2013

Articles:

Baarsma HA, Bos S, Meurs H, Visser KH, Smit M, Schols AM, Langen RC, Kerstjens HA, Gosens R. Pharmacological inhibition of GSK-3 in a guinea pig model of LPS-induced pulmonary inflammation: I. Effects on lung remodeling and pathology. Respir Res 2013;14:113.

Baarsma HA, Engelbertink LH, van Hees LJ, Menzen MH, Meurs H, Timens W, Postma DS, Kerstjens HA, Gosens R. Glycogen synthase kinase-3 (GSK-3) regulates TGF-beta(1)-induced differentiation of pulmonary fibroblasts. Br J Pharmacol 2013;169:590-603.

Baarsma HA, Konigshoff M, Gosens R. The WNT signaling pathway from ligand secretion to gene transcription: molecular mechanisms and pharmacological targets. Pharmacol Ther 2013;138:66-83.

Dekkers BG, Racke K, Schmidt M. Distinct PKA and Epac compartmentalization in airway function and plasticity. Pharmacol Ther 2013;137:248-265.

Dekkers BG, Spanjer AI, van der Schuyt RD, Kuik WJ, Zaagsma J, Meurs H. Focal adhesion kinase regulates collagen I-induced airway smooth muscle phenotype switching. J Pharmacol Exp Ther. 2013 Jul;346(1):86-95.

Gechev TS, Benina M, Obata T, Tohge T, Sujeeth N, Minkov I, Hille J, Temanni MR, Marriott AS, Bergstrom E, Thomas-Oates J, Antonio C, Mueller-Roeber B, Schippers JH, Fernie AR, Toneva V. Molecular mechanisms of desiccation tolerance in the resurrection glacial relic Haberlea rhodopensis. Cell Mol Life Sci 2013;70:689-709.

Heijink IH, de Bruin HG, van den Berge M, Bennink LJ, Brandenburg SM, Gosens R, van Oosterhout AJ, Postma DS. Role of aberrant WNT signalling in the airway epithelial response to cigarette smoke in chronic obstructive pulmonary disease. Thorax 2013;68:709-716.

Karimian G, Buist-Homan M, Schmidt M, Tietge UJF, de Boer JF, Combettes L, Tordjmann T, Faber KN & Moshage H. Spingosine kinase inhibitor protects primary rat hepatocytes against bile acid-induced apoptosis. Biophys Biochem.Acta 2013;1832:1922-1929.

Keglowich L, Roth M, Philippova M, Resink T, Tjin G, Oliver B, Lardinois D, Dessus-Babus S, Gosens R, Hostettler Haack K, Tamm M, Borger P. Bronchial Smooth Muscle Cells of Asthmatics Promote Angiogenesis through Elevated Secretion of CXC-Chemokines (ENA-78, GRO-alpha, and IL-8). PLoS One 2013;8:e81494.

Kistemaker LE, Bos IS, Hylkema MN, Nawijn MC, Hiemstra PS, Wess J, Meurs H, Kerstjens HA, Gosens R. Muscarinic receptor subtype-specific effects on cigarette smoke-induced inflammation in mice. Eur Respir J 2013;42:1677-88.

Kumawat K, Menzen MH, Bos IS, Baarsma HA, Borger P, Roth M, Tamm M, Halayko AJ, Simoons M, Prins A, Postma DS, Schmidt M, Gosens R. Noncanonical WNT-5A signaling regulates TGF-beta-induced extracellular matrix production by airway smooth muscle cells. FASEB J 2012.

Meurs H, Oenema TA, Kistemaker LE, Gosens R. A new perspective on muscarinic receptor antagonism in obstructive airways diseases. Curr Opin Pharmacol 2013;13:316-323.

Meurs H, Dekkers BG, Maarsingh H, Halayko AJ, Zaagsma J, Gosens R. Muscarinic receptors on airway mesenchymal cells: Novel findings for an ancient target. Pulm Pharmacol Ther 2013;26:145-155.

Oenema TA, Maarsingh H, Smit M, Groothuis GM, Meurs H, Gosens R. Bronchoconstriction Induces TGF-beta Release and Airway Remodelling in Guinea Pig Lung Slices. PLoS One 2013;8:e65580.

Oenema TA, Mensink G, Smedinga L, Halayko AJ, Zaagsma J, Meurs H, Gosens R, Dekkers BG. Cross-talk between transforming growth factor-beta(1) and muscarinic M(2) receptors augments airway smooth muscle proliferation. Am J Respir Cell Mol Biol 2013;49:18-27.

Qureshi MK, Sujeeth N, Gechev TS and Hille J. The zinc finger protein ZAT11 modulates paraquat-induced programmed cell death in Arabidopsis thaliana. Acta Physiologiae Plantarum 2013;35:1863-1871.

Schmidt M , Dekker F & Maarsingh H. Exchange protein directly activated by cAMP (Epac): a multidomain cAMP mediator in the regulation of diverse biological functions. Pharmacol Rev 2013;65:670-709.

Verhees KJ, Pansters NA, Baarsma HA, Remels AH, Haegens A, de Theije CC, Schols AM, Gosens R, Langen RC. Pharmacological inhibition of GSK-3 in a guinea pig model of LPS-induced pulmonary inflammation: II. Effects on skeletal muscle atrophy. Respir Res 2013;14:117-9921-14-117.

West AR, Syyong HT, Siddiqui S, Pascoe CD, Murphy TM, Maarsingh H, Deng L, Maksym GN, Bosse Y. Airway contractility and remodeling: Links to asthma symptoms. Pulm Pharmacol Ther 2013;26:3-12.

Wright D, Sharma P, Ryu MH, Risse PA, Ngo M, Maarsingh H, Koziol-White C, Jha A, Halayko AJ, West AR. Models to study airway smooth muscle contraction in vivo, ex vivo and in vitro: Implications in understanding asthma. Pulm Pharmacol Ther 2013;26:24-36.

Wright DB, Trian T, Siddiqui S, Pascoe CD, Johnson JR, Dekkers BG, Dakshinamurti S, Bagchi R, Burgess JK, Kanabar V, Ojo OO. Phenotype modulation of airway smooth muscle in asthma. Pulm Pharmacol Ther 2013;26:42-49.

Wright DB, Trian T, Siddiqui S, Pascoe CD, Ojo OO, Johnson JR, Dekkers BG, Dakshinamurti S, Bagchi R, Burgess JK, Kanabar V. Functional phenotype of airway myocytes from asthmatic airways. Pulm Pharmacol Ther 2013;26:95-104.

Yamada M, Kawahara Y, Kaneko F, Kishikawa Y, Sotogaku N, Poppinga WJ, Folgering JH, Dremencov E, Kawahara H, Nishi A. Upregulation of the dorsal raphe nucleus-prefrontal cortex serotonin system by chronic treatment with escitalopram in hyposerotonergic Wistar-Kyoto rats. Neuropharmacology 2013;72:169-178.

Yeganeh B , Mukherjee S, Moir LM, Kumawat K, Kashani HH, Bagchi RA, Baarsma HA, Gosens R, Ghavami S. Novel non-canonical TGF-beta signaling networks: Emerging roles in airway smooth muscle phenotype and function. Pulm Pharmacol Ther 2013;26:50-63.

Dissertation:

Oenema T.A., Muscarinic receptors in airway smooth muscle, Roles in inflammation and remodeling. 2013, P1-203. Promotor: Meurs H., Copromotor: Gosens R.