Hut, Prof. Roelof

Roelof Hut is Professor of Chronobiology at the Faculty of Science and Engineering. His research is primarily focused on chronobiology, a field of biology that centres on studying the body's biorhythms, such as nutrient intake, physical and mental activity, the quality and duration of sleep, and weight regulation. Hut primarily concentrates on the evolutionary, ecological, and neurobiological aspects of these biorhythms. Initially, he mainly studied mammals, but in recent years he has expanded his work to include projects with birds, insects, and humans. Due to his broad interest in all aspects of chronobiology, his work provides a solid foundation for the breadth and diversity of the field.

Among other things, Hut is concerned with the influence of the changing of clocks in spring on our sleep rhythm. Our circadian rhythm is determined by our biological clock, which in turn is influenced by the solar time. The sun is our main source of light and to a large extent determines when we want to go to sleep. According to Hut, daylight saving time causes our biological clock to be two hours off, which prompts us to set our alarm clock regularly. He points out that setting an alarm clock by definition causes sleep deprivation, which is why he and a number of other researchers are calling for the abolition of daylight saving time.

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Publications

2024

McDowell, R. J., Didikoglu, A., Woelders, T., Gatt, M. J., Moffatt, F., Notash, S., Hut, R. A., Brown, T. M., & Lucas, R. J. (2024). Beyond Lux: methods for species and photoreceptor-specific quantification of ambient light for mammals. BMC Biology, 22(1), Article 257. https://doi.org/10.1186/s12915-024-02038-1

van Rosmalen, L., Deota, S., Maier, G., Le, H. D., Lin, T., Ramasamy, R. K., Hut, R. A., & Panda, S. (2024). Energy balance drives diurnal and nocturnal brain transcriptome rhythms. Cell reports, 43(3), Article 113951. https://doi.org/10.1016/j.celrep.2024.113951

Kong, X., Meerlo, P., & Hut, R. A. (2024). Melatonin does not affect the stress-induced phase shifts of peripheral clocks in male mice. Endocrinology (United States), 165(1), Article bqad183. https://doi.org/10.1210/endocr/bqad183

van Rosmalen, L., Zhu, J., Maier, G., Gacasan, E. G., Lin, T., Zhemchuzhnikova, E., Rothenberg, V., Razu, S., Deota, S., Ramasamy, R. K., Sah, R. L., McCulloch, A. D., Hut, R. A., & Panda, S. (2024). Multi-organ transcriptome atlas of a mouse model of relative energy deficiency in sport. Cell Metabolism, 36(9), 2015-2037. https://doi.org/10.1016/j.cmet.2024.08.001

Lucas, R. J., Allen, A. E., Brainard, G. C., Brown, T. M., Dauchy, R. T., Didikoglu, A., Do, M. T. H., Gaskill, B. N., Hattar, S., Hawkins, P., Hut, R. A., McDowell, R. J., Nelson, R. J., Prins, J. B., Schmidt, T. M., Takahashi, J. S., Verma, V., Voikar, V., Wells, S., & Peirson, S. N. (2024). Recommendations for measuring and standardizing light for laboratory mammals to improve welfare and reproducibility in animal research. PLOS BIOLOGY, 22(3 March), Article e3002534. https://doi.org/10.1371/journal.pbio.3002535

van Doorn, G. S., Schepers, J., Hut, R. A., & Groot, A. T. (2024). Sex-specific expression of circadian rhythms enables allochronic speciation. Evolution Letters, Article qrae049. Advance online publication. https://doi.org/10.1093/evlett/qrae049

2023

Wang, Y., Jin, L., Belušič, G., Beukeboom, L. W., Wertheim, B., & Hut, R. A. (2024). Circadian entrainment to red-light Zeitgebers and action spectrum for entrainment in the jewel wasp Nasonia vitripennis. Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology, 210, 459–472. https://doi.org/10.1007/s00359-023-01672-4

Floessner, T. S. E., Benetta, E. D., Beersma, D. G. M., & Hut, R. A. (2024). Variation in photoperiod response corresponds to differences in circadian light sensitivity in northern and southern Nasonia vitripennis lines. Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology, 210, 667-676. https://doi.org/10.1007/s00359-023-01674-2

