Wijmenga, prof. dr. Cisca
Prof.dr. Cisca Wijmenga is sinds 2007 hoogleraar Humane Genetica aan de Rijksuniversiteit Groningen en hoofd van de afdeling Genetica van het Universitair Medisch Centrum Groningen. Met haar onderzoek probeert ze inzicht te krijgen in de genen die een rol spelen bij het ontstaan van chronische ziekten. Haar onderzoeksgroep richt zich daarbij met name op de genetica van ontstekingsgerelateerde aandoeningen, zoals coeliakie (gluten allergie) en inflammatoire darmziekten (ziekte van Crohn, ulceratieve colitis), maar ook chronische ziekten als diabetes en reuma. Onder haar leiding zijn meerdere genen gevonden die een rol spelen bij het ontstaan van dergelijke immuun-gerelateerde aandoeningen. Deze kennis leidt tot nieuwe inzichten in het ziekte proces en kan mogelijk leiden tot nieuwe behandelingen voor patiënten.
Sinds 2012 is Wijmenga lid van de Koninklijke Nederlandse Akademie van Wetenschappen (KNAW). Leden van de KNAW zijn allen vooraanstaande wetenschappers uit alle disciplines en worden gekozen op grond van voordrachten van binnen en buiten de Akademie. In het hetzelfde jaar ontving ze een prestigieuze ERC Advanced Grant voor haar onderzoek naar gluten en glutenallergie. BBMRI-NL2.0, het samenwerkingsverband tussen biobanken in Nederland waarvan Wijmenga directeur is, ontving in 2014 9,8 miljoen euro van NWO. In 2015 is aan Wijmenga de prestigieuze Spinozapremie toegekend, ook wel de 'Nederlandse Nobelprijs' genoemd. In 2017 werd een Zwaartekrachtsubsidie toegekend voor onderzoek naar ‘organen op een chip’ waarvan Wijmenga een van de trekkers is. Door middel van een ‘darm-op-een-chip’ kan ze niet alleen diepgaander onderzoek naar coeliakie doen, maar ook de rol van darmbacteriën in ziekte en gezondheid bestuderen.
Het werk van Wijmenga heeft ook veel betekenis voor de klinische praktijk. Zij is bijna tien jaar afdelingshoofd Genetica geweest en heeft in die tijd het klinisch en wetenschappelijk genetisch werk volledig geïntegreerd. Mede door haar inzet is de doorlooptijd van klinisch genetische bepalingen sterk ingekort waardoor in toenemende mate het klinisch genetische beeld vroeg in de diagnostiek kan worden toegepast. Daarnaast ontplooide ze met haar team veel initiatieven ter popularisering van de genetica, de epidemiologie en het life science onderzoek in bredere zin.
Van 2019 - 2023 was Wijmenga rector magnificus van de RUG. Ze was de eerste vrouwelijke rector in het 405-jarige bestaan van de universiteit.
Meer video's
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Wijmenga over de (on)mogelijkheden van DNA en erfelijkheid (lezing in kader Top of Profs)
Eerder in het nieuws
2024
Moerkens,
R., Mooiweer, J.,
Ramírez-Sánchez, A. D., Oelen,
R., Franke, L., Wijmenga, C.,
Barrett, R. J., Jonkers, I. H., & Withoff,
S. (2024). An iPSC-derived small intestine-on-chip
with self-organizing epithelial, mesenchymal, and neural
cells. Cell reports, 43(7),
Article 114247. https://doi.org/10.1016/j.celrep.2024.114247
Lifelines
Corona Research initiative, Goërtz, Y. M. J., Spruit, M. A.,
Van Herck, M., Dukers-Muijrers, N., van der Kallen, C. J. H.,
Burtin, C., & Janssen, D. J. A. (2024). Author
Correction: Symptoms and quality of life before, during, and after
a SARS-CoV-2 PCR positive or negative test: data from Lifelines
(Scientific Reports, (2023), 13, 1, (11713),
10.1038/s41598-023-38223-5). Scientific
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Fernández-Pato,
A., Sinha, T., Gacesa, R.,
Andreu-Sánchez, S., Gois, M. F. B.,
Gelderloos-Arends, J., Jansen, D. B. H., Kruk, M.,
Jaeger, M., Joosten, L. A. B., Netea, M. G., Weersma, R.
K., Wijmenga, C., Harmsen, H. J.
