Hut, prof. dr. Roelof
Roelof Hut is professor Chronobiology aan de Faculty of Science and Engineering. In zijn onderzoek houdt hij zich met name bezig met chronobiologie. Dit is een onderdeel in de biologie dat zich richt op het bestuderen van het bioritme van het lichaam, zoals het innemen van voedingsstoffen, lichamelijke en geestelijke activiteit, slaapkwaliteit- en duur en gewichtsregulatie. Hut richt zich voornamelijk op de evolutionaire, ecologische en neurobiologische aspecten van deze bioritmen. In eerste instantie richtte hij zich voornamelijk op het bestuderen van zoogdieren, maar de laatste jaren heeft hij zijn werk uitgebreid met projecten bij vogels, insecten en mensen. Door zijn brede interesse in alle aspecten van chronobiologie vormt zijn werk een solide basis voor de breedte en diversiteit van het vakgebied.
Hut houdt zich onder andere bezig met de invloed van de zomer- en wintertijd op ons slaapritme. Ons dag- en nachtritme wordt bepaald door onze biologische klok, die weer beïnvloed wordt door de zonnetijd. De zon is onze belangrijkste lichtbron en bepaalt voor een groot deel wanneer we willen gaan slapen. Volgens Hut zorgt de zomertijd ervoor dat we twee uur van onze biologische klok zitten, waardoor we regelmatig de wekker zetten. Hij geeft aan dat het zetten van een wekker per definitie zorgt voor slaaptekort en pleit daarom samen met een aantal andere onderzoekers voor de afschaffing van de zomertijd.
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Contact en meer informatie
Publicaties
2024
McDowell,
R. J., Didikoglu, A., Woelders, T., Gatt, M. J., Moffatt, F.,
Notash, S., Hut, R. A., Brown, T. M., & Lucas, R.
J. (2024). Beyond Lux: methods for species and
photoreceptor-specific quantification of ambient light for
mammals. BMC Biology, 22(1),
Article 257. https://doi.org/10.1186/s12915-024-02038-1
van
Rosmalen, L., Deota, S., Maier, G., Le, H. D., Lin, T.,
Ramasamy, R. K., Hut, R. A., & Panda, S. (2024).
Energy balance drives diurnal and nocturnal brain
transcriptome rhythms. Cell reports,
43(3), Article 113951. https://doi.org/10.1016/j.celrep.2024.113951
Kong,
X., Meerlo, P., & Hut, R. A.
(2024). Melatonin does not affect the stress-induced phase
shifts of peripheral clocks in male mice.
Endocrinology (United States),
165(1), Article bqad183. https://doi.org/10.1210/endocr/bqad183
van
Rosmalen, L., Zhu, J., Maier, G., Gacasan, E. G., Lin,
T., Zhemchuzhnikova, E., Rothenberg, V., Razu, S.,
Deota, S., Ramasamy, R. K., Sah, R. L., McCulloch, A. D.,
Hut, R. A., & Panda, S. (2024). Multi-organ
transcriptome atlas of a mouse model of relative energy deficiency
in sport. Cell Metabolism,
36(9), 2015-2037. https://doi.org/10.1016/j.cmet.2024.08.001
Lucas,
R. J., Allen, A. E., Brainard, G. C., Brown, T. M., Dauchy, R. T.,
Didikoglu, A., Do, M. T. H., Gaskill, B. N., Hattar, S., Hawkins,
P., Hut, R. A., McDowell, R. J., Nelson, R. J., Prins,
J. B., Schmidt, T. M., Takahashi, J. S., Verma, V., Voikar, V.,
Wells, S., & Peirson, S. N. (2024). Recommendations for
measuring and standardizing light for laboratory mammals to improve
welfare and reproducibility in animal research.
PLOS BIOLOGY, 22(3 March), Article
e3002534. https://doi.org/10.1371/journal.pbio.3002535
van
Doorn, G. S., Schepers, J., Hut, R. A., &
Groot, A. T. (2024). Sex-specific expression of circadian
rhythms enables allochronic speciation. Evolution
Letters, Article qrae049. Advance online publication.
https://doi.org/10.1093/evlett/qrae049
2023
Wang,
Y., Jin, L., Belušič, G., Beukeboom, L.
W., Wertheim, B., & Hut, R. A.
(2024). Circadian entrainment to red-light Zeitgebers
and action spectrum for entrainment in the jewel wasp Nasonia
vitripennis. Journal of Comparative Physiology
A: Neuroethology, Sensory, Neural, and Behavioral
Physiology, 210, 459–472. https://doi.org/10.1007/s00359-023-01672-4
Floessner,
T. S. E., Benetta, E. D., Beersma, D. G. M., &
Hut, R. A. (2024). Variation in photoperiod response
corresponds to differences in circadian light sensitivity in
northern and southern Nasonia vitripennis lines.