Kong, X., Luxwolda, M., Hut, R. A., & Meerlo, P. (2023). Adrenalectomy prevents the effects of social defeat stress on PER2 rhythms in some peripheral tissues in male mice. Hormones and Behavior, 150, Article 105326. https://doi.org/10.1016/j.yhbeh.2023.105326

van Dalum, M. J., van Rosmalen, L., Appenroth, D., Cazarez Marquez, F., Roodenrijs, R. T. M., de Wit, L., Hut, R. A., & Hazlerigg, D. G. (2023). Ambient temperature effects on the spring and autumn somatic growth trajectory show plasticity in the photoneuroendocrine response pathway in the tundra vole. Journal of Biological Rhythms, 38(6), 586–600. https://doi.org/10.1177/07487304231190156

Wang, Y., Belušič, G., Pen, I., Beukeboom, L. W., Wertheim, B., Stavenga, D. G., & Hut, R. A. (2023). Circadian rhythm entrainment of the jewel wasp, Nasonia vitripennis, by antagonistic interactions of multiple spectral inputs. Proceedings of the Royal Society B, 290(1992), Article 20222319. https://doi.org/10.1098/rspb.2022.2319

Giménez, M. C., Luxwolda, M., Van Stipriaan, E. G., Bollen, P. P., Hoekman, R. L., Koopmans, M. A., Arany, P. R., Krames, M. R., Berends, A. C., Hut, R. A., & Gordijn, M. C. M. (2023). Effects of near-infrared light on well-being and health in human subjects with mild sleep-related complaints: A double-blind, randomized, placebo-controlled study. Biology, 12(1), Article 60. https://doi.org/10.3390/biology12010060

Woelders, T., Revell, V. L., Middleton, B., Ackermann, K., Kayser, M., Raynaud, F. I., Skene, D. J., & Hut, R. A. (2023). Machine learning estimation of human body time using metabolomic profiling. Proceedings of the National Academy of Sciences of the United States of America, 120(18), Article e2212685120. https://doi.org/10.1073/pnas.2212685120

van Rosmalen, L., Schepers, R., Hao, W., Przybylska-Piech, A. S., Herman, J. S., Stojak, J., Wójcik, J. M., van de Zande, L., Searle, J. B., & Hut, R. A. (2023). Seasonal adaptation: Geographic photoperiod-temperature patterns explain genetic variation in the common vole Tsh receptor. Genes, 14(2), Article 292. https://doi.org/10.3390/genes14020292

de Wit, L., Hamberg, M. R., Ross, A. M., Goris, M., Lie, F. F., Ruf, T., Giroud, S., Henning, R. H., & Hut, R. A. (2023). Temperature effects on DNA damage during hibernation. Physiological and Biochemical Zoology, 96(2), 144-152. https://doi.org/10.1086/722904

Wang, Y., Beukeboom, L. W., Wertheim, B., & Hut, R. A. (2023). Transcriptomic analysis of light-induced genes in Nasonia vitripennis: Possible implications for circadian light entrainment pathways. Biology, 12(9), Article 1215. https://doi.org/10.3390/biology12091215

2022

Lok, R., Woelders, T., van Koningsveld, M. J., Oberman, K., Fuhler, S. G., Beersma, D. G. M., & Hut, R. A. (2022). Bright light decreases peripheral skin temperature in healthy men: A forced desynchrony study under dim and bright light (II). Journal of Biological Rhythms, 37(4), 417-428. https://doi.org/10.1177/07487304221096948

Lok, R., Woelders, T., Gordijn, M. C. M., van Koningsveld, M. J., Oberman, K., Fuhler, S. G., Beersma, D. G. M., & Hut, R. A. (2022). Bright light during wakefulness improves sleep quality in healthy men: A forced desynchrony study under dim and bright light (III). Journal of Biological Rhythms, 37(4), 429-441. https://doi.org/10.1177/07487304221096910

Lok, R., Woelders, T., van Koningsveld, M. J., Oberman, K., Fuhler, S. G., Beersma, D. G. M., & Hut, R. A. (2022). Bright light increases alertness and not cortisol in healthy men: A forced desynchrony study under dim and bright light (I). Journal of Biological Rhythms, 37(4), 403–416. https://doi.org/10.1177/07487304221096945