M., Fu, J., Zhernakova, A.,
& Kurilshikov, A. (2024). Choice of DNA extraction
method affects stool microbiome recovery and subsequent phenotypic
association analyses. Scientific
Reports, 14, Article 3911. https://doi.org/10.1038/s41598-024-54353-w
International
Multiple Sclerosis Genetics Consortium, Lincoln, M. R., Connally,
N., Axisa, P.-P., Gasperi, C., Mitrovic, M., van Heel, D.,
Wijmenga, C., Withoff, S., Jonkers, I.
H., Padyukov, L., Rich, S. S., Graham, R. R., Gaffney, P.
M., Langefeld, C. D., Vyse, T. J., Hafler, D. A., Chun, S.,
Sunyaev, S. R., & Cotsapas, C. (2024). Genetic mapping
across autoimmune diseases reveals shared associations and
mechanisms. Nature genetics,
56(5), 838-845. https://doi.org/10.1038/s41588-024-01732-8
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Cohort Study, Zhernakova, D. V., Wang,
D., Liu, L., Andreu-Sánchez,
S., Zhang, Y., Ruiz-Moreno, A.
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Castillo-Izquierdo, Á., Gacesa, R.,
Lopera-Maya, E. A., Temba, G. S., Kullaya, V. I., van
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H., & Withoff, S. (2024). Human
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Trends in Molecular Medicine. Advance online
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M., Deelen, J., van Meurs, J. B. J., van Dongen, J., Pool, R.,
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Vries, R., Heersema, D. J., Gacesa,
R., Wijmenga, C., Jonkers, I. H.,
Meilof, J. F., & Withoff, S. (2024).
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A., Brushett, S., Kruk, M., Dekens,
J., Sikkema, J., Kuipers, F.,
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A. (2024). Transmission and dynamics of mother-infant
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Nature Communications, 15(1),
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2023
BBJ,
BioMe, BioVU, Canadian Partnership for Tomorrow's Health/OHS, China
Kadoorie Biobank Collaborative Group, Colorado Center for
Personalized Medicine, deCODE Genetics, ESTBB, FinnGen, Generation
Scotland, Genes & Health, LifeLines, Mass General Brigham
Biobank, Michigan Genomics Initiative, QIMR Berghofer Biobank,
Taiwan Biobank, The HUNT Study, UCLA ATLAS Community Health
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V., Sinha, T., Bolte, L. A., Wu,
J., Swertz, M., Kroon, M. L. A. D.,
Reijneveld, S. A., Wijmenga, C., Weersma,
R. K., Fu, J., Loo, H. M.
V., Kurilshikov, A., & Zhernakova,
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Degenhardt, F., Schwerk, M., Hinrichs, O., Jordan-Paiz, A., Padoan,
B., Wegner, L. H. M., Schloer, S., Zecher, B. F., Malsy, J., Joshi,
V. R., Illig, C., Schröder-Schwarz, J., Möller, K. J.,
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Epithelial Cells Enables Tissue Damage by NKp44+ Natural
Killer Cells in Ulcerative Colitis.
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Gois,
M. F. B., Fernández-Pato, A., Huss,
A., Gacesa, R., Wijmenga, C.,
Weersma, R. K., Fu, J., Vermeulen, R. C.
H., Zhernakova, A., Lenters, V. C., &
Kurilshikov, A. (2023). Impact of occupational
pesticide exposure on the human gut microbiome.
Frontiers in Microbiology, 14,
Article 1223120. https://doi.org/10.3389/fmicb.2023.1223120
TANDEM
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Ronacher, K., Riza, A.-L., van Veen, S., Lee,
J.-S., Kumar, V., Kerry-Barnard, S., Malherbe, S. T.,
Kleynhans, L., Stanley, K., Joosten, S. A., Critchley, J. A., Hill,
P. C., van Crevel, R., Wijmenga, C., Haks, M. C., ...
Cliff, J. M. (2023). Impaired resolution of blood
transcriptomes through tuberculosis treatment with diabetes
comorbidity. Clinical and Translational
Medicine, 13(9), Article e1375. https://doi.org/10.1002/ctm2.1375
Palasantzas,
V. E. J. M., Tamargo-Rubio, I., Le,
K., Slager, J., Wijmenga,
C., Jonkers, I. H., Kumar,
V., Fu, J., & Withoff, S.
