Publications 2011

Below you will find the publications of the department of Pharmaceutical Biology for 2011. The title of the publication links automatically to the PDF-file (when available)

Baas, B.J., Zandvoort, E., Wasiel, A.A., Quax, W.J. and Poelarends, G.J. Characterization of a newly identified mycobacterial tautomerase with promiscuous dehalogenase and hydratase activities reveals a functional link to a recently diverged cis-3-chloroacrylic acid dehalogenase. Biochemistry 50, 2889-2899.

Duiker, E.W., de Vries, E., Mahalingam, D., Meersma, G.J., Lub-de Hooge, M.N., Cool, R.H., Quax, W.J., Samali, A., van der Zee, A.G.J. and de Jong, S. Enhanced Anti-Tumor Efficacy of a Dr5-Specific Trail Variant Over Rhtrail in a Bioluminescent Ovarian Cancer Xenograft Model. Advances in Tnf Family Research. 691, 796-797.  

Fasehee, H., Westers, H., Bolhuis, A., Antelmann, H., Hecker, M., Quax, W.J., Mirlohi, A.F., van Dijl, J.M. and Ahmadian, G. Functional analysis of the sortase YhcS in Bacillus subtilis. Proteomics. 11, 3905-3913.  

Fibriansah, G., Puthan Veetil, V., Poelarends, G.J. and Thunnissen, A.-M.W.H. Structural Basis for the Catalytic Mechanism of Aspartate Ammonia Lyase. Biochemistry 50, 6053-6062.

Godinho, L.F., Reis, C.R., Rozeboom, H.J., Dekker, F.J., Dijkstra, B.W., Poelarends, G.J. and Quax, W.J. Enhancement of the enantioselectivity of carboxylesterase A by structure-based mutagenesis. J.Biotechnol. IN PRESS.

Godinho, L.F., Reis, C.R., Tepper, P.G., Poelarends, G.J. and Quax, W.J. Discovery of an Escherichia coli Esterase with High Activity and Enantioselectivity toward 1,2-O-Isopropylideneglycerol Esters. Appl.Environ.Microbiol. 77, 6094-6099.

Hendrawati, O., Woerdenbag, H.J., Michiels, P.J., Aantjes, H.G., van Dam, A. and Kayser, O. Identification of lignans and related compounds in Anthriscus sylvestris by LC-ESI-MS/MS and LC-SPE-NMR. Phytochemistry 72, 2172-2179.

Hendrawati, O., Woerdenbag, H.J., Hille, J., Quax, W.J. and Kayser, O. Seasonal Variations in the Deoxypodophyllotoxin Content and Yield of Anthriscus sylvestris L. (Hoffm.) Grown in the Field and under Controlled Conditions. J.Agric.Food Chem. 59, 8132-8139.

Hendrawati, O., Hille, J., Woerdenbag, H.J., Quax, W.J., Kayser, O. In vitro regeneration of wild chervil (Anthriscus sylvestris L.) In Vitro Cell Dev Biol Plant Epub 2011 Oct 25.

Limsuwan, S., Hesseling-Meinders, A., Voravuthikunchai, S.P., van Dijl, J.M. and Kayser, O. Potential antibiotic and anti-infective effects of rhodomyrtone from Rhodomyrtus tomentosa (Aiton) Hassk. on Streptococcus pyogenes as revealed by proteomics. Phytomedicine. 18, 934-940.

Nadal Jimenez, P., Koch, G., Thompson, J.A., Xavier, K.B., Cool, R.H. and Quax, W.J. The Multiple Signaling Systems Regulating Virulence in Pseudomonas aeruginosa. Microbiol Mol Biol Rev. IN PRESS.

Quax, W.J., Reis, C.R., van der Sloot, A.M., Tur, V., Szegezdi, E., Natoni, A., Cool, R.H., Samali, A. and Serrano, L. Designed Receptor Specific Rhtrail Variants Enhance Induction of Apoptosis in Cancer Cells. Advances in Tnf Family Research. 691, 726-727.

Raj, H., Puthan Veetil, V., Szymanski, W., Dekker, F.J., Quax, W.J., Feringa, B.L., Janssen, D.B. and Poelarends, G.J. Characterization of a thermostable methylaspartate ammonia lyase from Carboxydothermus hydrogenoformans. Appl.Microbiol.Biotechnol. , IN PRESS.

