2011

Articles:

Baarsma HA , Menzen MH, Halayko AJ, Meurs H, Kerstjens HA, Gosens R. beta-Catenin signaling is required for TGF-beta1-induced extracellular matrix production by airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 2011;301:L956-65.

Baarsma HA , Meurs H, Halayko AJ, Menzen MH, Schmidt M, Kerstjens HA, Gosens R. Glycogen synthase kinase-3 regulates cigarette smoke extract- and IL-1beta-induced cytokine secretion by airway smooth muscle. Am J Physiol Lung Cell Mol Physiol 2011;300:L910-9.  

Baarsma HA , Spanjer AI, Haitsma G, Engelbertink LH, Meurs H, Jonker MR, Timens W, Postma DS, Kerstjens HA, Gosens R. Activation of WNT/beta-catenin signaling in pulmonary fibroblasts by TGF-beta is increased in chronic obstructive pulmonary disease. PLoS One 2011;6:e25450.  

Dekkers BG , Bos IS, Zaagsma J, Meurs H. Functional consequences of human airway smooth muscle phenotype plasticity. Br J Pharmacol 2011.  

Ghizzoni M , Haisma HJ, Maarsingh H, Dekker FJ. Histone acetyltransferases are crucial regulators in NF-kappaB mediated inflammation. Drug Discov Today 2011;16:504-511.  

Gosens R , Stelmack GL, Bos ST, Dueck G, Mutawe MM, Schaafsma D, Unruh H, Gerthoffer WT, Zaagsma J, Meurs H, Halayko AJ. Caveolin-1 is required for contractile phenotype expression by airway smooth muscle cells. J Cell Mol Med 2011;15:2430-2442.  

Han X , Yu R, Ji L, Zhen D, Tao S, Li S, Sun Y, Huang L, Feng Z, Li X, Han G, Schmidt M, Han L. InlB-mediated Listeria monocytogenes internalization requires a balanced phospholipase D activity maintained through phospho-cofilin. Mol Microbiol 2011;81:860-880.  

Han X , Yu R, Zhen D, Tao S, Schmidt M, Han L. beta-1,3-Glucan-Induced Host Phospholipase D Activation Is Involved in Aspergillus fumigatus Internalization into Type II Human Pneumocyte A549 Cells. Plos One 2011;6:e21468.  

Konigshoff M , Uhl F, Gosens R. From molecule to man: integrating molecular biology with whole organ physiology in studying respiratory disease. Pulm Pharmacol Ther 2011;24:466-470.  

Lamyel F , Warnken-Uhlich M, Seemann WK, Mohr K, Kostenis E, Ahmedat AS, Smit M, Gosens R, Meurs H, Miller-Larsson A, Racke K. The beta2-subtype of adrenoceptors mediates inhibition of pro-fibrotic events in human lung fibroblasts. Naunyn Schmiedebergs Arch Pharmacol 2011;384:133-145.  

Maarsingh H , Dekkers BG, Zuidhof AB, Bos IS, Menzen MH, Klein T, Flik G, Zaagsma J, Meurs H. Increased arginase activity contributes to airway remodelling in chronic allergic asthma. Eur Respir J 2011;38:318-328.  

Michel MC , Cernecka H, Ochodnicky P. Desirable properties of beta3-adrenoceptor agonists: implications for the selection of drug development candidates. Eur J Pharmacol 2011;657:1-3.  

Pera T , Sami R, Zaagsma J, Meurs H. TAK1 plays a major role in growth factor-induced phenotypic modulation of airway smooth muscle. Am J Physiol Lung Cell Mol Physiol 2011;301:L822-8.

Pera T , Zuidhof A, Valadas J, Smit M, Schoemaker RG, Gosens R, Maarsingh H, Zaagsma J, Meurs H. Tiotropium inhibits pulmonary inflammation and remodelling in a guinea pig model of COPD. Eur Respir J 2011;38:789-796.

Roscioni SS , Dekkers BG, Prins AG, Menzen MH, Meurs H, Schmidt M, Maarsingh H. cAMP inhibits modulation of airway smooth muscle phenotype via the exchange protein activated by cAMP (Epac) and protein kinase A. Br J Pharmacol 2011;162:193-209.  

Roscioni SS , Prins AG, Elzinga CR, Menzen MH, Dekkers BG, Halayko AJ, Meurs H, Maarsingh H, Schmidt M. Protein kinase A and the exchange protein directly activated by cAMP (Epac) modulate phenotype plasticity in human airway smooth muscle. Br J Pharmacol 2011;164:958-969.  

Roscioni SS , Maarsingh H, Elzinga CRS, Schuur J, Menzen M, Halayko AJ, Meurs H, Schmidt M. Epac as a novel effector of airway smooth muscle relaxation RID H-2424-2011. J Cell Mol Med 2011;15:1551-1563.

Schmidt M , Michel MC. How can 1 + 1 = 3? beta2-adrenergic and glucocorticoid receptor agonist synergism in obstructive airway diseases. Mol Pharmacol 2011;80:955-958.  

Talaei F , Bouma H, Van der Graaf A, Strijkstra A, Schmidt M, Henning R. Serotonin and Dopamine Protect from Hypothermia/Rewarming Damage through the CBS/H(2)S Pathway. Plos One 2011;6:e22568.  

Talaei F , Hylkema MN, Bouma HR, Boerema AS, Strijkstra AM, Henning RH, Schmidt M. Reversible remodeling of lung tissue during hibernation in the Syrian hamster. J Exp Biol 2011;214:1276-1282.  

Van Beuge MM , Prakash J, Lacombe M, Gosens R, Post E, Reker-Smit C, Beljaars L, Poelstra K. Reduction of fibrogenesis by selective delivery of a Rho kinase inhibitor to hepatic stellate cells in mice. J Pharmacol Exp Ther 2011;337:628-635.  

Wisastra R , Ghizzoni M, Maarsingh H, Minnaard AJ, Haisma HJ, Dekker FJ. Isothiazolones; thiol-reactive inhibitors of cysteine protease cathepsin B and histone acetyltransferase PCAF. Org Biomol Chem 2011;9:1817-1822.  

Wisastra R , Poelstra K, Bischoff R, Maarsingh H, Haisma HJ, Dekker FJ. Antibody-free detection of protein tyrosine nitration in tissue sections. Chembiochem 2011;12:2016-2020.  

Wolf A , Gosens R, Meurs H, Haeberlein H. Pre-treatment with alpha-hederin increases beta-adrenoceptor mediated relaxation of airway smooth muscle. Phytomedicine 2011;18:214-218.  

National publications:

Bamberg JR. Listeria monocytogenes cell invasion: a new role for cofilin in co-ordinating actin dynamics and membrane lipids. Mol Microbiol 2011;81(4):851.

Dekkers BG. Rol extracellulaire matrixeiwitten in spieren van luchtwegen. Astma: gladde spiercellen bijsturen met RGDS. [Role of extracellular matrix proteins in the airways. Correcting airway smooth muscle cells in asthma]. Pharmaceutisch Weekblad 2011;146:30.  

Knight K. Hibernating hamsters reverse lung changes. Journal of Experimental Biology 2011;Inside JEB:i.

Dissertation:

Pera T . Inflammation and remodelling in experimental models of COPD: Mechanisms and therapeutic perspectives. June 17, 2011 2011:1-198.