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About us Practical matters How to find us dr. S.W.M. (Sophia) Bruggeman

University Medical Center Groningen

dr. S.W.M. (Sophia) Bruggeman

Rosalind Franklin fellow (scientist, junior group leader)

Faculty of Medical Sciences

Telephone:

+31 50 361 6493

E-mail:

s.w.m.bruggeman umcg.nl

ORCID Research Portal

Research interests

Faculty of Medical Sciences	Telephone:	+31 503619554
E-mail: s.w.m.bruggeman@umcg.nl

Curriculum Vitae

Sophia Bruggeman (The Netherlands, 1979) studied Biology at the University of Nijmegen. As PhD student, she worked at the Netherlands Cancer Institute on the role of Polycomb group genes in brain development and cancer (2008, cum laude). She next moved to King's College London to work on the development of the chick and zebrafish forebrain on a KWF postdoctoral fellowship. This fellowship was completed at the European Research Institute for the Biology of Ageing (ERIBA/University Medical Center Groningen).

After awardance of a Rosalind Franklin fellowship (tenure track position) and a KWF Cancer Research career award, Sophia started her own research group at the department of Pediatric Oncology and Hematology/Pediatrics, UMCG (2014). In 2019, Sophia's research group moved to ERIBA, UMCG. Her research aims at understaning how normal neurodevelopmental processes influence pediatric brain cancer initiation and progression.

Publications

Targeting the reprogrammed metabolism in H3.3K27M pediatric high-grade gliomas

de Camargo Magalhães, E. S., de Bont, E. S. J. M., Bruggeman, S. W. M. & Lima, F. R. S., Aug-2024, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1870, 6, 5 p., 167248.

Research output: Contribution to journal › Article › Academic › peer-review

Chromosomal Instability Characterizes Pediatric Medulloblastoma but Is Not Tolerated in the Developing Cerebellum

Bockaj, I., Martini, T. E., Smit, M. J., Armandari, I., Bakker, B., Wardenaar, R., Meeuwsen-de Boer, T. G. J., Bakker, P. L., Spierings, D. C. J., Hoving, E. W., Guryev, V., Foijer, F. & Bruggeman, S. W. M., 30-Aug-2022, In: International Journal of Molecular Sciences. 23, 17, 15 p., 9852.

Research output: Contribution to journal › Article › Academic › peer-review

The developmental stage of the medulloblastoma cell-of-origin restricts Hedgehog pathway usage and drug sensitivity

Smit, M. J., Martini, T. E. I., Armandari, I., Bočkaj, I., Zomerman, W. W., de Camargo Magalhães, E. S., Siragna, Z., Meeuwsen, T. G. J., Scherpen, F. J. G., Schoots, M. H., Ritsema, M., den Dunnen, W. F. A., Hoving, E. W., Paridaen, J. T. M. L., de Haan, G., Guryev, V. & Bruggeman, S. W. M., Jun-2022, In: Journal of Cell Science. 135, 11, 14 p., jeb258608.

Research output: Contribution to journal › Article › Academic › peer-review

CREB signaling activity correlates with differentiation and survival in medulloblastoma

Armandari, I., Zomerman, W. W., Plasschaert, S. L. A., Smit, M. J., Martini, T. E., Magalhaes, E. S. D. C., Hogeling, S. M., Rozema-Huizinga, G. C., Lourens, H. J., Meeuwsen-de Boer, T. G. J., Scherpen, F. J. G., de Bont, E. S. J. M. & Bruggeman, S. W. M., 9-Aug-2021, In: Scientific Reports. 11, 1, 12 p., 16077.

Research output: Contribution to journal › Article › Academic › peer-review

Heat Shock Factor 1 (HSF1-pSer326) Predicts Response to Bortezomib-Containing Chemotherapy in Pediatric AML: A COG Study

Hoff, F. W., van Dijk, A. D., Qiu, Y. H., Ruvolo, P. P., Gerbing, R. B., Leonti, A. R., Jenkins, G. N., Gamis, A. S., Aplenc, R., Kolb, E. A., Alonzo, T., Meshinchi, S., De Bont, E., Bruggeman, S. W., Kornblau, S. M. & Horton, T. M., 25-Feb-2021, In: Blood. 137, 8, p. 1050-1060 11 p.

Research output: Contribution to journal › Article › Academic › peer-review

The H3.3K27M oncohistone affects replication stress outcome and provokes genomic instability in pediatric glioma

Bočkaj, I., Martini, T. E. I., de Camargo Magalhães, E. S., Bakker, P. L., Meeuwsen-de Boer, T. G. J., Armandari, I., Meuleman, S. L., Mondria, M. T., Stok, C., Kok, Y. P., Bakker, B., Wardenaar, R., Seiler, J., Broekhuis, M. J. C., van den Bos, H., Spierings, D. C. J., Ringnalda, F. C. A., Clevers, H., Schüller, U. & van Vugt, M. A. T. M.& 2 others, Foijer, F. & Bruggeman, S. W. M., Nov-2021, In: PLoS genetics. 17, 11, 28 p., 1009868.

Research output: Contribution to journal › Article › Academic › peer-review

Loss of H3K27 Methylation Identifies Poor Outcome in Adult-Onset Acute Myeloid Leukemia

van Dijk, A. D., Hoff, F. W., Qiu, Y., de Bont, E. S., Bruggeman, S. W. M., Horton, T. M. & Kornblau, S. M., 5-Nov-2020, In: Blood. 136, 3 p.

Research output: Contribution to journal › Meeting Abstract › Academic

Loss of H3K27 Methylation Identifies Poor Outcomes in Adult-Onset Acute Lymphoblastic and Myeloid Leukemia

van Dijk, A., Hoff, F., Qiu, Y., Jabbour, E., de Bont, E., Bruggeman, S., Horton, T. & Kornblau, S., Sept-2020, In: Clinical lymphoma myeloma & leukemia. 20, p. S205-S206 2 p.

Research output: Contribution to journal › Meeting Abstract › Academic

Prognostic Significance of FOXO3 in Pediatric Acute Myeloid Leukemia (AML) Patients Treated with Bortezomib Addition to Standard Therapy: Results from a Children's Oncology Group Phase 3 Clinical Trial

van Dijk, A. D., Ruvolo, P. P., Hoff, F. W., Qiu, Y., Gamis, A. S., Aplenc, R., Kolb, A. E., Alonzo, T. A., Gerbing, R. B., de Bont, E. S., Bruggeman, S. W. M., Horton, T. M. & Kornblau, S. M., 13-Nov-2019, In: Blood. 134, 4 p.

Research output: Contribution to journal › Meeting Abstract › Academic

The developmental stage of the medulloblastoma cell-of-origin is maintained in cancer and restricts hedgehog pathway usage and drug sensitivity

Smit, M., Armandari, I., Bockaj, I., Martini, T., Zomerman, W., Siragna, Z., Meeuwsen-de Boer, T., Scherpen, F., Schoots, M., Ritsema, M., den Dunnen, W., Hoving, E., Paridaen, J., de Haan, G., Guryev, V. & Bruggeman, S., Apr-2019, In: Neuro-Oncology. 21, p. 104 1 p.

Research output: Contribution to journal › Meeting Abstract › Academic

All (26) publications

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