J.P. (John) LaCava

Telephone:

E-mail:

j.p.lacava umcg.nl

Research interests

For the latest information please consult the resources below.
Personal Website - http://www.macromolecule.fun
Twitter - https://twitter.com/macro_momo
ORCID - https://orcid.org/0000-0002-6307-7713

Others
http://copurification.org/
http://www.ncdir.org/

Publications

CCDC88B interacts with RASAL3 and ARHGEF2 and regulates dendritic cell function in neuroinflammation and colitis

Olivier, J. F., Langlais, D., Jeyakumar, T., Polyak, M. J., Galarneau, L., Cayrol, R., Jiang, H., Molloy, K. R., Xu, G., Suzuki, H., LaCava, J., Gros, P. & Fodil, N., 10-Jan-2024, In: Communications biology. 7, 19 p., 77.

Research output: Contribution to journal › Article › Academic › peer-review

Multiparameter screen optimizes immunoprecipitation

Xie, S., Saba, L., Jiang, H., Bringas, O. R., Oghbaie, M., Stefano, L. D., Sherman, V. & LaCava, J., Apr-2024, In: Biotechniques. 76, 4, p. 145-152 8 p.

Research output: Contribution to journal › Article › Academic › peer-review

Structures, functions and adaptations of the human LINE-1 ORF2 protein

Baldwin, E. T., van Eeuwen, T., Hoyos, D., Zalevsky, A., Tchesnokov, E. P., Sánchez, R., Miller, B. D., Di Stefano, L. H., Ruiz, F. X., Hancock, M., Işik, E., Mendez-Dorantes, C., Walpole, T., Nichols, C., Wan, P., Riento, K., Halls-Kass, R., Augustin, M., Lammens, A. & Jestel, A.& 25 others, Upla, P., Xibinaku, K., Congreve, S., Hennink, M., Rogala, K. B., Schneider, A. M., Fairman, J. E., Christensen, S. M., Desrosiers, B., Bisacchi, G. S., Saunders, O. L., Hafeez, N., Miao, W., Kapeller, R., Zaller, D. M., Sali, A., Weichenrieder, O., Burns, K. H., Götte, M., Rout, M. P., Arnold, E., Greenbaum, B. D., Romero, D. L., LaCava, J. & Taylor, M. S., 1-Feb-2024, In: Nature. 626, p. 194–206 13 p.

Research output: Contribution to journal › Article › Academic › peer-review

Subcellular location of L1 retrotransposon-encoded ORF1p, reverse transcription products, and DNA sensors in lupus granulocytes

Moadab, F., Sohrabi, S., Wang, X., Najjar, R., Wolters, J. C., Jiang, H., Miao, W., Romero, D., Zaller, D. M., Tran, M., Bays, A., Taylor, M. S., Kapeller, R., LaCava, J. & Mustelin, T., 27-Jun-2024, In: Mobile dna. 15, 14 p., 14.

Research output: Contribution to journal › Article › Academic › peer-review

Affinity-Based Interactome Analysis of Endogenous LINE-1 Macromolecules

Di Stefano, L. H., Saba, L. J., Oghbaie, M., Jiang, H., McKerrow, W., Benitez-Guijarro, M., Taylor, M. S. & LaCava, J., 2023, Methods in Molecular Biology. Humana Press, p. 215-256 42 p. (Methods in Molecular Biology; vol. 2607).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

Cancer cells co-evolve with retrotransposons to mitigate viral mimicry

Sun, S., Hong, J., You, E., Tsanov, K. M., Chacon-Barahona, J., Gioacchino, A. D., Hoyos, D., Li, H., Jiang, H., Ly, H., Marhon, S., Murali, R., Chanda, P., Karacay, A., Vabret, N., De Carvalho, D. D., LaCava, J., Lowe, S. W., Ting, D. T. & Iacobuzio-Donahue, C. A.& 2 others, Solovyov, A. & Greenbaum, B. D., 20-May-2023, BioRxiv, (bioRxiv).

Research output: Working paper › Preprint › Academic

Consequences of a telomerase-related fitness defect and chromosome substitution technology in yeast synIX strains

The Build-A-Genome Class, McCulloch, L. H., Sambasivam, V., Hughes, A. L., Annaluru, N., Ramalingam, S., Fanfani, V., Lobzaev, E., Mitchell, L. A., Cai, J., Jiang, H., LaCava, J., Taylor, M. S., Bishai, W. R., Stracquadanio, G., Steinmetz, L. M. & Bader, J. S., 8-Nov-2023, In: Cell Genomics. 3, 11, 15 p., 100419.

Research output: Contribution to journal › Article › Academic › peer-review

Expression of L1 retrotransposons in granulocytes from patients with active systemic lupus erythematosus

Ukadike, K. C., Najjar, R., Ni, K., Laine, A., Wang, X., Bays, A., Taylor, M. S., LaCava, J. & Mustelin, T., 10-May-2023, In: Mobile dna. 14, 15 p., 5.

Research output: Contribution to journal › Article › Academic › peer-review

MsPHep: An online application for low molecular weight heparin rapid characterization based on liquid chromatography-tandem mass spectrometry

Xie, S., Bu, C., LaCava, J. & Chi, L., 30-Aug-2023, In: Journal of Chromatography A. 1705, 9 p., 464179.

Research output: Contribution to journal › Article › Academic › peer-review

Multiple RNA-binding proteins associated with long interspersed element-1 encoded ORF1p are targeted by the autoimmune response in systemic lupus erythematosus

Ukadike, K. C., Colyer, A. N., Duvvuri, B., Bengtsson, A. A., Taylor, M. S., LaCava, J., Lood, C. & Mustelin, T., 2023, In: Journal of Cellular and Molecular Immunology. 2, 1, p. 35-44 10 p.

Research output: Contribution to journal › Article › Academic › peer-review