Publications 2012

Below you will find the publications of the department of Pharmaceutical Biology for 2012. The title of the publication links automatically to the PDF-file (when available).

Azijli, K., Yuvaraj, S., Peppelenbosch, M.P., Wurdinger, T., Dekker, H., Joore, J., van Dijk, E., Quax, W.J., Peters, G.J., de Jong, S. and Kruyt, F.A. ( Kinome profiling of non-canonical TRAIL signaling reveals RIP1-Src-STAT3 dependent invasion in resistant non-small cell lung cancer cells. J.Cell.Sci. Epub ahead of print.

Crismaru, C.G., Wybenga, G.G., Szymański, W., Wijma, H.J., Wu, B., Bartsch, S., de Wildeman, S., Poelarends, G.J., Feringa, B.L., Dijkstra, B.W., and Janssen, D.B. Biochemical properties and crystal structure of a β-phenylalanine aminotransferase from Variovorax paradoxus. Appl. Environ. Microbiol., accepted for publication.

de Villiers, M., Puthan Veetil, V., Raj, H., de Villiers, J., and Poelarends, G.J.  Catalytic mechanisms and biocatalytic applications of aspartate and methylaspartate ammonia lyases. ACS Chem. Biol. 7: 1618-1628.

Godinho, L.F., Reis, C.R., Rozeboom, H.J., Dekker, F.J., Dijkstra, B.W., Poelarends, G.J. and Quax, W.J. Enhancement of the enantioselectivity of carboxylesterase A by structure-based mutagenesis. J.Biotechnol. 158, 36-43.

Godinho, L.F., Reis, C.R., Rozeboom, H.J., Dekker, F.J., Dijkstra, B.W., Poelarends, G.J. and Quax, W.J. Enhancement of the enantioselectivity of carboxylesterase A by structure-based mutagenesis. J.Biotechnol. 158, 36-43.

Hendrawati, O., Hille, J., Woerdenbag, H.J., Quax, W.J. and Kayser, O.  In vitro regeneration of wild chervil (Anthriscus sylvestris L.). In Vitro Cell.Dev.Biol.Plant, .48, 355-361.

Krzeslak, J., Papaioannou, E., van Merkerk, R., Paal, K.A., Bischoff, R., Cool, R.H. and Quax, W.J. Lipase A gene transcription in Pseudomonas alcaligenes is under control of RNA polymerase sigma54 and response regulator LipR. FEMS Microbiol Lett, 329, 146-153.

Limsuwan, S., Kayser, O. and Voravuthikunchai, S.P. Antibacterial Activity of Rhodomyrtus tomentosa (Aiton) Hassk. Leaf Extract against Clinical Isolates of Streptococcus pyogenes. Evid Based.Complement.Alternat Med. 697183.

Meijer, A., Kruyt, F.A.E., Meersma G.J., Quax, W.J., Van der Zee, A.G.J., Van Scheltinga, A.G.T., De Vries, E.G.E., De Jong, S. 19 Targeting Cellular Resistance Against Cisplatin-Induced Apoptosis. European Journal of Cancer 48, 9 pages.

Melillo, E., Muntendam, R., Quax, W.J. and Kayser, O., Heterologous expression of pentalenene synthase (PSS) from Streptomyces UC5319 in Xanthophyllomyces dendrorhous. J.Biotechnol., 161, 302-307.

Miao, Y., Geertsema, E.M., Tepper, P.G., Zandvoort, E., and Poelarends, G.J. Promiscuous catalysis of the asymmetric Michael-type addition of linear aldehydes to β-nitrostyrene by the proline-based enzyme 4-oxalocrotonate tautomerase. ChemBioChem., accepted for publication.

Nadal Jimenez, P., Koch, G., Thompson, J.A., Xavier, K.B., Cool, R.H. and Quax, W.J., The Multiple Signaling Systems Regulating Virulence in Pseudomonas aeruginosa. Microbiol.Mol.Biol.Rev. 76, 46-65.

Puthan Veetil, V., Fibriansah, G., Raj, H., Thunnissen, A.-M.W.H., and Poelarends, G.J. The aspartase/fumarase superfamily: a common catalytic strategy involving general base-catalyzed formation of a highly stabilized aci- carboxylate intermediate. Biochemistry, 51, 4237-4243.