Journal of Comparative Physiology A: Neuroethology,
Sensory, Neural, and Behavioral Physiology,
210, 667-676. https://doi.org/10.1007/s00359-023-01674-2
Kong,
X., Luxwolda, M., Hut, R.
A., & Meerlo, P. (2023).
Adrenalectomy prevents the effects of social defeat stress on
PER2 rhythms in some peripheral tissues in male mice.
Hormones and Behavior, 150, Article
105326. https://doi.org/10.1016/j.yhbeh.2023.105326
van
Dalum, M. J., van Rosmalen, L., Appenroth, D., Cazarez
Marquez, F., Roodenrijs, R. T. M., de Wit, L.,
Hut, R. A., & Hazlerigg, D. G. (2023). Ambient
temperature effects on the spring and autumn somatic growth
trajectory show plasticity in the photoneuroendocrine response
pathway in the tundra vole. Journal of Biological
Rhythms, 38(6), 586–600. https://doi.org/10.1177/07487304231190156
Wang,
Y., Belušič, G., Pen, I.,
Beukeboom, L. W., Wertheim, B., Stavenga,
D. G., & Hut, R. A. (2023). Circadian
rhythm entrainment of the jewel wasp, Nasonia vitripennis,
by antagonistic interactions of multiple spectral inputs.
Proceedings of the Royal Society B,
290(1992), Article 20222319. https://doi.org/10.1098/rspb.2022.2319
Giménez,
M. C., Luxwolda, M., Van Stipriaan, E. G.,
Bollen, P. P., Hoekman, R. L., Koopmans, M.
A., Arany, P. R., Krames, M. R., Berends, A. C., Hut,
R. A., & Gordijn, M. C. M. (2023).
Effects of near-infrared light on well-being and health in
human subjects with mild sleep-related complaints: A double-blind,
randomized, placebo-controlled study.
Biology, 12(1), Article 60. https://doi.org/10.3390/biology12010060
Woelders,
T., Revell, V. L., Middleton, B., Ackermann, K., Kayser, M.,
Raynaud, F. I., Skene, D. J., & Hut, R. A. (2023).
Machine learning estimation of human body time using
metabolomic profiling. Proceedings of the National
Academy of Sciences of the United States of America,
120(18), Article e2212685120. https://doi.org/10.1073/pnas.2212685120
van
Rosmalen, L., Schepers, R., Hao, W., Przybylska-Piech, A.
S., Herman, J. S., Stojak, J., Wójcik, J. M., van de
Zande, L., Searle, J. B., & Hut, R. A.
(2023). Seasonal adaptation: Geographic
photoperiod-temperature patterns explain genetic variation in the
common vole Tsh receptor.
Genes, 14(2), Article 292. https://doi.org/10.3390/genes14020292
de
Wit, L., Hamberg, M. R., Ross, A. M.,
Goris, M., Lie, F. F., Ruf, T., Giroud,
S., Henning, R. H., & Hut, R. A.
(2023). Temperature effects on DNA damage during
hibernation. Physiological and Biochemical
Zoology, 96(2), 144-152. https://doi.org/10.1086/722904
Wang,
Y., Beukeboom, L. W., Wertheim,
B., & Hut, R. A. (2023).
Transcriptomic analysis of light-induced genes in Nasonia
vitripennis: Possible implications for circadian light
entrainment pathways. Biology,
12(9), Article 1215. https://doi.org/10.3390/biology12091215
2022
Lok,
R., Woelders, T., van Koningsveld, M. J., Oberman, K.,
Fuhler, S. G., Beersma, D. G. M., & Hut, R. A.
(2022). Bright light decreases peripheral skin temperature in
healthy men: A forced desynchrony study under dim and bright light
(II). Journal of Biological Rhythms,
37(4), 417-428. https://doi.org/10.1177/07487304221096948
Lok,
R., Woelders, T., Gordijn, M. C. M., van Koningsveld,
M. J., Oberman, K., Fuhler, S. G., Beersma, D. G.
M., & Hut, R. A. (2022). Bright light during
wakefulness improves sleep quality in healthy men: A forced
desynchrony study under dim and bright light (III).
Journal of Biological Rhythms,
37(4), 429-441. https://doi.org/10.1177/07487304221096910
Lok,
R., Woelders, T., van Koningsveld, M. J., Oberman, K.,
Fuhler, S. G., Beersma, D. G. M., & Hut, R. A.