Kong, X., Ota, S. M., Suchecki, D., Lan, A., Peereboom, A. I., Hut, R. A., & Meerlo, P. (2022). Chronic social defeat stress shifts peripheral circadian clocks in male mice in a tissue-specific and time-of-day dependent fashion. Journal of Biological Rhythms, 37(2), 164-176. https://doi.org/10.1177/07487304211065336

van Rosmalen, L., Riedstra, B., Beemster, N., Dijkstra, C., & Hut, R. A. (2022). Differential temperature effects on photoperiodism in female voles: A possible explanation for declines in vole populations. Molecular Ecology, 31(12), 3360-3373. https://doi.org/10.1111/mec.16467

van Rosmalen, L., Riede, S. J., Pilorz, V., Adage, T., Scheurink, A. J. W., van der Vinne, V., & Hut, R. A. (2022). Nocturnal and diurnal behavior assessed by the “work-for-food” protocol in small rodents. In T. Hirota, M. Hatori, & S. Panda (Eds.), Circadian Clocks (pp. 187-216). (Neuromethods; Vol. 186). Humana Press. https://doi.org/10.1007/978-1-0716-2577-4_9

van Dis, N. E., Risse, J. E., Pijl, A. S., Hut, R. A., Visser, M. E., & Wertheim, B. (2022). Transcriptional regulation underlying the temperature response of embryonic development rate in the winter moth. Molecular Ecology, 31(22), 5795-5812. https://doi.org/10.1111/mec.16705

2021

van Hasselt, S. J., Hut, R. A., Allocca, G., Vyssotski, A. L., Piersma, T., Rattenborg, N. C., & Meerlo, P. (2021). Cloud cover amplifies the sleep-suppressing effect of artificial light at night in geese. Environmental Pollution, 273, Article 116444. https://doi.org/10.1016/j.envpol.2021.116444

van Rosmalen, L., & Hut, R. A. (2021). Food and temperature change photoperiodic responses in two vole species. The Journal of Experimental Biology, 224(23). https://doi.org/10.1242/jeb.243030

van Rosmalen, L., van Dalum, J., Appenroth, D., Roodenrijs, R. T. M., de Wit, L., Hazlerigg, D. G., & Hut, R. A. (2021). Mechanisms of temperature modulation in mammalian seasonal timing. The FASEB Journal, 35(5), Article e21605. https://doi.org/10.1096/fj.202100162R

van Rosmalen, L., & Hut, R. A. (2021). Negative energy balance enhances ultradian rhythmicity in spring-programmed voles. Journal of Biological Rhythms, 36(4), 359-368. https://doi.org/10.1177/07487304211005640

Homberg, J. R., Adan, R. A. H., Alenina, N., Asiminas, A., Bader, M., Beckers, T., Begg, D. P., Blokland, A., Burger, M. E., van Dijk, G., Eisel, U. L. M., Elgersma, Y., Englitz, B., Fernandez-Ruiz, A., Fitzsimons, C. P., van Dam, A.-M., Gass, P., Grandjean, J., Havekes, R., ... Genzel, L. (2021). The continued need for animals to advance brain research. Neuron, 109(15), 2374-2379. https://doi.org/10.1016/j.neuron.2021.07.015

Ota, S. M., Kong, X., Hut, R., Suchecki, D., & Meerlo, P. (2021). The impact of stress and stress hormones on endogenous clocks and circadian rhythms. Frontiers in Neuroendocrinology, 63, Article 100931. https://doi.org/10.1016/j.yfrne.2021.100931

van Dis, N. E., van der Zee, M., Hut, R. A., Wertheim, B., & Visser, M. E. (2021). Timing of increased temperature sensitivity coincides with nervous system development in winter moth embryos. The Journal of Experimental Biology, 224(17), Article jeb242554. https://doi.org/10.1242/jeb.242554

2020

Lok, R., Zerbini, G., Gordijn, M. C. M., Beersma, D. G. M., & Hut, R. A. (2020). Gold, silver or bronze: Circadian variation strongly affects performance in Olympic athletes. Scientific Reports, 10(1), Article 16088. https://doi.org/10.1038/s41598-020-72573-8

van Rosmalen, L., van Dalum, J., Hazlerigg, D. G., & Hut, R. A. (2020). Gonads or body? Differences in gonadal and somatic photoperiodic growth response in two vole species. The Journal of Experimental Biology, 223. https://doi.org/10.1242/jeb.230987

