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S. Bergink, PhD

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University College Groningen

Telephone:

+31 50 361 6120

+31 50 361 6190 (fax)

Secretariat:

+31 50 361 6111

E-mail:

s.bergink rug.nl

ORCID Research Portal

Research interests

Steven Bergink received his master in molecular biology at the university of Groningen. He obtained his PhD at the ErasmusMC in Rotterdam in the group of Jan Hoeijmakers. He continued with a postdoc at the Max Planck Institute of Biochemistry (Munich, Germany) in the group of Stefan Jentsch. During both his PhD and postdoctoral period he focused on the regulation of DNA repair mechanisms by posttranslational modifications of the ubiquitin family.

Currently he is a group leader at the medical faculty in Groningen. His current research at the Department of Cell biology aims to investigate the intertwinement of DNA repair, protein quality control and neurodegeneration.

Publications

Glioblastoma and its treatment are associated with extensive accelerated brain aging

Ainslie, A. P., Klaver, M., Voshart, D. C., Gerrits, E., den Dunnen, W. F. A., Eggen, B. J. L., Bergink, S. & Barazzuol, L., Mar-2024, In: Aging Cell. 23, 3, 14 p., e14066.

Research output: Contribution to journal › Article › Academic › peer-review

Cooling of Cells and Organs Confers Extensive DNA Strand Breaks Through Oxidative Stress and ATP Depletion

Tolouee Nodolaghi, M., Hendriks, K., Lie, F., Gartzke, L., Goris, M., Hoogstra-Berends, F., Bergink, S. & Henning, R. H., 8-Jul-2022, In: Cell Transplantation. 31, p. 1-12 12 p.

Research output: Contribution to journal › Article › Academic › peer-review

Targeting DNA topoisomerases or checkpoint kinases results in an overload of chaperone systems, triggering aggregation of a metastable subproteome

Huiting, W., Dekker, S. L., van der Lienden, J. C. J., Mergener, R., Musskopf, M. K., Furtado, G. V., Gerrits, E., Coit, D., Oghbaie, M., Di Stefano, L. H., Schepers, H., van Waarde-Verhagen, M. A. W. H., Couzijn, S., Barazzuol, L., LaCava, J., Kampinga, H. H. & Bergink, S., 24-Feb-2022, In: eLife. 11, 29 p., e70726.

Research output: Contribution to journal › Article › Academic › peer-review

The chaperone DNAJB6 surveils FG-nucleoporins and is required for interphase nuclear pore complex biogenesis

Kuiper, E. F. E., Gallardo, P., Bergsma, T., Mari, M., Kolbe Musskopf, M., Kuipers, J., Giepmans, B. N. G., Steen, A., Kampinga, H. H., Veenhoff, L. M. & Bergink, S., Nov-2022, In: Nature Cell Biology. 24, p. 1584-1594 11 p.

Research output: Contribution to journal › Letter › Academic › peer-review

DNAJB chaperones suppress destabilised protein aggregation via a region unique from that used to inhibit amyloidogenesis

McMahon, S., Bergink, S., Kampinga, H. H. & Ecroyd, H., Apr-2021, In: Journal of Cell Science. 134 , 7, 13 p., 255596.

Research output: Contribution to journal › Article › Academic › peer-review

First Virtual International Congress on Cellular and Organismal Stress Responses, November 5-6, 2020

van Oosten-Hawle, P., Bergink, S., Blagg, B., Brodsky, J., Edkins, A., Freeman, B., Genest, O., Hendershot, L., Kampinga, H., Johnson, J., De Maio, A., Masison, D., Morano, K., Multhoff, G., Prodromou, C., Prahlad, V., Scherz-Shouval, R., Zhuravleva, A., Mollapour, M. & Truman, A. W., Mar-2021, In: Cell stress & chaperones. 26, 2, p. 289-295 7 p.

Research output: Contribution to journal › Review article › peer-review

FOXO1 controls protein synthesis and transcript abundance of mutant polyglutamine proteins, preventing protein aggregation

Furtado, G. V., Yang, J., Wu, D., Papagiannopoulos, C. I., Terpstra, H. M., Kuiper, E. F. E., Krauss, S., Zhu, W.-G., Kampinga, H. H. & Bergink, S., 1-Jun-2021, In: Human Molecular Genetics. 30, 11, p. 996-1005 10 p.

Research output: Contribution to journal › Article › Academic › peer-review

Genome instability and loss of protein homeostasis: converging paths to neurodegeneration?

Ainslie, A., Huiting, W., Barazzuol, L. & Bergink, S., 21-Apr-2021, In: Open Biology. 11, 4, p. 1-5 5 p., 200296.

Research output: Contribution to journal › Article › Academic › peer-review

Locked in a vicious cycle: the connection between genomic instability and a loss of protein homeostasis

Huiting, W. & Bergink, S., Feb-2021, In: Genome Instability & Disease. 2, p. 1-23 23 p.

Research output: Contribution to journal › Review article › peer-review

DNAJB6, a Key Factor in Neuronal Sensitivity to Amyloidogenesis

Thiruvalluvan, A., de Mattos, E. P., Brunsting, J. F., Bakels, R., Serlidaki, D., Barazzuol, L., Conforti, P., Fatima, A., Koyuncu, S., Cattaneo, E., Vilchez, D., Bergink, S., Boddeke, E. H. W. G., Copray, S. & Kampinga, H. H., 16-Apr-2020, In: Molecular Cell. 78, 2, p. 346-+ 22 p.

Research output: Contribution to journal › Article › Academic › peer-review

All (32) publications

Press/media

Interview about Ataxias at 'Benefietavond Charity4Brains'

Hipp, M. & Bergink, S.

31/03/2023

Press/Media: Public Engagement Activities › Popular

Charity4brain

Bergink, S.

01/11/2019

Press/Media: Public Engagement Activities › Popular

All (2) press/media

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