(2022). Bright light increases alertness and not cortisol in
healthy men: A forced desynchrony study under dim and bright light
(I). Journal of Biological Rhythms,
37(4), 403–416. https://doi.org/10.1177/07487304221096945
Kong,
X., Ota, S. M., Suchecki, D., Lan, A., Peereboom, A.
I., Hut, R. A., & Meerlo, P. (2022).
Chronic social defeat stress shifts peripheral circadian
clocks in male mice in a tissue-specific and time-of-day dependent
fashion. Journal of Biological
Rhythms, 37(2), 164-176. https://doi.org/10.1177/07487304211065336
van
Rosmalen, L., Riedstra, B., Beemster, N.,
Dijkstra, C., & Hut, R. A. (2022).
Differential temperature effects on photoperiodism in female
voles: A possible explanation for declines in vole
populations. Molecular Ecology,
31(12), 3360-3373. https://doi.org/10.1111/mec.16467
van
Rosmalen, L., Riede, S. J., Pilorz, V., Adage,
T., Scheurink, A. J. W., van der Vinne, V.,
& Hut, R. A. (2022). Nocturnal and diurnal
behavior assessed by the “work-for-food” protocol in
small rodents. In T. Hirota, M. Hatori, & S. Panda
(Eds.), Circadian Clocks (pp. 187-216). (Neuromethods;
Vol. 186). Humana Press. https://doi.org/10.1007/978-1-0716-2577-4_9
van
Dis, N. E., Risse, J. E., Pijl, A. S., Hut, R.
A., Visser, M. E., & Wertheim,
B. (2022). Transcriptional regulation underlying the
temperature response of embryonic development rate in the winter
moth. Molecular Ecology,
31(22), 5795-5812. https://doi.org/10.1111/mec.16705
2021
van
Hasselt, S. J., Hut, R. A., Allocca, G.,
Vyssotski, A. L., Piersma, T., Rattenborg, N.
C., & Meerlo, P. (2021). Cloud cover
amplifies the sleep-suppressing effect of artificial light at night
in geese. Environmental Pollution,
273, Article 116444. https://doi.org/10.1016/j.envpol.2021.116444
van
Rosmalen, L., & Hut, R. A. (2021).
Food and temperature change photoperiodic responses in two
vole species. The Journal of Experimental
Biology, 224(23). https://doi.org/10.1242/jeb.243030
van
Rosmalen, L., van Dalum, J., Appenroth, D., Roodenrijs, R.
T. M., de Wit, L., Hazlerigg, D. G., & Hut,
R. A. (2021). Mechanisms of temperature modulation in
mammalian seasonal timing. The FASEB
Journal, 35(5), Article e21605. https://doi.org/10.1096/fj.202100162R
van
Rosmalen, L., & Hut, R. A. (2021).
Negative energy balance enhances ultradian rhythmicity in
spring-programmed voles. Journal of Biological
Rhythms, 36(4), 359-368. https://doi.org/10.1177/07487304211005640
Homberg,
J. R., Adan, R. A. H., Alenina, N., Asiminas, A., Bader, M.,
Beckers, T., Begg, D. P., Blokland, A., Burger, M. E., van
Dijk, G., Eisel, U. L. M., Elgersma, Y.,
Englitz, B., Fernandez-Ruiz, A., Fitzsimons, C. P., van Dam, A.-M.,
Gass, P., Grandjean, J., Havekes, R., ... Genzel, L.
(2021). The continued need for animals to advance brain
research. Neuron, 109(15),
2374-2379. https://doi.org/10.1016/j.neuron.2021.07.015
Ota,
S. M., Kong, X., Hut, R., Suchecki,
D., & Meerlo, P. (2021). The impact of
stress and stress hormones on endogenous clocks and circadian
rhythms. Frontiers in
Neuroendocrinology, 63, Article 100931. https://doi.org/10.1016/j.yfrne.2021.100931
van
Dis, N. E., van der Zee, M., Hut, R. A.,
Wertheim, B., & Visser, M. E. (2021).
Timing of increased temperature sensitivity coincides with
nervous system development in winter moth embryos.
The Journal of Experimental Biology,
224(17), Article jeb242554. https://doi.org/10.1242/jeb.242554
2020
Lok,
R., Zerbini, G., Gordijn, M. C. M., Beersma, D. G.
