Publicaties 2013

Hieronder vindt u de publicaties van de basiseenheid Farmaceutische Biologie in 2013. Indien u op een titel klikt, dan wordt u (indien mogelijk) automatisch naar de publicatie doorgelinked.

Azijli, K., Yuvaraj, S., van Roosmalen, I., Flach, K., Giovannetti, E., Peters, G.J., de Jong, S. and Kruyt, F.A. MAPK p38 and JNK have opposing activities on TRAIL-induced apoptosis activation in NSCLC H460 cells that involves RIP1 and caspase-8 and is mediated by Mcl-1. Apoptosis. 18, 851-860.

Baas, B.J., Zandvoort, E., Geertsema, E.M., and Poelarends, G.J. Recent advances in the study of enzyme promiscuity in the tautomerase superfamily. ChemBioChem. 14: 917-926.

Bosman, M.C., Reis, C.R., Schuringa, J.J., Vellenga, E. and Quax, W.J. Decreased Affinity of Recombinant Human Tumor Necrosis Factor-related Apoptosis-inducing Ligand (rhTRAIL) D269H/E195R to Osteoprotegerin (OPG) Overcomes TRAIL Resistance Mediated by the Bone Microenvironment. doi: 10.1074/jbc.M113.491589 originally published online November 26, 2013.

Bosman MC , Schuringa JJ , Quax WJ , Vellenga E. Bortezomib sensitivity of acute myeloid leukemia CD34+ cells can be enhanced by targeting the persisting activity of NF-κB and the accumulation of MCL-1. Exp Hematol. 41(6): 530-538.

Crismaru, C.G., Wybenga, G.G., Szymański, W., Wijma, H.J., Wu, B., Bartsch, S., de Wildeman, S., Poelarends, G.J., Feringa, B.L., Dijkstra, B.W., and Janssen, D.B. Biochemical properties and crystal structure of a β-phenylalanine aminotransferase from Variovorax paradoxus. Appl. Environ. Microbiol. 79:185-195.

Geertsema, E.M., Miao, Y., Tepper, P.G., de Haan, P., Zandvoort, E., Poelarends, G.J. Biocatalytic Michael-type additions of acetaldehyde to nitroolefins with the proline-based enzyme 4-oxalocrotonate tautomerase yielding enantioenriched γ-nitroaldehydes. Chem, Eur. J, 19, 14407-14410.

Gruchattka, E., Hadicke, O., Klamt, S., Schutz, V. and Kayser, O. In silico profiling of Escherichia coli and Saccharomyces cerevisiae as terpenoid factories. Microb.Cell.Fact. 12, 84-2859-12-84.

Guo, Y., Serrano, H., Poelarends, G.J., Johnson, W.H., Jr., Hackert, M.L., and Whitman, C.P. Kinetic, mutagenic, and structural analysis of malonate semialdehyde decarboxylase from coryneform bacterium strain FG41: Mechanistic implications for the decarboxylase and hydratase activities. Biochemistry 52:4830-4841.

Happyana, N., Agnolet, S., Muntendam, R., Dam, A. van, Schneider, B., Kayser, O. Analysis of cannabinoids in laser-microdissected trichomes of medicinal Cannabis sativa using LCMS and cryogenic NMR. Phytochemistry 87, 51-59.

Meijer, A., Kruyt, F.A., van der Zee, A.G., Hollema, H., Le, P., Ten Hoor, K.A., Groothuis, G.M., Quax, W.J., de Vries, E.G. and de Jong, S. Nutlin-3 preferentially sensitises wild-type p53-expressing cancer cells to DR5-selective TRAIL over rhTRAIL. Br.J.Cancer. 109(10):2685-95.

Melillo E, Setroikromo, R., Quax W.J., Kayser, O. Production of alpha-cuprenene in Xanthophyllomyces dendrorhous: a step closer to a potent terpene biofactory. .Microbial Cell Factories, 12:13.

Miao, Y., Geertsema, E.M., Tepper, P.G., Zandvoort, E., and Poelarends, G.J. Promiscuous catalysis of asymmetric Michael-type additions of linear aldehydes to β-nitrostyrene by the proline-based enzyme 4-oxalocrotonate tautomerase. ChemBioChem. 14: 191-194.

