Mini-symposium: Immune regulation and tissue protection in MS and stroke

When:	Mo 13-01-2025 15:00 - 17:00
Where:	UMCG - Anda van Kalkhoven Building, 3227.0133

This symposium is organized on the occasion of the thesis defence "Promises and challenges of selectively targeting TNF receptors in multiple sclerosis" by Valentina Pegoretti.

Mini symposium (UMCG, 3227.0133)	15.00 Introduction: Immune regulation and tissue protection in MS and stroke 15:05 Valentina Pegoretti (GELIFES): Promises and challenges of selectively targeting TNF receptors in multiple sclerosis 15:25 Natalia Orti Casañ (GELIFES): Investigating a novel TNF receptor 2 agonist as therapeutic strategy for multiple sclerosis 15:45 Coffee break 16:00 BCN lecture - Kate Lykke Lambertsen (University of Southern Denmark): Uncovering the sex-specific impact of immune responses on stroke outcome Abstract: Sex is an established risk factor for ischemic stroke, a leading course of death and permanent disability worldwide, but the sex-specific impact on neuroinflammation, tissue remodeling, and long-term outcome after ischemic stroke is not fully established yet. Microglia, the resident immune cells in the brain, have long been understood to be crucial to post-stroke neuroinflammation. They become promptly activated and exert both beneficial and harmful effects, depending on the specific stage of ischemic damage progression. Ealy after stroke, microglia exert beneficial functions by clearing debris and promoting oligodendrocyte precursor cell recruitment toward the ischemic lesion and preserving myelin integrity. However, the protective features of microglia are lost during disease progression, contributing to impaired functional recovery. This talk will focus on recent evidence describing sexual dimorphism in post-stroke immune responses in our well-established animal model of ischemic stroke, as well as in ischemic stroke patients. Special focus will be on sex-dependent post-stroke inflammatory responses and how different microglial phenotypes affect post-stroke regenerative responses and functional recovery in females versus males.

Mini symposium
(UMCG, 3227.0133)

15.00 Introduction: Immune regulation and tissue protection in MS and stroke

15:05 Valentina Pegoretti (GELIFES): Promises and challenges of selectively targeting TNF receptors in multiple sclerosis

15:25 Natalia Orti Casañ (GELIFES): Investigating a novel TNF receptor 2 agonist as therapeutic strategy for multiple sclerosis

15:45 Coffee break

16:00 BCN lecture - Kate Lykke Lambertsen (University of Southern Denmark): Uncovering the sex-specific impact of immune responses on stroke outcome

Abstract: Sex is an established risk factor for ischemic stroke, a leading course of death and permanent disability worldwide, but the sex-specific impact on neuroinflammation, tissue remodeling, and long-term outcome after ischemic stroke is not fully established yet. Microglia, the resident immune cells in the brain, have long been understood to be crucial to post-stroke neuroinflammation. They become promptly activated and exert both beneficial and harmful effects, depending on the specific stage of ischemic damage progression. Ealy after stroke, microglia exert beneficial functions by clearing debris and promoting oligodendrocyte precursor cell recruitment toward the ischemic lesion and preserving myelin integrity. However, the protective features of microglia are lost during disease progression, contributing to impaired functional recovery. This talk will focus on recent evidence describing sexual dimorphism in post-stroke immune responses in our well-established animal model of ischemic stroke, as well as in ischemic stroke patients. Special focus will be on sex-dependent post-stroke inflammatory responses and how different microglial phenotypes affect post-stroke regenerative responses and functional recovery in females versus males.

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