M., & Hut, R. A. (2020). Gold, silver or
bronze: Circadian variation strongly affects performance in Olympic
athletes. Scientific Reports,
10(1), Article 16088. https://doi.org/10.1038/s41598-020-72573-8
van
Rosmalen, L., van Dalum, J., Hazlerigg, D. G., &
Hut, R. A. (2020). Gonads or body? Differences in
gonadal and somatic photoperiodic growth response in two vole
species. The Journal of Experimental
Biology, 223. https://doi.org/10.1242/jeb.230987
Ota,
S. M., Hut, R. A., Riede, S. J., Crosby,
P., Suchecki, D., & Meerlo, P. (2020).
Social stress and glucocorticoids alter PERIOD2 rhythmicity
in the liver, but not in the suprachiasmatic nucleus.
Hormones and Behavior, 120, Article
104683. https://doi.org/10.1016/j.yhbeh.2020.104683
2019
Lok,
R., van Koningsveld, M. J., Gordijn, M. C. M.,
Beersma, D. G. M., & Hut, R. A. (2019).
Daytime melatonin and light independently affect human
alertness and body temperature. Journal of Pineal
Research, 67(1), Article e12583. https://doi.org/10.1111/jpi.12583
Wang,
D., Li, N., Tian, L., Ren, F., Li, Z., Chen, Y., Liu, L., Hu, X.,
Zhang, X., Song, Y., Hut, R. A., & Liu, X.-H.
(2019). Dynamic expressions of hypothalamic genes regulate
seasonal breeding in a natural rodent population.
Molecular Ecology, 28(15),
3508-3522. https://doi.org/10.1111/mec.15161
Floessner,
T. S. E., Boekelman, F. E., Druiven, S. J. M.,
de Jong, M., Rigter, P. M. F., Beersma, D. G. M., & Hut,
R. A. (2019). Lifespan is unaffected by size and
direction of daily phase shifts in Nasonia, a hymenopteran insect
with strong circadian light resetting. Journal of
Insect Physiology, 117, Article 103896. https://doi.org/10.1016/j.jinsphys.2019.103896
Salis,
L., Caro, S. P., Hut, R. A., Vernooij, L., &
Visser, M. E. (2019). Manipulation of photoperiod
perception advances gonadal growth but not laying date in the great
tit. Journal of Avian Biology,
50(10), Article 02197. https://doi.org/10.1111/jav.02197
van
der Vinne, V., Tachinardi, P., Riede, S. J., Akkerman,
J., Scheepe, J., Daan, S., & Hut, R. A. (2019).
Maximising survival by shifting the daily timing of
activity. Ecology Letters,
22(12), 2097-2102. https://doi.org/10.1111/ele.13404
van
Dis, N. E., van der Zee, M., Hut, R. A.,
Wertheim, B., & Visser, M. (2019).
Winter moth adaptation to climate change: Genetic changes
in thermal plasticity of embryonic development rate.
Poster session presented at ESEB 2019, Turku, Finland.
van
Dis, N. E., van der Zee, M., Hut, R. A.,
Wertheim, B., & Visser, M. (2019).
Winter moth (Operophtera brumata) adaptation to
climate change: Embryonic response to temperature.
Poster session presented at Netherlands Society for Evolutionary
Biology Meeting 2019, Ede, Netherlands.
2018
Woelders,
T., Leenheers, T., Gordijn, M. C. M., Hut, R.
A., Beersma, D. G. M., & Wams, E. J. (2018).
Correction for Woelders et al., Melanopsin- and
L-cone–induced pupil constriction is inhibited by S- and
M-cones in humans. Proceedings of the National
Academy of Science of the United States of America,
115(9), Article E2147. https://doi.org/10.1073/pnas.1801001115
Woelders,
T., Wams, E. J., Gordijn, M. C. M., Beersma, D. G.
M., & Hut, R. A. (2018). Integration of
color and intensity increases time signal stability for the human
circadian system when sunlight is obscured by clouds.
Scientific Reports, 8(1), Article
15214. https://doi.org/10.1038/s41598-018-33606-5
Woelders,
T., Leenheers, T., Gordijn, M. C. M., Hut, R.
A., Beersma, D. G. M., & Wams, E. J. (2018).
Melanopsin- and L-cone-induced pupil constriction is
inhibited by S- and M-cones in humans. Proceedings
of the National Academy of Science of the United States of
America, 115(4), 792-797. https://doi.org/10.1073/pnas.1716281115
Trillmich,
F., von Engelhardt, N., & Hut, R. A. (2018).
Obituary: Professor Serge Daan (11 June 1940-9 February
2018). Ethology, 124(5),
279-280. https://doi.org/10.1111/eth.12742
Hut,
R. A., Gerkema, M. P., Beersma, D. G. M.,
& Tinbergen, J. M. (2018). Serge Daan In
Memoriam. Journal of Biological
Rhythms, 33(2), 111-116. https://doi.org/10.1177/0748730418768594
Lok,
R., Woelders, T., Gordijn, M. C. M., Hut, R.