Ota, S. M., Hut, R. A., Riede, S. J., Crosby, P., Suchecki, D., & Meerlo, P. (2020). Social stress and glucocorticoids alter PERIOD2 rhythmicity in the liver, but not in the suprachiasmatic nucleus. Hormones and Behavior, 120, Article 104683. https://doi.org/10.1016/j.yhbeh.2020.104683

2019

Lok, R., van Koningsveld, M. J., Gordijn, M. C. M., Beersma, D. G. M., & Hut, R. A. (2019). Daytime melatonin and light independently affect human alertness and body temperature. Journal of Pineal Research, 67(1), Article e12583. https://doi.org/10.1111/jpi.12583

Wang, D., Li, N., Tian, L., Ren, F., Li, Z., Chen, Y., Liu, L., Hu, X., Zhang, X., Song, Y., Hut, R. A., & Liu, X.-H. (2019). Dynamic expressions of hypothalamic genes regulate seasonal breeding in a natural rodent population. Molecular Ecology, 28(15), 3508-3522. https://doi.org/10.1111/mec.15161

Floessner, T. S. E., Boekelman, F. E., Druiven, S. J. M., de Jong, M., Rigter, P. M. F., Beersma, D. G. M., & Hut, R. A. (2019). Lifespan is unaffected by size and direction of daily phase shifts in Nasonia, a hymenopteran insect with strong circadian light resetting. Journal of Insect Physiology, 117, Article 103896. https://doi.org/10.1016/j.jinsphys.2019.103896

Salis, L., Caro, S. P., Hut, R. A., Vernooij, L., & Visser, M. E. (2019). Manipulation of photoperiod perception advances gonadal growth but not laying date in the great tit. Journal of Avian Biology, 50(10), Article 02197. https://doi.org/10.1111/jav.02197

van der Vinne, V., Tachinardi, P., Riede, S. J., Akkerman, J., Scheepe, J., Daan, S., & Hut, R. A. (2019). Maximising survival by shifting the daily timing of activity. Ecology Letters, 22(12), 2097-2102. https://doi.org/10.1111/ele.13404

van Dis, N. E., van der Zee, M., Hut, R. A., Wertheim, B., & Visser, M. (2019). Winter moth adaptation to climate change: Genetic changes in thermal plasticity of embryonic development rate. Poster session presented at ESEB 2019, Turku, Finland.

van Dis, N. E., van der Zee, M., Hut, R. A., Wertheim, B., & Visser, M. (2019). Winter moth (Operophtera brumata) adaptation to climate change: Embryonic response to temperature. Poster session presented at Netherlands Society for Evolutionary Biology Meeting 2019, Ede, Netherlands.

2018

Woelders, T., Leenheers, T., Gordijn, M. C. M., Hut, R. A., Beersma, D. G. M., & Wams, E. J. (2018). Correction for Woelders et al., Melanopsin- and L-cone–induced pupil constriction is inhibited by S- and M-cones in humans. Proceedings of the National Academy of Science of the United States of America, 115(9), Article E2147. https://doi.org/10.1073/pnas.1801001115

Woelders, T., Wams, E. J., Gordijn, M. C. M., Beersma, D. G. M., & Hut, R. A. (2018). Integration of color and intensity increases time signal stability for the human circadian system when sunlight is obscured by clouds. Scientific Reports, 8(1), Article 15214. https://doi.org/10.1038/s41598-018-33606-5

Woelders, T., Leenheers, T., Gordijn, M. C. M., Hut, R. A., Beersma, D. G. M., & Wams, E. J. (2018). Melanopsin- and L-cone-induced pupil constriction is inhibited by S- and M-cones in humans. Proceedings of the National Academy of Science of the United States of America, 115(4), 792-797. https://doi.org/10.1073/pnas.1716281115

Trillmich, F., von Engelhardt, N., & Hut, R. A. (2018). Obituary: Professor Serge Daan (11 June 1940-9 February 2018). Ethology, 124(5), 279-280. https://doi.org/10.1111/eth.12742

Hut, R. A., Gerkema, M. P., Beersma, D. G. M., & Tinbergen, J. M. (2018). Serge Daan In Memoriam. Journal of Biological Rhythms, 33(2), 111-116. https://doi.org/10.1177/0748730418768594

Lok, R., Woelders, T., Gordijn, M. C. M., Hut, R. A., & Beersma, D. G. M. (2018). White light during daytime does not improve alertness in well-rested individuals. Journal of Biological Rhythms, 33(6), 637-648. https://doi.org/10.1177/0748730418796036