(2023). iPSC-derived organ-on-a-chip models for personalized
human genetics and pharmacogenomics studies.
Trends in Genetics, 39(4), 268-284.
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eQTLgen
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U., Franke, L., Battle, A., Teumer, A.,
Lehtimäki, T., Raitakari, O. T., Esko, T., Epstein, M. P.,
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A. R., Andreu-Sánchez, S., Vogl, T.,
Hu, S., Vich Vila, A., Gacesa, R.,
Leviatan, S., Kurilshchikov, A., Klompus, S., Kalka,
I. N., van Dullemen, H. M., Weinberger, A.,
Visschedijk, M. C., Festen, E. A. M.,
Faber, K. N., Wijmenga, C., Dijkstra,
G., Segal, E., Fu, J., ... Weersma, R.
K. (2023). Phage-display immunoprecipitation
sequencing of the antibody epitope repertoire in inflammatory bowel
disease reveals distinct antibody signatures.
Immunity, 56(6), 1393-1409.e6. https://doi.org/10.1016/j.immuni.2023.04.017
Lifelines
Cohort Study, Andreu-Sánchez, S.,
Bourgonje, A. R., Vogl, T., Kurilshchikov, A.,
Leviatan, S., Ruiz-Moreno, A. J., Hu,
S., Sinha, T., Vich Vila, A.,
Klompus, S., Kalka, I. N., de Leeuw, K., Arends,
S., Jonkers, I., Withoff,
S., Brouwer, E., Weinberger, A.,
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Phage display sequencing reveals that genetic, environmental,
and intrinsic factors influence variation of human antibody epitope
repertoire. Immunity, 56(6),
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The
Netherlands A. C. M./P. L. N. Registry, Lifelines Cohort
Study, Lopera-Maya, E. A., Li, S.,
de Brouwer, R., Nolte, I. M., van Breen,
J., Jongbloed, J. D. H., Swertz, M.
A., Snieder, H., Franke, L.,
Wijmenga, C., de Boer, R. A., Deelen,
P., van der Zwaag, P. A., & Sanna,
S. (2023). Phenotypic and Genetic Factors Associated
with Absence of Cardiomyopathy Symptoms in PLN:c.40_42delAGA
Carriers. Journal of cardiovascular translational
research, 16, 1251–1266. https://doi.org/10.1007/s12265-022-10347-5
Lifelines
Corona Research initiative, Goërtz, Y. M. J., Spruit, M. A.,
Van Herck, M., Dukers-Muijrers, N., van der Kallen, C. J. H.,
Burtin, C., & Janssen, D. J. A. (2023). Symptoms and
quality of life before, during, and after a SARS-CoV-2 PCR positive
or negative test: data from Lifelines. Scientific
Reports, 13, Article 11713. https://doi.org/10.1038/s41598-023-38223-5
Lifelines
Corona Research initiative, Mobach, M. P., Boezen, H.
M., Mierau, J. O., Franke, H.
L., Dekens, J., Deelen, P.,
Lanting, P., Vonk, J. M., Nolte,
I., Ori, A. P. S., Claringbould,
A., Boulogne, F., Dijkema, M. X. L.,
Wiersma, H. H., Warmerdam, R.,
Jankipersadsing, S. A., van Blokland, I.,
de Bock, G. T. H., ... Wijmenga, C. (2023).
Workplace impact on employees: A Lifelines Corona Research
Initiative on the return to work. PLoS
ONE, 18(1), Article e0279902. https://doi.org/10.1371/journal.pone.0279902
2022
Chu,
X., Janssen, A. W. M., Koenen, H., Chang, L., He, X.,
Joosten, I., Stienstra, R., Kuijpers, Y., Wijmenga,
C., Xu, C.-J., Netea, M. G., Tack, C. J., Li,
Y., & Buettner, C. (2022). A genome-wide
functional genomics approach uncovers genetic determinants of
immune phenotypes in type 1 diabetes.
eLife, 11, Article 73709. https://doi.org/10.7554/eLife.73709
Lifelines
Cohort Study, Lopera-Maya, E. A., Kurilshikov,
A., van der Graaf, A., Hu,
S., Andreu-Sánchez, S., Chen,
L., Vila, A. V., Gacesa, R.,
Sinha, T., Collij, V., Klaassen, M. A.
