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About us Practical matters How to find us dr. J.W.C. (Jan-Willem) Alffenaar

University Medical Center Groningen

dr. J.W.C. (Jan-Willem) Alffenaar

hospital pharmacist - clinical pharmacologist

Faculty of Medical Sciences

Telephone:

+31 50 361 4071

+31 50 361 4087 (fax)

E-mail:

j.w.c.alffenaar umcg.nl

ORCID Research Portal

Research interests

During his routine TDM training he developed great interest into infectious diseases in critically ill patients. His research is focussed on the pharmacokinetics and pharmacodynamics of antimicrobial agents, in particular antifungal agents and anti-TB drugs. The aim is to optimize antimicrobial therapy based on PK/PD principles. The overall aim is to find a balance between efficacy and toxicity. Helpful tools are therapeutic drug monitoring, pharmacokinetic modeling, optimal sampling strategies. Also his more analytical oriented reasearch is focused on optimization of treatment by using alternative sampling strategies like dried blood spot sampling and oral fluid as alternative for plasma and serum.

Publications

Analysis of Health-Related Quality of Life and Incurred Costs Among Human Immunodeficiency Virus, Tuberculosis, and Tuberculosis/HIV Coinfected Outpatients in Indonesia

Idrus, L. R., Fitria, N., Purba, F. D., Alffenaar, J. W. C. & Postma, M. J., May-2024, In: Value in Health Regional Issues. 41, p. 32-40 9 p.

Research output: Contribution to journal › Article › Academic › peer-review

A systematic review on the effect of diabetes mellitus on the pharmacokinetics of TB drugs

Cevik, M., Sturdy, A., Maraolo, A. E., Dekkers, B. G. J., Akkerman, O. W., Gillespie, S. H. & Alffenaar, J. W. C., 1-Sept-2024, In: The International Journal of Tuberculosis and Lung Disease. 28, 9, p. 454-460 7 p.

Research output: Contribution to journal › Article › Academic › peer-review

Inflammation altered correlation between CYP2C19 genotype and CYP2C19 activity in patients receiving voriconazole

Klomp, S. D., Veringa, A., Alffenaar, J. W. C., de Boer, M. G. J., Span, L. F. R., Guchelaar, H. J. & Swen, J. J., Jul-2024, In: Clinical and translational science. 17, 7, 10 p., e13887.

Research output: Contribution to journal › Article › Academic › peer-review

Ten-year results of an international external quality control programme for measurement of anti-tuberculosis drug concentrations

Stemkens, R., Mouhdad, C., Franssen, E. J. F., Touw, D., Alffenaar, J.-W., Te Brake, L. H. M., Sturkenboom, M. G. G. & Aarnoutse, R. E., Jun-2024, In: The Journal of antimicrobial chemotherapy. 79, 6, p. 1346–1352 7 p.

Research output: Contribution to journal › Article › Academic › peer-review

Tuberculosis impacts multiple aspects in quality of life in a Romanian cohort of drug-susceptible and drug resistant patients: A patient-reported outcome measures study

Margineanu, I., Butnaru, T., Lam, M., Baiceanu, D., Dragomir, R., Arbore, A. S., Mahler, B., Munteanu, I., Mihaltan, F., Akkerman, O., Alffenaar, J.-W. & Stienstra, Y., Jul-2024, In: Tropical Medicine & International Health. 29, 7, p. 584-593 10 p.

Research output: Contribution to journal › Article › Academic › peer-review

Bedaquiline exposure in people with drug-resistant TB treated for diabetes: analysis of two phase 2 trials

Bolhuis, M. S., Akkerman, O. W., Sturkenboom, M. G. G., van Boven, J. F. M., Alffenaar, J.-W. C. & Stevens, J., 1-Apr-2023, In: The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease. 27, 4, p. 335-337 3 p.