2017

Lech, K., Liu, F., Davies, S. K., Ackermann, K., Ang, J. E., Middleton, B., Revell, V. L., Raynaud, F. I., Hoveijn, I., Hut, R. A., Skene, D. J., & Kayser, M. (2018). Erratum to: investigation of metabolites for estimating blood deposition time. International journal of legal medicine, 132(1), 33. https://doi.org/10.1007/s00414-017-1670-y

Lech, K., Liu, F., Davies, S. K., Ackermann, K., Ang, J. E., Middleton, B., Revell, V. L., Raynaud, F. J., Hoveijn, I., Hut, R. A., Skene, D. J., & Kayser, M. (2018). Investigation of metabolites for estimating blood deposition time. International journal of legal medicine, 132, 25-32. https://doi.org/10.1007/s00414-017-1638-y

Salis, L., van den Hoorn, E., Beersma, D. G. M., Hut, R. A., & Visser, M. E. (2018). Photoperiodic cues regulate phenological carry-over effects in an herbivorous insect. Functional Ecology, 32(1), 171-180. https://doi.org/10.1111/1365-2435.12953

Hut, R., & Floessner, T. (2017). Basic principles underlying biological oscillations and their entrainment. In V. Kumar (Ed.), Biological Timekeeping: Clocks, Rhythms and Behaviour (pp. 47-58). Springer India. https://doi.org/10.1007/978-81-322-3688-7_3

Woelders, T., Beersma, D. G. M., Gordijn, M. C. M., Hut, R. A., & Wams, E. J. (2017). Daily light exposure patterns reveal phase and period of the human circadian clock. Journal of Biological Rhythms, 32(3), 274-286. https://doi.org/10.1177/0748730417696787

van der Veen, D. R., Riede, S. J., Heideman, P. D., Hau, M., van der Vinne, V., & Hut, R. A. (2017). Flexible clock systems: Adjusting the temporal programme. Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 372(1734), Article 20160254. https://doi.org/10.1098/rstb.2016.0254

Wams, E. J., Woelders, T., Marring, I., van Rosmalen, L., Beersma, D. G. M., Gordijn, M. C. M., & Hut, R. A. (2017). Linking light exposure and subsequent sleep: A field polysomnography study in humans. Sleep, 40(12), Article zsx165. https://doi.org/10.1093/sleep/zsx165

Wams, E. J., Riede, S. J., van der Laan, I., ten Bulte, T., & Hut, R. A. (2017). Mechanisms of non-photic entrainment. In V. Kumar (Ed.), Biological Timekeeping: Clocks, Rhythms and Behaviour (pp. 395-404). Springer India. https://doi.org/10.1007/978-81-322-3688-7_18

Riede, S. J., van der Vinne, V., & Hut, R. A. (2017). The flexible clock: Predictive and reactive homeostasis, energy balance and the circadian regulation of sleep-wake timing. Journal of Experimental Biology, 220(5), 738-749. https://doi.org/10.1242/jeb.130757

Hau, M., Dominoni, D., Casagrande, S., Buck, C. L., Wagner, G., Hazlerigg, D., Greives, T., & Hut, R. A. (2017). Timing as a sexually selected trait: The right mate at the right moment. Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 372(1734), Article 20160249. https://doi.org/10.1098/rstb.2016.0249

2015

van der Vinne, V., Gorter, J. A., Riede, S. J., & Hut, R. A. (2015). Diurnality as an energy-saving strategy: Energetic consequences of temporal niche switching in small mammals. Journal of Experimental Biology, 218(16), 2585-93. https://doi.org/10.1242/jeb.119354

van der Vinne, V., Akkerman, J., Lanting, G. D., Riede, S. J., & Hut, R. A. (2015). Food reward without a timing component does not alter the timing of activity under positive energy balance. Neuroscience, 304, 260-265. https://doi.org/10.1016/j.neuroscience.2015.07.061

van der Vinne, V., Zerbini, G., Siersema, A., Pieper, A., Merrow, M., Hut, R. A., Roenneberg, T., & Kantermann, T. (2015). Timing of examinations affects school performance differently in early and late chronotypes. Journal of Biological Rhythms, 30(1), 53-60. https://doi.org/10.1177/0748730414564786