Y., Bolte, L. A., Gois, M. F. B.,
Neerincx, P. B. T., Swertz, M. A.,
Harmsen, H. J. M., Wijmenga, C., Fu,
J., ... Sanna, S. (2022). Author
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Nature genetics, 54(9), 1448. https://doi.org/10.1038/s41588-022-01164-2
Gulyaeva,
A., Garmaeva, S., Ruigrok, R. A. A. A.,
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C., Weersma, R. K., Fu, J.,
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E. A., Kurilshikov, A., van der Graaf,
A., Hu, S., Lifelines Cohort Study,
Andreu-Sánchez, S., Chen, L., Vila,
A. V., Gacesa, R., Sinha,
T., Collij, V., Klaassen, M. A. Y.,
Bolte, L. A., Brandao Gois, M. F.,
Neerincx, P. B. T., Swertz, M. A.,
Harmsen, H. J. M., Wijmenga, C., Fu,
J., ... Sanna, S. (2022). Effect of host
genetics on the gut microbiome in 7,738 participants of the Dutch
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Cohort Study, Lopera-Maya, E. A., Kurilshikov,
A., van der Graaf, A., Hu,
S., Andreu-Sánchez, S., Chen,
L., Vich-Vila, A., Gacesa,
R., Sinha, T., Collij, V.,
Klassen, M. A. Y., Bolte, L. A., Brandao-Gois,
M. F., Neerincx, P. B. T., Swertz, M.
A., Harmsen, H. J. M., Wijmenga,
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R., Kurilshikov, A., Vich Vila,
A., Sinha, T., Klaassen, M. A. Y., Bolte,
L. A., Andreu-Sánchez, S., Chen,
L., Collij, V., Hu, S.,
Dekens, J. A. M., Lenters, V. C., Björk, J.
R., Swarte, J. C., Swertz, M.
A., Jansen, B. H., Gelderloos-Arends, J.,
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Zhernakova, D. V., Sinha, T.,
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M., Franke, L., Wijmenga,
C., Fu, J., van der Wijst, M. G.
P., Melé, M., Lansdorp, P., &
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Hannon, E., Shireby, G. L., Nabais, M. F., Walker, E. M., van
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deCODE
Genetics, Estonian Biobank, FinnGen, Generation Scotland, Genes
& Health Research Team, LifeLines, Mass General Brigham
Biobank, Michigan Genomics Initiative, National Biobank of Korea,
Penn Medicine BioBank, Qatar Biobank, The QSkin Sun and Health
Study, Taiwan Biobank, The HUNT Study, UCLA ATLAS Community Health
Initiative, Uganda Genome Resource, UK Biobank, Biobank of the
Americas, BioBank Japan Project, ... Sanna, S. (2022).
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A., Douwes, R. M., Collij,
V., Kurilshikov, A., Post, A.,
Klaassen, M. A. Y., Eisenga, M. F., Gomes-Neto,
A. W., Kremer, D., Jansen, B.
H., Knobbe, T. J., Berger, S.
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R., ... Weersma, R. K. (2022). Gut
microbiome dysbiosis is associated with increased mortality after
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Hu, S., Vich Vila, A., Leviatan, S.,
Kurilshchikov, A., Klompus, S., Kalka, I. N., van
Dullemen, H. M., Weinberger, A., Visschedijk, M.
C., Festen, E. A. M., Faber, K.
N., Wijmenga, C., Dijkstra, G.,
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V., Kurilshikov, A., Andreu-Sánchez,
S., Wang, D., Augustijn, H. E., Vich
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inter-individual variation in the human plasma metabolome.
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Z., Kasapi, M., Jonkers, D. M. A. E., Garcia-Perez, I., Vork, L.,
Weerts, Z. Z. R. M., Serrano-Contreras, J. I., Zhernakova,
A., Kurilshikov, A., Scotcher, J., Holmes,
E., Wijmenga, C., Keszthelyi, D., Nicholson, J. K.,
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fecal microbiome–metabolome signatures reflect stress and
serotonin metabolism in irritable bowel syndrome.
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M., Claringbould, A., Porcu, E., Kals, M.,
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Ramírez-Sánchez,
A. D., Chu, X., Modderman, R., Kooy-Winkelaar,
Y., Koletzko, S., Korponay-Szabó, I. R., Troncone, R.,
Wijmenga, C., Mearin, L., Withoff, S.,
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Sequencing of Peripheral Blood Mononuclear Cells From Pediatric
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M., Zhernakova, D. V., C L van den Munckhof,
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