Application of chemical biology techniques to study enzyme function in cell biology

Project description

The basic aim of our research is identify novel drug targets for treatment for immune diseases or cancer. We work with enzymes involved in epigenetic regulation of gene transcription called histone lysine deacetylases (HDAC) or with enzymes involved in DNA repair processes (macrophage migration inhibitor factor (MIF). We develop novel techniques to detect or inhibit enzyme activity in their cellular context. The disciplines cover organic chemistry, protein expression and purification, enzyme kinetics and cell-bases studies. The techniques to be used depend on the interest of the student as well as the availability of supervision capacity. Overall, our master students receive a versatile and profound training in wet-lab skills as well as a strong training in professional skills such as project management. 

Organization

The master research project will be conducted in the group of Prof. Frank J. Dekker.

Requirements

Bachelor in pharmacy, chemistry, biology or life science and technology.

Contact

For more information, please contact Prof. Frank J. Dekker.
Chemical and Pharmaceutical Biology, GRIP
Building 3211, room 326 at ADL1
Antonius Deusinglaan 1
9713 AV Groningen