2014

van der Vinne, V., Riede, S. J., Gorter, J. A., Eijer, W. G., Sellix, M. T., Menaker, M., Daan, S., Pilorz, V., & Hut, R. A. (2014). Cold and hunger induce diurnality in a nocturnal mammal. Proceedings of the National Academy of Sciences of the United States of America, 111(42), 15256-60. https://doi.org/10.1073/pnas.1413135111

Ensing, E. P., Ciuti, S., de Wijs, F. A. L. M., Lentferink, D. H., Ten Hoedt, A., Boyce, M. S., & Hut, R. A. (2014). GPS based daily activity patterns in European red deer and North American elk (Cervus elaphus): Indication for a weak circadian clock in ungulates. PLoS ONE, 9(9), Article 106997. https://doi.org/10.1371/journal.pone.0106997

Hut, R. A., Dardente, H., & Riede, S. J. (2014). Seasonal timing: How does a hibernator know when to stop hibernating? Current Biology, 24(13), R602-R605. https://doi.org/10.1016/j.cub.2014.05.061

2013

Helm, B., Ben-Shlomo, R., Sheriff, M. J., Hut, R. A., Foster, R., Barnes, B. M., & Dominoni, D. (2013). Annual rhythms that underlie phenology: Biological time-keeping meets environmental change. Proceedings of the Royal Society B, 280(1765), Article 20130016. https://doi.org/10.1098/rspb.2013.0016

Hut, R. A., Paolucci, S., Dor, R., Kyriacou, C. P., & Daan, S. (2013). Latitudinal clines: An evolutionary view on biological rhythms. Proceedings of the Royal Society B, 280(1765), Article 20130433. https://doi.org/10.1098/rspb.2013.0433

Caro, S. P., Schaper, S. V., Hut, R. A., Ball, G. F., & Visser, M. E. (2013). The case of the missing mechanism: How does temperature influence seasonal timing in endotherms? PLOS BIOLOGY, 11(4), Article e1001517. https://doi.org/10.1371/journal.pbio.1001517

Gerkema, M. P., Davies, W. I. L., Foster, R. G., Menaker, M., & Hut, R. A. (2013). The nocturnal bottleneck and the evolution of activity patterns in mammals. Proceedings of the Royal Society B, 280(1765), Article 20130508. https://doi.org/10.1098/rspb.2013.0508

Mulder, C., van der Zee, E. A., Hut, R. A., & Gerkema, M. P. (2013). Time-place learning and memory persist in mice lacking functional Per1 and Per2 clock genes. Journal of Biological Rhythms, 28(6), 367-379. https://doi.org/10.1177/0748730413512958

2012

Hut, R. A., Kronfeld-Schor, N., van der Vinne, V., & De la Iglesia, H. (2012). In search of a temporal niche: Environmental factors. In The Neurobiology of Circadian Timing (Vol. 199, pp. 281-304). (Progress in Brain Research; Vol. 199). Elsevier. https://doi.org/10.1016/B978-0-444-59427-3.00017-4

Strijkstra, A. M., Koopmans, T., Bouma, H. R., Boer, S. F. D., Hut, R. A., & Boerema, A. S. (2012). On the Dissimilarity of 5′-AMP Induced Hypothermia and Torpor in Mice. In W. Arnold, C. Bieber, E. Millesi, & T. Ruf (Eds.), Living in a Seasonal World: Thermoregulatory and Metabolic Adaptations (pp. 351-362). Springer Verlag. https://doi.org/10.1007/978-3-642-28678-0_31

Krol, E., Douglas, A., Dardente, H., Birnie, M. J., van der Vinne, V., Eijer, W. G., Gerkema, M. P., Hazlerigg, D. G., Hut, R. A., & Król, E. (2012). Strong pituitary and hypothalamic responses to photoperiod but not to 6-methoxy-2-benzoxazolinone in female common voles (Microtus arvalis). General and Comparative Endocrinology, 179(2), 289-295. https://doi.org/10.1016/j.ygcen.2012.09.004

2011

Hut, R. A., & Beersma, D. G. M. (2011). Evolution of time-keeping mechanisms: early emergence and adaptation to photoperiod. Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 366(1574), 2141-2154. https://doi.org/10.1098/rstb.2010.0409

