R., Dijl, J.M. van,Wipat, A., Harwood, C. Molecular biology and genetics of Bacillus species. In: The Manual of industrial microbiology and biotechnology 2nd edition (A.L. Demain and J.E. Davids, eds.) ASM Press, USA. pp 392-416.

Pras, N, Woerdenbag, H J, Production of secondary metabolites by bioconversion, In: Ramawat, K G, Merillon , J M (red), Biotechnology-Secondary Metabolites, Science Publishers, U.S.A. pp. 265-305

Quax, W J, Exploration and optimisation of enzyme secretion by Pseudomonas cells, In: Griengl, H, Steiner, W, Preisz, A, Keil, C (red), Cell Factory Area within the biotechnology programme, pp. 289-292

Quax, W.J. Recepten uit de Natuur, Oratie Rijksuniversiteit Groningen, 16 maart 1999.

Patents

Bertola, M.A., Marx, A.F., Koger, H.S., Quax, W.J., Laken, C.J. van der, Philips, G.T., Robertson, B.W., Watts, P.D. Process for the preparation of 2-arylpropionic acids. EP0426656B1 1999.

Dijl, J.M. van, Smith H.E., Bron, S., Quax, W.J. Improved processing of proteins. EP0444759B1 1999.

Laan, J.M. van der, Riemens, A.M., Quax, W.J. Mutated penicillin G acylase genes.US005891703A 1999.

Quax, W.J., Misset, O., Laan, J.M. van der, Lenting, H.B.M. Mutated ß-lactam acylase genes. US005935831A 1999.

Quax, W.J. Increasing production of proteins in gram-positive microorganisms. WO09904007A1 1999.

Quax, W.J., Caldwell, R.M. Increasing production of proteins in gram-positive microorganisms. WO09904019A1 1999.

Quax, W.J., Caldwell, R.M. Increasing production of proteins in gram-positive microorganisms. WO09904006A1 1999.