M.R. (Matthew) Groves, Prof

Associate Professor

Faculty of Science and Engineering

Telephone:

+31 50 36 33305

E-mail:

m.r.groves rug.nl

ORCID Research Portal

Research interests

Applied Research Activities

Structure-based drug design in human diseases

Basic Research Activities

Structural, biochemical and molecular biology investigation of malarial pathways:

Carbon metabolism in P falciparum

Vitamin biosynthesis in P. falciparum

Method Developments

Crystal identification for structural biology

Biological imaging on free-electron lasers

Publications

Cryo-EM structure of 1-deoxy-D-xylulose 5-phosphate synthase DXPS from Plasmodium falciparum reveals a distinct N-terminal domain

Gawriljuk, V. O., Godoy, A. S., Oerlemans, R., Welker, L. A. T., Hirsch, A. K. H. & Groves, M. R., Dec-2024, In: Nature Communications. 15, 1, 11 p., 6642.

Research output: Contribution to journal › Article › Academic › peer-review

Engineering a Plant Polyketide Synthase for the Biosynthesis of Methylated Flavonoids

Peng, B., Zhang, L., He, S., Oerlemans, R., Quax, W. J., Groves, M. R. & Haslinger, K., 10-Jan-2024, In: Journal of Agricultural and Food Chemistry. 72, 1, p. 529–539 11 p.

Research output: Contribution to journal › Article › Academic › peer-review

Molecular Tumor Board of the University Medical Center Groningen (UMCG-MTB): outcome of patients with rare or complex mutational profiles receiving MTB-advised targeted therapy

de Jager, V. D., Plomp, P., Paats, M. S., van Helvert, S., Elst, A. T., van den Berg, A., Dubbink, H. J., van Geffen, W. H., Zhang, L., Hendriks, L. E. L., Hiltermann, T. J. N., Hiddinga, B. I., Hijmering-Kappelle, L. B. M., Jalving, M., Kluiver, J., Koopman, B., van Kruchten, M., van der Logt, E. M. J., Piet, B. & van Putten, J.& 10 others, Reitsma, B. H., Rutgers, S. R., de Vries, M., Stigt, J. A., Groves, M. R., Timens, W., Willems, S. M., van Kempen, L. C., Schuuring, E. & van der Wekken, A. J., Nov-2024, In: ESMO Open. 9, 11, 12 p., 103966.

Research output: Contribution to journal › Article › Academic › peer-review

Small-Molecule Allosteric Inhibitors of Human Aspartate Transcarbamoylase Suppress Proliferation of Bone Osteosarcoma Epithelial Cells

Wang, C., Zhang, B., Cong, Y., Du, X., Chen, S., Visser, L., Ruiz-Moreno, A., Zhang, L., Reggiori, F., Domling , A. & Groves, M. R., 2-Jul-2024, In: ChemMedChem. 19, 13, 8 p., e202300688.

Research output: Contribution to journal › Article › Academic › peer-review

The prediction of treatment outcome in NSCLC patients harboring an EGFR exon 20 mutation using molecular modeling

Zwierenga, F., Zhang, L., Melcr, J., Schuuring, E., van Veggel, B. A. M. H., de Langen, A. J., Groen, H. J. M., Groves, M. R. & van der Wekken, A. J., Nov-2024, In: Lung Cancer. 197, 8 p., 107973.

Research output: Contribution to journal › Article › Academic › peer-review

A comprehensive overview of the heterogeneity of EGFR exon 20 variants in NSCLC and (pre)clinical activity to currently available treatments

Zwierenga, F., van Veggel, B. A. M. H., van den Berg, A., Groen, H. J. M., Zhang, L., Groves, M. R., Kok, K., Smit, E. F., Hiltermann, T. J. N., de Langen, A. J. & van der Wekken, A. J., Nov-2023, In: CANCER TREATMENT REVIEWS. 120, 10 p., 102628.

Research output: Contribution to journal › Review article › peer-review

Correction: Isolation and molecular characterization of novel glucarpidases: Enzymes to improve the antibody directed enzyme pro-drug therapy for cancer treatment

Rashidi, F. B., Al-Qahtani, A. D., Bashraheel, S. S., Shaabani, S., Groves, M. R., Dömling, A. & Goda, S. K., 21-Nov-2023, In: PLoS ONE. 18, 11, 2 p., e0294885.

Research output: Contribution to journal › Erratum

Determination of Binding Sites on Trastuzumab and Pertuzumab to Selective Affimers Using Hydrogen-Deuterium Exchange Mass Spectrometry

Olaleye, O., Graf, C., Spanov, B., Govorukhina, N., Groves, M. R., van de Merbel, N. C. & Bischoff, R., 5-Apr-2023, In: Journal of the American Society for Mass Spectrometry. 34, 4, p. 775-783 9 p.

Research output: Contribution to journal › Article › Academic › peer-review

Fragment Screening in the Development of a Novel Anti-Malarial

Du, X., Zhang, R. & Groves, M. R., 1-Dec-2023, In: Crystals. 13, 12, 14 p., 1610.

Research output: Contribution to journal › Review article › peer-review

Identification and Characterization of a Small Molecule that Activates Thiosulfate Sulfurtransferase and Stimulates Mitochondrial Respiration

Al-Dahmani, Z. M., Hadian, M., Ruiz-Moreno, A. J., Maria, S.-G. A., Batista, F. A., Zhang, R., Luo, Y., Sadremomtaz, A., van der Straat, R., Spoor, M., Dolga, A. M., Dekker, F. J., S S, A. D., van Goor, H. & Groves, M. R., Nov-2023, In: Protein Science. 32, 11, 18 p., e4794.

Research output: Contribution to journal › Article › Academic › peer-review

All (131) publications

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