Hut, R. A. (2011). Photoperiodism: Shall EYA Compare Thee to a Summer's Day? Current Biology, 21(1), R22-R25. https://doi.org/10.1016/j.cub.2010.11.060

Hut, R. A., & van der Zee, E. A. (2011). The cholinergic system, circadian rhythmicity, and time memory. Behavioral Brain Research, 221(2), 466-480. https://doi.org/10.1016/j.bbr.2010.11.039

Hut, R. A., Pilorz, V., Boerema, A. S., Strijkstra, A. M., & Daan, S. (2011). Working for Food Shifts Nocturnal Mouse Activity into the Day. PLoS ONE, 6(3), Article 17527. https://doi.org/10.1371/journal.pone.0017527

2010

Bouma, H. R., Strijkstra, A. M., Boerema, A. S., Deelman, L. E., Epema, A. H., Hut, R. A., Kroese, F. G. M., & Henning, R. H. (2010). Blood cell dynamics during hibernation in the European Ground Squirrel. Veterinary Immunology and Immunopathology, 136(3-4), 319-323. https://doi.org/10.1016/j.vetimm.2010.03.016

Roenneberg, T., Hut, R., Daan, S., & Merrow, M. (2010). Entrainment Concepts Revisited. Journal of Biological Rhythms, 25(5), 329-339. https://doi.org/10.1177/0748730410379082

2009

Daan, S., Comas, M., Spoelstra, K., Hut, R., & Beersma, D. (2009). Circadian entrainment by different daylengths: The roles of dawn and dusk. Sleep Science, 2(4), 7.

Sosniyenko, S., Hut, R. A., Daan, S., & Sumova, A. (2009). Influence of photoperiod duration and light-dark transitions on entrainment of Per1 and Per2 gene and protein expression in subdivisions of the mouse suprachiasmatic nucleus. European Journal of Neuroscience, 30(9), 1802-1814. https://doi.org/10.1111/j.1460-9568.2009.06945.x

van der Zee, E. A., Boersma, G. J., & Hut, R. A. (2009). The neurobiology of circadian rhythms. Current Opinion in Pulmonary Medicine, 15(6), 534-539. https://doi.org/10.1097/MCP.0b013e3283319b29

Beersma, D. G. M., Comas, M., Hut, R. A., Gordijn, M. C. M., Rueger, M., & Daan, S. (2009). The progression of circadian phase during light exposure in animals and humans. Journal of Biological Rhythms, 24(2), 153-160. https://doi.org/10.1177/0748730408330196

Comas, M., & Hut, R. A. (2009). Twilight and Photoperiod Affect Behavioral Entrainment in the House Mouse (Mus musculus). Journal of Biological Rhythms, 24(5), 403-412. https://doi.org/10.1177/0748730409343873

2008

Comas, M., Beersma, D. G. M., Hut, R. A., & Daan, S. (2008). Circadian phase resetting in response to light-dark and dark-light transitions. Journal of Biological Rhythms, 23(5), 425-434. https://doi.org/10.1177/0748730408321567

van der Zee, E. A., Havekes, R., Barf, R. P., Hut, R. A., Nijholt, I. M., Jacobs, E. H., & Gerkema, M. P. (2008). Circadian time-place learning in mice depends on Cry genes. Current Biology, 18(11), 844-848. https://doi.org/10.1016/j.cub.2008.04.077

Cameron, M. A., Barnard, A. R., Hut, R. A., Bonnefont, X., van der Horst, G. T. J., Hankins, M. W., & Lucas, R. J. (2008). Electroretinography of Wild-Type and Cry Mutant Mice Reveals Circadian Tuning of Photopic and Mesopic Retinal Responses. Journal of Biological Rhythms, 23(6), 489-501. https://doi.org/10.1177/0748730408325874

Beersma, D. G. M., van Bunnik, B. A. D., Hut, R. A., & Daan, S. (2008). Emergence of circadian and photoperiodic system level properties from interactions among pacemaker cells. Journal of Biological Rhythms, 23(4), 362-373. https://doi.org/10.1177/0748730408317992

Oklejewicz, M., Destici, E., Tamanini, F., Hut, R. A., Janssens, R., & van der Horst, G. T. J. (2008). Phase resetting of the mammalian circadian clock by DNA damage. Current Biology, 18(4), 286-291. https://doi.org/10.1016/j.cub.2008.01.047