Papaioannou, E., Utari, P.D., Quax, W.J. Choosing an appropriate infection model to study quorum sensing. Int. J. Mol. Sci. 14(9):19309-19340.

Poelarends, G.J., Serrano, H., Huddleston, J.P., Johnson, W.H., Jr., and Whitman, C.P. A mutational analysis of active site residues in trans-3-chloroacrylic acid dehalogenase. FEBS lett. 587:2842-2850.

Puthan Veetil, V., Raj, H., de Villiers, M., Tepper, P.G., Dekker, F.J., Quax, W.J., and Poelarends, G.J. Enantioselective synthesis of N-substituted aspartic acids using an engineered variant of methylaspartate ammonia lyase. ChemCatChem. 5:1325-1327.

Raj, H., and Poelarends, G.J. The roles of active site residues in the catalytic mechanism of methylaspartate ammonia-lyase. FEBS Open Bio 3:285-290

Raj, H., Szymanski, W., de Villiers, J., Puthan Veetil, V., Quax, W.J., Shimamoto, K., Janssen, D.B., Feringa, B.L., and Poelarends, G.J.  Kinetic resolution and stereoselective synthesis of 3-substituted aspartic acids using engineered methylaspartate ammonia lyases. Chem. Eur. J. 19:11148-11152.

Staniek, A., Bouwmeester, H., Fraser, P.D., Kayser, O., Martens, S., Tissier, A., van der Krol, S., Wessjohann, L. and Warzecha, H. Natural products - modifying metabolite pathways in plants. Biotechnol.J. Germany 8, 1159-1171.

Utari, P.D. and Quax, W.J. Caenorhabditis elegans reveals novel Pseudomonas aeruginosa virulence mechanism. Trends in Microbiology 2: 315-316.

Wahjudi M., Murugappan S., Merkerk Ronald van, Eissens A.C., Visser M.R., Hinrichs W.L.J., Quax, W.J. Development of a dry, stable and inhalable acyl–homoserine–lactone–acylase powder formulation for the treatment of pulmonary Pseudomonas aeruginosa infections. European Journal of Pharmaceutical Sciences 48, 637-643.

Wilffert, D., Reis, C.R., Hermans, J., Govorukhina, N., Tomar, T., de Jong, S., Quax, W.J., van de Merbel, N.C. and Bischoff, R. Antibody-Free LC-MS/MS Quantification of rhTRAIL in Human and Mouse Serum. Anal.Chem. Nov 1. [Epub ahead of print].

Proefschriften

Melillo, E. Xanthophyllomyces dendrorhous as a platform organism for the production of terpenes. 1 Maart 2013

ISBN: 978-90-367-6037-9 (gedrukte versie)

ISBN: 978-90-367-6036-2 (elektronische versie).

Wasiel, A.A. Macrophage migration inhibitory factor: cell surface receptor, enzymatic activities, and evolutionary history of a multifunctional cytokine. 19 April 2013.

ISBN: 978-90-367-6152-9 (gedrukte versie)

Raj, H. Engineering and Biocatalytic Applications of Methylaspartate Ammonia Lyase. Asymmetric synthesis of aspartic acid derivatives, 11 oktober 2013.

ISBN: 978-90-367-6455-1 (gedrukte versie)

ISBN: 978-90-367-6454-4 (elektronische versie)

Patenten:

NOVEL METHANOL DEHYDROGENASE ENZYMES FROM BACILLUS.

Brautaset, T., Heggeset, T.M.B., Krog, A., Quax, W.J., Sibbald, M.J.J.B., Vorholt, J., Müller, J., Kiefer, P., Potthoff, E., Wendisch V.F.

Publicatiedatum: 2013/8/2

Patentnummer: WO 2013110797

Hoofdstuk in boek

Quax, W.J. Bacterial enzymes. In: The prokaryotes - Applied Bacteriology and Biotechnology. E. Rosenberg et al. (Eds.), p 193-211. DOI 10.1007/978-3-642-31331-8_26. Springer-Verlag Berlin Heidelberg 2013.