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About us Practical matters How to find us M.R. (Matthew) Groves, Prof

M.R. (Matthew) Groves, Prof

Associate Professor

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Faculty of Science and Engineering

Telephone:

+31 50 36 33305

E-mail:

m.r.groves@rug.nl

ORCID Research Portal

Research interests

Applied Research Activities

Structure-based drug design in human diseases

Basic Research Activities

Structural, biochemical and molecular biology investigation of malarial pathways:

Carbon metabolism in P falciparum

Vitamin biosynthesis in P. falciparum

Method Developments

Crystal identification for structural biology

Biological imaging on free-electron lasers

Publications

Apo structure of Mycobacterium tuberculosis 1-deoxy-d-xylulose 5-phosphate synthase DXPS: Dynamics and implications for inhibitor design

Gawriljuk, V. O., Alhayek, A., Hirsch, A. K. H. & Groves, M. R., 2-Feb-2025, In: Biochemical and Biophysical Research Communications. 747, p. 151246 6 p.

Research output: Contribution to journal › Article › Academic › peer-review

Exploring Aspartate Transcarbamoylase: A Promising Broad-Spectrum Target for Drug Development

Chen, S., Mondile, Q., Du, X., Wang, C., Mukim, M., Wrenger, C., Dömling, A. S. S., Tastan Bishop, Ö. & Groves, M. R., 12-Feb-2025, (E-pub ahead of print) In: ChemBioChem. 12 p., e202401009.

Research output: Contribution to journal › Review article › peer-review

New homocysteine consumption assay for high-throughput screening of human Cystathionine-β-synthase

Nakládal, D., Oerlemans, R., Molitorisová, M., Chomaničová, N., Zorkócy, G., Yoseif, C., van der Graaf, A. C., Stuchlík, S., Krenning, G., Groves, M. R., Heeres, A., Levarski, Z., Kyselovič, J., Henning, R. H. & Deelman, L. E., Apr-2025, In: SLAS discovery : advancing life sciences R & D. 32, 9 p., 100234.

Research output: Contribution to journal › Article › Academic › peer-review

Cryo-EM structure of 1-deoxy-D-xylulose 5-phosphate synthase DXPS from Plasmodium falciparum reveals a distinct N-terminal domain

Gawriljuk, V. O., Godoy, A. S., Oerlemans, R., Welker, L. A. T., Hirsch, A. K. H. & Groves, M. R., Dec-2024, In: Nature Communications. 15, 1, 11 p., 6642.

Research output: Contribution to journal › Article › Academic › peer-review

Engineering a Plant Polyketide Synthase for the Biosynthesis of Methylated Flavonoids

Peng, B., Zhang, L., He, S., Oerlemans, R., Quax, W. J., Groves, M. R. & Haslinger, K., 10-Jan-2024, In: Journal of Agricultural and Food Chemistry. 72, 1, p. 529–539 11 p.

Research output: Contribution to journal › Article › Academic › peer-review

Molecular Tumor Board of the University Medical Center Groningen (UMCG-MTB): outcome of patients with rare or complex mutational profiles receiving MTB-advised targeted therapy

de Jager, V. D., Plomp, P., Paats, M. S., van Helvert, S., Elst, A. T., van den Berg, A., Dubbink, H. J., van Geffen, W. H., Zhang, L., Hendriks, L. E. L., Hiltermann, T. J. N., Hiddinga, B. I., Hijmering-Kappelle, L. B. M., Jalving, M., Kluiver, J., Koopman, B., van Kruchten, M., van der Logt, E. M. J., Piet, B. & van Putten, J.& 10 others, Reitsma, B. H., Rutgers, S. R., de Vries, M., Stigt, J. A., Groves, M. R., Timens, W., Willems, S. M., van Kempen, L. C., Schuuring, E. & van der Wekken, A. J., Nov-2024, In: ESMO Open. 9, 11, 12 p., 103966.

Research output: Contribution to journal › Article › Academic › peer-review

Small-Molecule Allosteric Inhibitors of Human Aspartate Transcarbamoylase Suppress Proliferation of Bone Osteosarcoma Epithelial Cells

Wang, C., Zhang, B., Cong, Y., Du, X., Chen, S., Visser, L., Ruiz-Moreno, A., Zhang, L., Reggiori, F., Domling , A. & Groves, M. R., 2-Jul-2024, In: ChemMedChem. 19, 13, 8 p., e202300688.

Research output: Contribution to journal › Article › Academic › peer-review

The prediction of treatment outcome in NSCLC patients harboring an EGFR exon 20 mutation using molecular modeling

Zwierenga, F., Zhang, L., Melcr, J., Schuuring, E., van Veggel, B. A. M. H., de Langen, A. J., Groen, H. J. M., Groves, M. R. & van der Wekken, A. J., Nov-2024, In: Lung Cancer. 197, 8 p., 107973.

Research output: Contribution to journal › Article › Academic › peer-review

A comprehensive overview of the heterogeneity of EGFR exon 20 variants in NSCLC and (pre)clinical activity to currently available treatments

Zwierenga, F., van Veggel, B. A. M. H., van den Berg, A., Groen, H. J. M., Zhang, L., Groves, M. R., Kok, K., Smit, E. F., Hiltermann, T. J. N., de Langen, A. J. & van der Wekken, A. J., Nov-2023, In: CANCER TREATMENT REVIEWS. 120, 10 p., 102628.

Research output: Contribution to journal › Review article › peer-review

Correction: Isolation and molecular characterization of novel glucarpidases: Enzymes to improve the antibody directed enzyme pro-drug therapy for cancer treatment

Rashidi, F. B., Al-Qahtani, A. D., Bashraheel, S. S., Shaabani, S., Groves, M. R., Dömling, A. & Goda, S. K., 21-Nov-2023, In: PLoS ONE. 18, 11, 2 p., e0294885.

Research output: Contribution to journal › Erratum

All (134) publications

Press/media

Startup Protyon krijgt subsidie voor levensverlengende software

Groves, M.

06/07/2023

Press/Media: Expert Comment › Popular

All (1) press/media

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