Research output: Contribution to journal › Article › Academic › peer-review

Clinical standards for the management of adverse effects during treatment for TB

Singh, K. P., Carvalho, A. C. C., Centis, R., D'Ambrosio, L., Migliori, G. B., Mpagama, S. G., Nguyen, B. C., Aarnoutse, R. E., Aleksa, A., van Altena, R., Bhavani, P. K., Bolhuis, M. S., Borisov, S., van 't Boveneind-Vrubleuskaya, N., Bruchfeld, J., Caminero, J. A., Carvalho, I., Cho, J. G., Davies Forsman, L. & Dedicoat, M.& 45 others, Dheda, K., Dooley, K., Furin, J., García-García, J. M., Garcia-Prats, A., Hesseling, A. C., Heysell, S. K., Hu, Y., Kim, H. Y., Manga, S., Marais, B. J., Margineanu, I., Märtson, A.-G., Munoz Torrico, M., Nataprawira, H. M., Nunes, E., Ong, C. W. M., Otto-Knapp, R., Palmero, D. J., Peloquin, C. A., Rendon, A., Rossato Silva, D., Ruslami, R., Saktiawati, A. M. I., Santoso, P., Schaaf, H. S., Seaworth, B., Simonsson, U. S. H., Singla, R., Skrahina, A., Solovic, I., Srivastava, S., Stocker, S. L., Sturkenboom, M. G. G., Svensson, E. M., Tadolini, M., Thomas, T. A., Tiberi, S., Trubiano, J., Udwadia, Z. F., Verhage, A. R., Vu, D. H., Akkerman, O. W., Alffenaar, J. W. C. & Denholm, J. T., 1-Jul-2023, In: The International Journal of Tuberculosis and Lung Disease. 27, 7, p. 506-519 14 p.

Research output: Contribution to journal › Article › Academic › peer-review

Dried Blood Spot Sampling to Assess Rifampicin Exposure and Treatment Outcomes among Native and Non-Native Tuberculosis Patients in Paraguay: An Exploratory Study

Ghimire, S., Molinas, G., Battaglia, A., Martinez, N., Gómez Paciello, L., Aguirre, S., Alffenaar, J. W. C., Sturkenboom, M. G. G. & Magis-Escurra, C., Apr-2023, In: Pharmaceutics. 15, 4, 1089.

Research output: Contribution to journal › Article › Academic › peer-review

Exposure of anti-infective drugs and the dynamic changes of the gut microbiota during gastrointestinal mucositis in autologous stem cell transplant patients: a pilot study

Märtson, A. G., da Silva Ferreira, A. R., Veringa, A., Liu, L., Wardill, H. R., Junier, L. A. T., van der Werf, T. S., Harmsen, H. J. M., Sturkenboom, M. G. G., Span, L. F., Tissing, W. J. E. & Alffenaar, J. W. C., Feb-2023, In: Annals of Hematology. 102, 2, p. 421-427 7 p.

Research output: Contribution to journal › Article › Academic › peer-review

Global estimates and determinants of antituberculosis drug pharmacokinetics in children and adolescents: a systematic review and individual patient data meta-analysis

Global Collaborative Group for Meta-Analysis of Paediatric Individual Patient Data in Pharmacokinetics of Anti-TB Drugs, Gafar, F., Wasmann, R. E., McIlleron, H. M., Aarnoutse, R. E., Schaaf, H. S., Marais, B. J., Agarwal, D., Antwi, S., Bang, N. D., Bekker, A., Bell, D. J., Chabala, C., Choo, L., Davies, G. R., Day, J. N., Dayal, R., Denti, P., Donald, P. R. & Engidawork, E.& 31 others, Garcia-Prats, A. J., Gibb, D., Graham, S. M., Hesseling, A. C., Heysell, S. K., Idris, M. I., Kabra, S. K., Kinikar, A., Hemanth Kumar, A. K., Kwara, A., Lodha, R., Magis-Escurra, C., Martinez, N., Mathew, B. S., Mave, V., Mduma, E., Mlotha-Mitole, R., Mpagama, S. G., Mukherjee, A., Nataprawira, H. M., Peloquin, C. A., Pouplin, T., Ramachandran, G., Ranjalkar, J., Roy, V., Sturkenboom, M. G. G., Thee, S., Touw, D. J., Taxis, K., Stevens, J. & Alffenaar, J.-W. C., 2023, In: European Respiratory Journal. 61, 23 p., 2201596.

Research output: Contribution to journal › Review article › peer-review

All (338) publications

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