A., & Beersma, D. G. M. (2018). White light during
daytime does not improve alertness in well-rested
individuals. Journal of Biological
Rhythms, 33(6), 637-648. https://doi.org/10.1177/0748730418796036
2017
Lech,
K., Liu, F., Davies, S. K., Ackermann, K., Ang, J. E., Middleton,
B., Revell, V. L., Raynaud, F. I., Hoveijn, I., Hut, R.
A., Skene, D. J., & Kayser, M. (2018). Erratum to:
investigation of metabolites for estimating blood deposition
time. International journal of legal
medicine, 132(1), 33. https://doi.org/10.1007/s00414-017-1670-y
Lech,
K., Liu, F., Davies, S. K., Ackermann, K., Ang, J. E., Middleton,
B., Revell, V. L., Raynaud, F. J., Hoveijn, I., Hut, R.
A., Skene, D. J., & Kayser, M. (2018).
Investigation of metabolites for estimating blood deposition
time. International journal of legal
medicine, 132, 25-32. https://doi.org/10.1007/s00414-017-1638-y
Salis,
L., van den Hoorn, E., Beersma, D. G. M., Hut, R.
A., & Visser, M. E. (2018).
Photoperiodic cues regulate phenological carry-over effects
in an herbivorous insect. Functional
Ecology, 32(1), 171-180. https://doi.org/10.1111/1365-2435.12953
Hut,
R., & Floessner, T. (2017). Basic
principles underlying biological oscillations and their
entrainment. In V. Kumar (Ed.), Biological Timekeeping:
Clocks, Rhythms and Behaviour (pp. 47-58). Springer India. https://doi.org/10.1007/978-81-322-3688-7_3
Woelders,
T., Beersma, D. G. M., Gordijn, M. C. M., Hut,
R. A., & Wams, E. J. (2017). Daily light exposure
patterns reveal phase and period of the human circadian
clock. Journal of Biological Rhythms,
32(3), 274-286. https://doi.org/10.1177/0748730417696787
van
der Veen, D. R., Riede, S. J., Heideman, P. D., Hau,
M., van der Vinne, V., & Hut, R. A. (2017).
Flexible clock systems: Adjusting the temporal
programme. Philosophical Transactions of the Royal
Society of London. Series B: Biological Sciences,
372(1734), Article 20160254. https://doi.org/10.1098/rstb.2016.0254
Wams,
E. J., Woelders, T., Marring, I., van Rosmalen, L.,
Beersma, D. G. M., Gordijn, M. C. M., & Hut,
R. A. (2017). Linking light exposure and subsequent
sleep: A field polysomnography study in humans.
Sleep, 40(12), Article zsx165. https://doi.org/10.1093/sleep/zsx165
Wams,
E. J., Riede, S. J., van der Laan, I., ten Bulte,
T., & Hut, R. A. (2017). Mechanisms of
non-photic entrainment. In V. Kumar (Ed.), Biological
Timekeeping: Clocks, Rhythms and Behaviour (pp. 395-404).
Springer India. https://doi.org/10.1007/978-81-322-3688-7_18
Riede,
S. J., van der Vinne, V., & Hut, R. A.
(2017). The flexible clock: Predictive and reactive
homeostasis, energy balance and the circadian regulation of
sleep-wake timing. Journal of Experimental
Biology, 220(5), 738-749. https://doi.org/10.1242/jeb.130757
Hau,
M., Dominoni, D., Casagrande, S., Buck, C. L., Wagner, G.,
Hazlerigg, D., Greives, T., & Hut, R. A. (2017).
Timing as a sexually selected trait: The right mate at the
right moment. Philosophical Transactions of the
Royal Society of London. Series B: Biological Sciences,
372(1734), Article 20160249. https://doi.org/10.1098/rstb.2016.0249
2015
van
der Vinne, V., Gorter, J. A., Riede, S.
J., & Hut, R. A. (2015). Diurnality
as an energy-saving strategy: Energetic consequences of temporal
niche switching in small mammals. Journal of
Experimental Biology, 218(16), 2585-93. https://doi.org/10.1242/jeb.119354
van
der Vinne, V., Akkerman, J., Lanting, G. D., Riede, S.
J., & Hut, R. A. (2015). Food reward
without a timing component does not alter the timing of activity
under positive energy balance.
Neuroscience, 304, 260-265. https://doi.org/10.1016/j.neuroscience.2015.07.061
van
der Vinne, V., Zerbini, G., Siersema, A., Pieper, A., Merrow,
M., Hut, R. A., Roenneberg, T., & Kantermann, T.