Hut, R. A., Oklejewicz, M., Rieux, C., & Cooper, H. M. (2008). Photic sensitivity ranges of hamster pupillary and circadian phase responses do not overlap. Journal of Biological Rhythms, 23(1), 37-48. https://doi.org/10.1177/0748730407311851

Veen, D. R. V. D., Mulder, E. G. A., Oster, H., Gerkema, M. P., & Hut, R. A. (2008). SCN-AVP release of mPer1/mPer2 double-mutant mice in vitro. Journal of Circadian Rhythms, 6(1). https://doi.org/10.1186/1740-3391-6-5

2007

Rüdiger, J., van der Zee, E. A., Strijkstra, A. M., Aschoff, A., Daan, S., & Hut, R. A. (2007). Dynamics in the ultrastructure of asymmetric axospinous synapses in the frontal cortex of hibernating European ground squirrels (Spermophilus citellus). Synapse, 61(5), 343-352. https://doi.org/10.1002/syn.20380

Drouyer, E., Rieux, C., Hut, R. A., & Cooper, H. M. (2007). Responses of suprachiasmatic nucleus neurons to light and dark adaptation: Relative contributions of melanopsin and rod-cone inputs. The Journal of Neuroscience, 27(36), 9623-9631. https://doi.org/10.1523/JNEUROSCI.1391-07.2007

Long, R. A., Hut, R. A., & Barnes, B. M. (2007). Simultaneous collection of body temperature and activity data in burrowing mammals: a new technique. Journal of wildlife management, 71(4), 1375-1379. https://doi.org/10.2193/2006-399

2006

Lincoln, G. A., Clarke, I. J., Hut, R. A., & Hazlerigg, D. G. (2006). Characterizing a mammalian circannual pacemaker. Science, 314(5807), 1941-1944. https://doi.org/10.1126/science.1132009

Dkhissi-Benyahya, O., Rieux, C., Hut, R. A., & Cooper, H. M. (2006). Immunohistochemical evidence of a melanopsin cone in human retina. Investigative ophthalmology & visual science, 47(4), 1636-1641. https://doi.org/10.1167/iovs.05-1459

Oster, H., Damerow, S., Hut, R. A., & Eichele, G. (2006). Transcriptional Profiling in the Adrenal Gland Reveals Circadian Regulation of Hormone Biosynthesis Genes and Nucleosome Assembly Genes. Journal of Biological Rhythms, 21(5), 350-361. https://doi.org/10.1177/0748730406293053

2004

Sandovici, M., Henning, RH., Hut, RA., Strijkstra, AM., Epema, AH., van Goor, H., & Deelman, LE. (2004). Differential regulation of glomerular and interstitial endothelial nitric oxide synthase expression in the kidney of hibernating ground squirrel. Nitric oxide-Biology and chemistry, 11(2), 194-200. https://doi.org/10.1016/j.niox.2004.08.002

Cooper, HM., Chiquet, C., Rieux, C., Hut, RA., Gronfier, C., Claustrat, B., Brun, J., & Denis, P. (2004). Mid-wavelength monochromatic light is more effective for suppressing plasma melatonin in humans than broadband white light. Investigative ophthalmology & visual science, 45, U426-U426.

Chiquet, C., Gronfier, C., Rieux, C., Hut, RA., Claustrat, B., Brun, J., Denis, P., & Cooper, HM. (2004). Reduced sensitivity to light suppression of nocturnal plasma melatonin in glaucoma patients. Investigative ophthalmology & visual science, 45, U425-U425.

Everts, LG., Strijkstra, AM., Hut, RA., Hoffmann, IE., & Millesi, E. (2004). Seasonal variation in daily activity patterns of free-ranging European ground squirrels (Spermophilus citellus). Chronobiology International, 21(1), 57-71. https://doi.org/10.1081/CBI-120027982

2003

Cooper, HM., Dkhissi-Benyahya, O., Rieux, C., Hut, R., & de Vanssay, W. (2003). A new cone in human retina. Investigative ophthalmology & visual science, 44, U67-U67.

Sandovici, M., Henning, RH., Hut, RA., Strijkstra, AM., Epema, AE., van Goor, H., & Deelman, LE. (2003). Differential regulation of glomerular and interstitial endothelial nitric oxide synthase during mammalian hibernation. Journal of the American Society of Nephrology, 14, 614A-614A.

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