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About us Practical matters How to find us dr. J.L. (Joost) Kluiver

Research interests

Over the last decade it has become clear that non-coding RNAs are important players in virtually all physiological processes. Deregulation of non-coding RNAs contributes to diseases including cancer.

In our studies we focus on understanding how small and long non-coding RNAs contribute to the pathogenesis of B-cell lymphoma. These include studies on MYC –regulated miRNAs and lncRNAs, miRNA-lncRNA interactions and the role of lncRNAs in epigenetics.

 

Keywords: B-cell lymphoma, non-coding RNAs, microRNA, lncRNAs

Publications

An Unexpected Finding of a PTPN11 Germline Mutation in a Patient With a Melanocytic Lesion With a Somatic MAP2K1 Mutation. Coincidence or Not?

Circular ZDHHC11 supports Burkitt lymphoma growth independent of its miR-150 binding capacity

Core regions in immunoglobulin heavy chain enhancers essential for survival of non-Hodgkin lymphoma cells are identified by a CRISPR interference screen

Detection of circulating tumor DNA in plasma of patients with primary CNS lymphoma by digital droplet PCR

Inhibition of the glutamate-cysteine ligase catalytic subunit with buthionine sulfoximine enhances the cytotoxic effect of doxorubicin and cyclophosphamide in Burkitt lymphoma cells

Molecular Tumor Board of the University Medical Center Groningen (UMCG-MTB): outcome of patients with rare or complex mutational profiles receiving MTB-advised targeted therapy

NEAT1 and CHROMR lncRNAs: a promising diagnostic tool for diffuse large B-cell lymphoma especially in elderly patients

Pinpointing Functionally Relevant miRNAs in Classical Hodgkin Lymphoma Pathogenesis

A population-based study of transformed marginal zone lymphoma: identifying outcome-related characteristics

CRISPR/Cas9 screen for genome-wide interrogation of essential MYC-bound E-boxes in cancer cells

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Press/media

Receiving funding from Lymph&Co