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Research interests

Dr. Stephen Peuchen is head of the Research Office of the University Medical Center Groningen (NL), responsible for both research assessments and research funding. He obtained a Ph.D. in Clinical Chemistry from the Department of Pathology of the VCU Medical Center in Richmond VA, U.S.A in 1990. He subsequently moved to the Institute of Neurology of University College London (UCL, U.K.) for a Research Fellow position in the Dept. of Neurochemistry. In his current position he spent more than 10 years on the policy development and implementation of major biobanks (incl. biobank information management systems) in Medicine and remains a national advisor on research policy in biobanking. Dr. Peuchen is a part-time lecturer in Research Methodology in the Master Programme of Transfusion Medicine of the Univ. of Groningen. One of his current interests is the potential application of ‘recommender system’ models to Research Information Systems.

 

Publications

Using Social Network Analysis to Identify Sub-Groups in the Operating Room

Regulation of the ketogenic enzyme mitochondrial 3-hydroxy-3-methylglutaryl-COA synthase in astrocytes and meningeal fibroblasts - Implications in normal brain development and seizure neuropathologies

Distribution of mRNAs Encoding the Peroxisome Proliferator-Activated Receptor α, β, and γ and the Retinoid X Receptor α, β, and γ in Rat Central Nervous System

Energy thresholds in brain mitochondria - Potential involvement in neurodegeneration

Molecular cloning of rat mitochondrial 3-hydroxy-3-methylglutaryl-CoA lyase and detection of the corresponding mRNA and of those encoding the remaining enzymes comprising the ketogenic 3-hydroxy-3-methylglutaryl-CoA cycle in central nervous system of suckling rat

Evaluation of the efficacy of potential therapeutic agents at protecting against nitric oxide synthase-mediated mitochondrial damage in activated astrocytes

Interrelationships between astrocyte function, oxidative stress and antioxidant status within the central nervous system

Ketogenic enzymes in the developing brain

Mitochondria, free radicals & intracellular calcium in cell injury studied in single mammalian cells.

Nitric oxide-mediated mitochondrial damage in the brain: Mechanisms and implications for neurodegenerative diseases

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