Raj, H., Szymański , W.,  de Villiers, J., Rozeboom, H.J., Puthan Veetil, V.,  Reis , C.R., de Villiers, M., Dekker, F.J., de Wildeman, S.,  Quax, W.J., Thunnissen, A.-M.W.H., Feringa, B.L., Janssen, D.B., and Poelarends, G.J.  Engineering methylaspartate ammonia lyase for the asymmetric synthesis of unnatural amino acids. Nat. Chem., 4, 478-484.

Raj, H., Puthan Veetil, V., Szymański, W., Dekker, F.J., Quax, W.J., Feringa, B.L., Janssen, D.B., and Poelarends, G.J. Characterization of a thermostable methylaspartate ammonia lyase from Carboxydothermus hydrogenoformans. Appl. Microbiol. Biotechnol. 94, 385-397.

Szegezdi, E., van der Sloot, A.M., Mahalingam, D., O'Leary, L., Cool, R.H., Munoz, I.G., Montoya, G., Quax, W.J., de Jong, S., Samali, A. and Serrano, L.  Kinetics in signal transduction pathways involving promiscuous oligomerizing receptors can be determined by receptor specificity: Apoptosis induction by TRAIL. Mol.Cell.Proteomics. Mar;11(3):M111.013730. Epub 2012 Jan 2.

Wahjudi, M., Murugappan, S., van Merkerk, R., Eissens, A.C., Visser, M.R., Hinrichs, W.L. and Quax, W.J. Development of a dry, stable and inhalable acyl-homoserine-lactone-acylase powder formulation for the treatment of pulmonary Pseudomonas aeruginosa infections. Eur.J.Pharm.Sci. 48, 637-643.

Wasiel, A.A., Baas, B.J., Zandvoort, E., Quax, W.J. and Poelarends, G.J. Dehalogenation of an anthropogenic compound by an engineered variant of the mouse cytokine macrophage migration inhibitory factor. ChemBioChem.  13, 1270-1273.

Wu, B., Szymański, W., Wybenga, G.G., Heberling, M.M., Bartsch, S., de Wildeman, S., Poelarends, G.J., Feringa, B.L., Dijkstra, B.W., and Janssen, D.B. Mechanism-inspired engineering of phenylalanine aminomutase for enhanced β-regioselective asymmetric amination of cinnamates. Angew. Chem. Int. Ed., 51, 482-486.

Zandvoort, E., Geertsema, E.M., Baas, B.J., Quax, W.J. and Poelarends, G.J. Bridging between organocatalysis and biocatalysis: asymmetric addition of acetaldehyde to beta-nitrostyrenes catalyzed by a promiscuous proline-based tautomerase. Angew.Chem.Int.Ed, 51,1240-1243.

Zandvoort, E., Geertsema, E.M., Quax, W.J., and Poelarends, G.J. Enhancement of the promiscuous aldolase and dehydration activities of 4-oxalocrotonate tautomerase by protein engineering. ChemBioChem., 13, 1274-1277.

Zandvoort, E., Geertsema, E.M., Baas, B.J., Quax, W.J. and Poelarends, G.J. An unexpected promiscuous activity of 4-oxalocrotonate tautomerase: The cis-trans isomerisation of nitrostyrene. ChemBioChem., 13, 1869-1873.

Theses

Wahjudi, M. Combating Gram-negative-infectious diseases: controlling virulence factors through quorum quenching acylases of Pseudomonas aeruginosa. 9 juli 2012.

ISBN: 978-90-367-5609-9 (printed version).

Puthan Veetil, V. Characterization and biocatalytic applications of aspartate and methylaspartate ammonia lyases. 13 juli 2012.

ISBN: 978-90-367-5605-1 (printed version).

Zandvoort, E. Catalytic promiscuity of 4-oxalocrotonate tautomerase. Discovery and characterization of C-C bond-forming activities. 7 december 2012.

ISBN: 978-90-367-5778-2 (printed version).

ISBN: 978-90-367-5777-5 (electronic version).

Patents

TNF FAMILY LIGAND VARIANTS

Assen, Aart H.G. van, Cool Robbert H., Quax, Wilhelmus Johannes, Serrano, Luis, Tur, Vicente R, Van der Sloot, Albert Martinus.

International Publication Number and Date: WO2012085891 (A2), 2012-06-28

TNF FAMILY LIGAND VARIANTS

Assen, Aart H.G. van, Cool Robbert H., Quax, Wilhelmus Johannes, Serrano, Luis, Tur, Vicente R, Van der Sloot, Albert Martinus.

2012/06/27/ PB - EP Patent 2,468,764 ER