(2015). Timing of examinations affects school performance
differently in early and late chronotypes. Journal
of Biological Rhythms, 30(1), 53-60. https://doi.org/10.1177/0748730414564786
2014
van
der Vinne, V., Riede, S. J., Gorter, J.
A., Eijer, W. G., Sellix, M. T., Menaker, M., Daan, S.,
Pilorz, V., & Hut, R. A. (2014). Cold and
hunger induce diurnality in a nocturnal mammal.
Proceedings of the National Academy of Sciences of the
United States of America, 111(42), 15256-60.
https://doi.org/10.1073/pnas.1413135111
Ensing,
E. P., Ciuti, S., de Wijs, F. A. L. M., Lentferink, D.
H., Ten Hoedt, A., Boyce, M. S., & Hut, R.
A. (2014). GPS based daily activity patterns in
European red deer and North American elk (Cervus elaphus):
Indication for a weak circadian clock in ungulates.
PLoS ONE, 9(9), Article 106997. https://doi.org/10.1371/journal.pone.0106997
Hut,
R. A., Dardente, H., & Riede, S. J. (2014).
Seasonal timing: How does a hibernator know when to stop
hibernating? Current Biology,
24(13), R602-R605. https://doi.org/10.1016/j.cub.2014.05.061
2013
Helm,
B., Ben-Shlomo, R., Sheriff, M. J., Hut, R. A.,
Foster, R., Barnes, B. M., & Dominoni, D. (2013). Annual
rhythms that underlie phenology: Biological time-keeping meets
environmental change. Proceedings of the Royal
Society B, 280(1765), Article 20130016. https://doi.org/10.1098/rspb.2013.0016
Hut,
R. A., Paolucci, S., Dor, R., Kyriacou, C. P., & Daan,
S. (2013). Latitudinal clines: An evolutionary view on
biological rhythms. Proceedings of the Royal
Society B, 280(1765), Article 20130433. https://doi.org/10.1098/rspb.2013.0433
Caro,
S. P., Schaper, S. V., Hut, R. A., Ball, G. F.,
& Visser, M. E. (2013). The case of the missing
mechanism: How does temperature influence seasonal timing in
endotherms? PLOS BIOLOGY,
11(4), Article e1001517. https://doi.org/10.1371/journal.pbio.1001517
Gerkema,
M. P., Davies, W. I. L., Foster, R. G., Menaker, M.,
& Hut, R. A. (2013). The nocturnal bottleneck and
the evolution of activity patterns in mammals.
Proceedings of the Royal Society B,
280(1765), Article 20130508. https://doi.org/10.1098/rspb.2013.0508
Mulder,
C., van der Zee, E. A., Hut, R. A.,
& Gerkema, M. P. (2013). Time-place learning and
memory persist in mice lacking functional Per1 and
Per2 clock genes. Journal of Biological
Rhythms, 28(6), 367-379. https://doi.org/10.1177/0748730413512958
2012
Hut,
R. A., Kronfeld-Schor, N., van der Vinne, V., & De la
Iglesia, H. (2012). In search of a temporal niche:
Environmental factors. In The Neurobiology of Circadian
Timing (Vol. 199, pp. 281-304). (Progress in Brain Research;
Vol. 199). Elsevier. https://doi.org/10.1016/B978-0-444-59427-3.00017-4
Strijkstra,
A. M., Koopmans, T., Bouma, H. R., Boer, S. F.
D., Hut, R. A., & Boerema, A.
S. (2012). On the Dissimilarity of 5′-AMP
Induced Hypothermia and Torpor in Mice. In W. Arnold, C.
Bieber, E. Millesi, & T. Ruf (Eds.), Living in a Seasonal
World: Thermoregulatory and Metabolic Adaptations (pp.
