dr. J. (Jaap) Broos

Associate professor

Faculty of Science and Engineering

Telephone:

+31 50 36 34277

E-mail:

j.broos rug.nl

Homepage Research Portal

Publications

Altering Specificity and Enhancing Stability of the Antimicrobial Peptides Nisin and Rombocin through Dehydrated Amino Acid Residue Engineering

Guo, L., Stoffels, K., Broos, J. & Kuipers, O. P., Apr-2024, In: Peptides. 174, 26 p., 171152.

Research output: Contribution to journal › Article › Academic › peer-review

An Engineered Nisin Analogue with a Hydrophobic Moiety Attached at Position 17 Selectively Inhibits Enterococcus faecium Strains.

Guo, L., Kuipers, O. P. & Broos, J., 20-Sept-2024, In: ACS chemical biology. 19, 9, p. 2023-2031 9 p., 4c00337.

Research output: Contribution to journal › Article › Academic › peer-review

Engineering hybrid lantibiotics yields the highly stable and bacteriocidal peptide cerocin V

Guo, L., Stoffels, K., Broos, J. & Kuipers, O. P., May-2024, In: Microbiological Research. 282, 11 p., 127640.

Research output: Contribution to journal › Article › Academic › peer-review

Facile Halogenation of Antimicrobial Peptides As Demonstrated by Producing Bromotryptophan-Labeled Nisin Variants with Enhanced Antimicrobial Activity

Guo, L., Kuipers, O. P. & Broos, J., 28-Jun-2024, In: Journal of Natural Products. 87, 6, p. 1548-1555 8 p.

Research output: Contribution to journal › Article › Academic › peer-review

Rombocin, a Short Stable Natural Nisin Variant, Displays Selective Antimicrobial Activity against Listeria monocytogenes and Employs a Dual Mode of Action to Kill Target Bacterial Strains.

Guo, L., Wambui, J., Wang, C., Broos, J., Stephan, R. & Kuipers, O. P., 19-Jan-2024, In: ACS Synthetic Biology. 13, 1, p. 370–383 15 p., 3c00612.

Research output: Contribution to journal › Article › Academic › peer-review

Cesin, a short natural variant of nisin, displays potent antimicrobial activity against major pathogens despite lacking two C-terminal macrocycles

Guo, L., Wambui, J., Wang, C., Muchaamba, F., Fernandez-Cantos, M. V., Broos, J., Tasara, T., Kuipers, O. P. & Stephan, R., Oct-2023, In: Microbiology Spectrum. 11, 5, 21 p., e0531922.

Research output: Contribution to journal › Article › Academic › peer-review

Lipidated variants of the antimicrobial peptide nisin produced via incorporation of methionine analogs for click chemistry show improved bioactivity

Guo, L., Wang, C., Broos, J. & Kuipers, O. P., Jul-2023, In: The Journal of Biological Chemistry. 229, 7, 12 p., 104845.

Research output: Contribution to journal › Article › Academic › peer-review

All (78) publications

View full research profile

dr. J. (Jaap) Broos

Publications

Altering Specificity and Enhancing Stability of the Antimicrobial Peptides Nisin and Rombocin through Dehydrated Amino Acid Residue Engineering

An Engineered Nisin Analogue with a Hydrophobic Moiety Attached at Position 17 Selectively Inhibits Enterococcus faecium Strains.

Engineering hybrid lantibiotics yields the highly stable and bacteriocidal peptide cerocin V

Facile Halogenation of Antimicrobial Peptides As Demonstrated by Producing Bromotryptophan-Labeled Nisin Variants with Enhanced Antimicrobial Activity

Rombocin, a Short Stable Natural Nisin Variant, Displays Selective Antimicrobial Activity against Listeria monocytogenes and Employs a Dual Mode of Action to Kill Target Bacterial Strains.

Cesin, a short natural variant of nisin, displays potent antimicrobial activity against major pathogens despite lacking two C-terminal macrocycles

Lipidated variants of the antimicrobial peptide nisin produced via incorporation of methionine analogs for click chemistry show improved bioactivity

Probing the Conformational States of Thimet Oligopeptidase in Solution

The Role of Tryptophan in π Interactions in Proteins: An Experimental Approach

Cyano-tryptophans as dual infrared and fluorescence spectroscopic labels to assess structural dynamics in proteins