dr. I.R. Holtman

Faculty of Medical Sciences

Telephone:

E-mail:

i.r.holtman umcg.nl

ORCID Research Portal

Publications

Disentangling the heterogeneity of multiple sclerosis through identification of independent neuropathological dimensions

de Boer, A., van den Bosch, A. M. R., Mekkes, N. J., Fransen, N. L., Dagkesamanskaia, E., Hoekstra, E., Hamann, J., Smolders, J., Huitinga, I. & Holtman, I. R., 21-May-2024, In: Acta Neuropathologica. 147, 21 p., 90.

Research output: Contribution to journal › Article › Academic › peer-review

Identification of clinical disease trajectories in neurodegenerative disorders with natural language processing

Mekkes, N. J., Groot, M., Hoekstra, E., de Boer, A., Dagkesamanskaia, E., Bouwman, S., Wehrens, S. M. T., Herbert, M. K., Wever, D. D., Rozemuller, A., Eggen, B. J. L., Huitinga, I. & Holtman, I. R., Apr-2024, In: Nature Medicine. 30, 4, p. 1143-1153 11 p.

Research output: Contribution to journal › Article › Academic › peer-review

Interpretation of Neurodegenerative GWAS Risk Alleles in Microglia and their Interplay with Other Cell Types

Holtman, I. R., Glass, C. K. & Nott, A., 2024, Microglia. Springer Nature, Vol. 37. p. 531-544 14 p. (Advances in neurobiology).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

Radiotherapy induces persistent innate immune reprogramming of microglia into a primed state

Voshart, D. C., Oshima, T., Jiang, Y., van der Linden, G. P., Ainslie, A. P., Reali Nazario, L., van Buuren-Broek, F., Scholma, A. C., van Weering, H. R. J., Brouwer, N., Sewdihal, J., Brouwer, U., Coppes, R. P., Holtman, I. R., Eggen, B. J. L., Kooistra, S. M. & Barazzuol, L., 27-Feb-2024, 2 ed. 17 p. (Cell reports)

Research output: Book/Report › Report › Academic › peer-review

Spatial mapping of Alzheimer’s disease across genetic subtypes: Spatial transcriptomics

Nott, A. & Holtman, I. R., Dec-2024, In: Nature genetics. 56, 12, p. 2592-2593 2 p., 4710.

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

Genetic insights into immune mechanisms of Alzheimer's and Parkinson's disease

Nott, A. & Holtman, I. R., 8-Jun-2023, In: Frontiers in Immunology. 14, 15 p., 1168539.

Research output: Contribution to journal › Review article › peer-review

Identification of neuropathology-based subgroups in multiple sclerosis using a data-driven approach

de Boer, A., van den Bosch, A. M. R., Mekkes, N., Fransen, N., Hoekstra, E., Smolders, J., Hamann, J., Huitinga, I. & Holtman, I. R., 16-May-2023, MedRxiv, 19 p.

Research output: Working paper › Preprint › Academic

SALL1 enforces microglia-specific DNA binding and function of SMADs to establish microglia identity

Fixsen, B. R., Han, C. Z., Zhou, Y., Spann, N. J., Saisan, P., Shen, Z., Balak, C., Sakai, M., Cobo, I., Holtman, I. R., Warden, A. S., Ramirez, G., Collier, J. G., Pasillas, M. P., Yu, M., Hu, R., Li, B., Belhocine, S., Gosselin, D. & Coufal, N. G.& 2 others, Ren, B. & Glass, C. K., Jul-2023, In: Nature Immunology. 24, 7, p. 1188-1199 12 p.

Research output: Contribution to journal › Article › Academic › peer-review

The Netherlands Neurogenetics Database (NND)

Holtman, I. R. (Developer), Swertz, M. A. (Developer), Rozenmuller, A. (Developer), Hamann, J. (Developer), Boddeke, E. W. G. M. (Developer), Eggen, B. (Developer) & Huitinga, I. (Developer), 1-Sept-2023

Research output: Non-textual form › Data set/Database › Academic

Dissecting the limited genetic overlap of Parkinson's and Alzheimer's disease

Int Parkinson's Dis Genomics Conso, Andersen, M. S., Tan, M., Holtman, I. R., Hardy, J. & Pihlstrom, L., 2022, In: Annals of Clinical and Translational Neurology. 9, 8, p. 1289-1295 7 p.

Research output: Contribution to journal › Article › Academic › peer-review