351-362). Springer Verlag. https://doi.org/10.1007/978-3-642-28678-0_31
Krol,
E., Douglas, A., Dardente, H., Birnie, M. J., van der Vinne, V.,
Eijer, W. G., Gerkema, M. P., Hazlerigg, D. G.,
Hut, R. A., & Król, E. (2012). Strong
pituitary and hypothalamic responses to photoperiod but not to
6-methoxy-2-benzoxazolinone in female common voles (Microtus
arvalis). General and Comparative
Endocrinology, 179(2), 289-295. https://doi.org/10.1016/j.ygcen.2012.09.004
2011
Hut,
R. A., & Beersma, D. G. M. (2011). Evolution of
time-keeping mechanisms: early emergence and adaptation to
photoperiod. Philosophical Transactions of the
Royal Society of London. Series B: Biological Sciences,
366(1574), 2141-2154. https://doi.org/10.1098/rstb.2010.0409
Hut,
R. A. (2011). Photoperiodism: Shall EYA Compare Thee
to a Summer's Day? Current Biology,
21(1), R22-R25. https://doi.org/10.1016/j.cub.2010.11.060
Hut,
R. A., & van der Zee, E. A. (2011).
The cholinergic system, circadian rhythmicity, and time
memory. Behavioral Brain Research,
221(2), 466-480. https://doi.org/10.1016/j.bbr.2010.11.039
Hut,
R. A., Pilorz, V., Boerema, A. S., Strijkstra,
A. M., & Daan, S. (2011). Working for Food Shifts
Nocturnal Mouse Activity into the Day. PLoS
ONE, 6(3), Article 17527. https://doi.org/10.1371/journal.pone.0017527
2010
Bouma,
H. R., Strijkstra, A. M., Boerema, A. S.,
Deelman, L. E., Epema, A. H., Hut, R. A.,
Kroese, F. G. M., & Henning, R. H. (2010).
Blood cell dynamics during hibernation in the European Ground
Squirrel. Veterinary Immunology and
Immunopathology, 136(3-4), 319-323. https://doi.org/10.1016/j.vetimm.2010.03.016
Roenneberg,
T., Hut, R., Daan, S., & Merrow, M. (2010).
Entrainment Concepts Revisited. Journal of
Biological Rhythms, 25(5), 329-339. https://doi.org/10.1177/0748730410379082
2009
Daan,
S., Comas, M., Spoelstra, K., Hut, R., & Beersma,
D. (2009). Circadian entrainment by different daylengths: The
roles of dawn and dusk. Sleep Science,
2(4), 7.
Sosniyenko,
S., Hut, R. A., Daan, S., & Sumova, A. (2009).
Influence of photoperiod duration and light-dark transitions
on entrainment of Per1 and Per2 gene and protein expression in
subdivisions of the mouse suprachiasmatic nucleus.
European Journal of Neuroscience,
30(9), 1802-1814. https://doi.org/10.1111/j.1460-9568.2009.06945.x
van
der Zee, E. A., Boersma, G. J., &
Hut, R. A. (2009). The neurobiology of circadian
rhythms. Current Opinion in Pulmonary
Medicine, 15(6), 534-539. https://doi.org/10.1097/MCP.0b013e3283319b29
Beersma,
D. G. M., Comas, M., Hut, R. A., Gordijn, M. C.
M., Rueger, M., & Daan, S. (2009). The progression
of circadian phase during light exposure in animals and
humans. Journal of Biological Rhythms,
24(2), 153-160. https://doi.org/10.1177/0748730408330196
Comas,
M., & Hut, R. A. (2009). Twilight and
Photoperiod Affect Behavioral Entrainment in the House Mouse (Mus
musculus). Journal of Biological
Rhythms, 24(5), 403-412. https://doi.org/10.1177/0748730409343873
2008
Comas,
M., Beersma, D. G. M., Hut, R. A., & Daan, S.
(2008). Circadian phase resetting in response to light-dark
and dark-light transitions. Journal of Biological
Rhythms, 23(5), 425-434. https://doi.org/10.1177/0748730408321567
van
der Zee, E. A., Havekes, R., Barf, R. P.,
Hut, R. A., Nijholt, I. M., Jacobs, E.
H., & Gerkema, M. P. (2008). Circadian
time-place learning in mice depends on Cry genes.
Current Biology, 18(11), 844-848. https://doi.org/10.1016/j.cub.2008.04.077
Cameron,
M. A., Barnard, A. R., Hut, R. A., Bonnefont, X., van
der Horst, G. T. J., Hankins, M. W., & Lucas, R. J. (2008).
Electroretinography of Wild-Type and Cry Mutant Mice Reveals
Circadian Tuning of Photopic and Mesopic Retinal Responses.
Journal of Biological Rhythms,
23(6), 489-501. https://doi.org/10.1177/0748730408325874
Beersma,
D. G. M., van Bunnik, B. A. D., Hut, R. A., &
Daan, S. (2008). Emergence of circadian and photoperiodic
system level properties from interactions among pacemaker
cells. Journal of Biological Rhythms,
23(4), 362-373. https://doi.org/10.1177/0748730408317992
Oklejewicz,
M., Destici, E., Tamanini, F., Hut, R. A., Janssens,
R., & van der Horst, G. T. J. (2008). Phase resetting of
the mammalian circadian clock by DNA damage.