Reis, C.R., van Assen, A.H., Quax, W.J. and Cool, R.H. Unraveling the binding mechanism of trivalent tumor necrosis factor ligands and their receptors. Mol.Cell.Proteomics. 10, M110.002808.

Reis, C.R., van der Sloot, A.M., Szegezdi, E., Natoni, A., Tur, V., Cool, R.H., Samali, A., Serrano, L. and Quax, W.J. Enhancement of Antitumor Properties of Rhtrail by Affinity Increase Toward its Death Receptors. Advances in Tnf Family Research. 691, 807-808.

Szegezdi, E., Reis, C.R., van der Sloot, A.M., Natoni, A., O'Reilly, A., Reeve, J., Cool, R.H., O'Dwyer, M., Knapper, S., Serrano, L., Quax, W.J. and Samali, A. Targeting AML through DR4 with a novel variant of rhTRAIL. J.Cell.Mol.Med. 15, 2216-2231.

Szegezdi, E., van der Sloot, A.M., Alessandro, N., Mahalingam, D., Cool, R.H., Munoz, I.G., Montoya, G., Quax, W.J., Luis Serrano, S.d.J. and Samali, A. Improved Tumor Cell Killing by Trail Requires Selective and High Affinity Receptor Activation. Advances in Tnf Family Research. 691, 808-808.

van der Sloot, A.M., Szegezdi, E., Reis, C.R., Tur, V., Quax, W.J., Samali, A. and Serrano, L. Computational Design of Receptor Selective Trail Variants Rid B-5905-2008. Advances in Tnf Family Research. 691, 809-809.

Wahjudi, M., Papaioannou, E., Hendrawati, O., van Assen, A.H.G., van Merkerk, R., Cool, R.H., Poelarends, G.J. and Ouax, W.J. PA0305 of Pseudomonas aeruginosa is a quorum quenching acylhomoserine lactone acylase belonging to the Ntn hydrolase superfamily. Microbiology 157, 2042-2055.

Wu, B., Szymański, W., Wybenga, G.G., Heberling, M.M., Bartsch, S., de Wildeman, S., Poelarends, G.J., Feringa, B.L., Dijkstra, B.W., and Janssen, D.B. Mechanism-inspired engineering of phenylalanine aminomutase for enhanced β-regioselective asymmetric amination of cinnamates. Angew. Chem. Int. Ed., in press.

Zandvoort, E., Baas, B., Quax, W.J. and Poelarends, G.J. Systematic Screening for Catalytic Promiscuity in 4-Oxalocrotonate Tautomerase: Enamine Formation and Aldolase Activity. Chembiochem. 12, 602-609.

Zandvoort, E., Geertsema, E.M., Baas, B.J., Quax, W.J., and  Poelarends, G.J. Bridging between organocatalysis and biocatalysis: asymmetric addition of acetaldehyde to β-nitrostyrenes catalyzed by a promiscuous proline-based tautomerase. Angew. Chem. Int. Ed., in press.

Chapter in book:

Van der Sloot, A.M., Quax, W.J. Computational Design of TNF Ligand-Based Protein Therapeutics. In: Advances in TNF Family Research. Advances in Experimental Medicine and Biology, 2011, volume 691, Part 10, 521-534. DOI: 10.1007/978-1-4419-6612-4_54. Springer Science + Business Media.

Theses:

Nadal Jimenez, P. PvdQ acylases in fluorescent pseudmononads.

January 28, 2011. ISBN printed version: 978-90-367-4736-3.

Koch, G. The quorum-quenching acylase PvdQ: Biological role and directed evolution.

June 17, 2011. ISBN printed version: 978-90-367-4925-1.

Papaioannou, E. Silencing Pseudomonas Virulence.

September 9, 2011. ISBN printed version: 978-94-6182-007-5.

Hendrawati, O. Studies on Anthriscus sylvestris L. (Hoffm.) Metabolic engineering for combinatorial biosynthesis of podophyllotoxin.

October 28, 2011. ISBN printed version: 978-94-6182-027-3.

da Silva Godinho, L.F. Protein engineering of esterases: Climbing the protein fitness landscape.

November 18, 2011. ISBN printed version: 978-90-367-5131-5.

Patents:

CYTOKINE DESIGN

Vicente R Tur, Albert Martinus Van der Sloot, Margaret M Mullally, Robbert H Cool, Eva E Szegezdi, Afshin Samali, Gregorio Fernandez-Ballester, Luis Serrano, Wilhelmus J Quax.

International Publication Number and Date: US Patent 7,994,281; 2011/8/9