Changing the balance in apoptosis: key to enhance cisplatin sensitivity of testicular cancer

PhD ceremony: Mr. R. Koster, 13.15 uur, Academiegebouw, Broerstraat 5, Groningen

Thesis: Changing the balance in apoptosis: key to enhance cisplatin sensitivity of testicular cancer

Promotor(s): prof. J.A. Gietema, prof. R.P.H. Bischoff

Faculty: Medical Sciences

Testicular cancer is considered a paradigm of curable solid tumor and is therefore a very helpful “model” to investigate and understand the molecular determinants of chemotherapy sensitivity (and resistance) of solid tumors. Knowledge about mechanisms involved in the sensitivity and resistance of testicular cancer to DNA-damaging agents might contribute to the design of new treatment strategies to overcome cisplatin resistance of refractory testicular cancers and of other types of human cancers.