Current Biology, 18(4), 286-291. https://doi.org/10.1016/j.cub.2008.01.047
Hut,
R. A., Oklejewicz, M., Rieux, C., & Cooper, H. M.
(2008). Photic sensitivity ranges of hamster pupillary and
circadian phase responses do not overlap. Journal
of Biological Rhythms, 23(1), 37-48. https://doi.org/10.1177/0748730407311851
Veen,
D. R. V. D., Mulder, E. G. A., Oster, H.,
Gerkema, M. P., & Hut, R. A. (2008).
SCN-AVP release of mPer1/mPer2 double-mutant mice in
vitro. Journal of Circadian Rhythms,
6(1). https://doi.org/10.1186/1740-3391-6-5
2007
Rüdiger,
J., van der Zee, E. A., Strijkstra, A. M.,
Aschoff, A., Daan, S., & Hut, R. A. (2007).
Dynamics in the ultrastructure of asymmetric axospinous
synapses in the frontal cortex of hibernating European ground
squirrels (Spermophilus citellus).
Synapse, 61(5), 343-352. https://doi.org/10.1002/syn.20380
Drouyer,
E., Rieux, C., Hut, R. A., & Cooper, H. M. (2007).
Responses of suprachiasmatic nucleus neurons to light and
dark adaptation: Relative contributions of melanopsin and rod-cone
inputs. The Journal of Neuroscience,
27(36), 9623-9631. https://doi.org/10.1523/JNEUROSCI.1391-07.2007
Long,
R. A., Hut, R. A., & Barnes, B. M. (2007).
Simultaneous collection of body temperature and activity data
in burrowing mammals: a new technique. Journal of
wildlife management, 71(4), 1375-1379. https://doi.org/10.2193/2006-399
2006
Lincoln,
G. A., Clarke, I. J., Hut, R. A., & Hazlerigg, D.
G. (2006). Characterizing a mammalian circannual
pacemaker. Science,
314(5807), 1941-1944. https://doi.org/10.1126/science.1132009
Dkhissi-Benyahya,
O., Rieux, C., Hut, R. A., & Cooper, H. M. (2006).
Immunohistochemical evidence of a melanopsin cone in human
retina. Investigative ophthalmology & visual
science, 47(4), 1636-1641. https://doi.org/10.1167/iovs.05-1459
Oster,
H., Damerow, S., Hut, R. A., & Eichele, G. (2006).
Transcriptional Profiling in the Adrenal Gland Reveals
Circadian Regulation of Hormone Biosynthesis Genes and Nucleosome
Assembly Genes. Journal of Biological
Rhythms, 21(5), 350-361. https://doi.org/10.1177/0748730406293053
2004
Sandovici,
M., Henning, RH., Hut, RA.,
Strijkstra, AM., Epema, AH., van Goor, H., &
Deelman, LE. (2004). Differential regulation of
glomerular and interstitial endothelial nitric oxide synthase
expression in the kidney of hibernating ground squirrel.
Nitric oxide-Biology and chemistry,
11(2), 194-200. https://doi.org/10.1016/j.niox.2004.08.002
Cooper,
HM., Chiquet, C., Rieux, C., Hut, RA., Gronfier, C.,
Claustrat, B., Brun, J., & Denis, P. (2004).
Mid-wavelength monochromatic light is more effective for
suppressing plasma melatonin in humans than broadband white
light. Investigative ophthalmology & visual
science, 45, U426-U426.
Chiquet,
C., Gronfier, C., Rieux, C., Hut, RA., Claustrat, B.,
Brun, J., Denis, P., & Cooper, HM. (2004). Reduced
sensitivity to light suppression of nocturnal plasma melatonin in
glaucoma patients. Investigative ophthalmology
& visual science, 45, U425-U425.
Everts,
LG., Strijkstra, AM., Hut, RA., Hoffmann, IE., &
Millesi, E. (2004). Seasonal variation in daily activity
patterns of free-ranging European ground squirrels (Spermophilus
citellus). Chronobiology
International, 21(1), 57-71. https://doi.org/10.1081/CBI-120027982
2003
Cooper,
HM., Dkhissi-Benyahya, O., Rieux, C., Hut, R., &
de Vanssay, W. (2003). A new cone in human retina.
Investigative ophthalmology & visual
science, 44, U67-U67.
Sandovici,
M., Henning, RH., Hut, RA.,
Strijkstra, AM., Epema, AE., van Goor, H., &
Deelman, LE. (2003). Differential regulation of
glomerular and interstitial endothelial nitric oxide synthase
during mammalian hibernation. Journal of the
American Society of Nephrology, 14,
614A-614A.
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