dr. I.H. Jonkers

Faculty of Medical Sciences

Telephone:

+31 50 361 7100

E-mail:

i.h.jonkers umcg.nl

Research Portal

Publications

Human organoids and organ-on-chips in coeliac disease research

Simpson, H. L., Smits, E., Moerkens, R., Wijmenga, C., Mooiweer, J., Jonkers, I. H. & Withoff, S., Feb-2025, In: Trends in Molecular Medicine. 31, 2, p. 117-137 21 p.

Research output: Contribution to journal › Review article › peer-review

Shared Genetics in Celiac Disease and Inflammatory Bowel Disease Specify a Greater Role for Intestinal Epithelial Cells

Ribeiro, N. V., Anwar, S., Withoff, S. & Jonkers, I. H., Apr-2025, In: International Journal of Molecular Sciences. 26, 7, 2982.

Research output: Contribution to journal › Review article › peer-review

An iPSC-derived small intestine-on-chip with self-organizing epithelial, mesenchymal, and neural cells

Moerkens, R., Mooiweer, J., Ramírez-Sánchez, A. D., Oelen, R., Franke, L., Wijmenga, C., Barrett, R. J., Jonkers, I. H. & Withoff, S., 23-Jul-2024, In: Cell reports. 43, 7, 26 p., 114247.

Research output: Contribution to journal › Article › Academic › peer-review

Coeliac disease in the Trøndelag Health Study (HUNT), Norway, a population-based cohort of coeliac disease patients

Lukina, P., Andersen, I. L., Eggen, P. T., Mjønes, P. G., Rønne, E., Bolstad, N., Klaasen, R. A., Warren, J. D., Iversen, R., Hveem, K., Bernklev, T., Jelsness-Jørgensen, L. P., Pedersen, L., Jonkers, I., Lagergren, P., Sollid, L. M., Lundin, K. & Ness-Jensen, E., 9-Jan-2024, In: BMJ Open. 14, 7 p., e077131.

Research output: Contribution to journal › Article › Academic › peer-review

Gene expression and eQTL analysis reflect the heterogeneity in the inflammatory status of the duodenal epithelial lining in coeliac disease

Ramírez-Sánchez, A., Zühlke, S., Aguirre-Gamboa, R., Vochteloo, M., Franke, L., Lundin, K. E. A., Withoff, S. & Jonkers, I. H., 4-Mar-2024, BioRxiv.

Research output: Working paper › Preprint › Academic

Genetic mapping across autoimmune diseases reveals shared associations and mechanisms

International Multiple Sclerosis Genetics Consortium, Lincoln, M. R., Connally, N., Axisa, P.-P., Gasperi, C., Mitrovic, M., van Heel, D., Wijmenga, C., Withoff, S., Jonkers, I. H., Padyukov, L., Rich, S. S., Graham, R. R., Gaffney, P. M., Langefeld, C. D., Vyse, T. J., Hafler, D. A., Chun, S., Sunyaev, S. R. & Cotsapas, C., May-2024, In: Nature genetics. 56, 5, p. 838-845 8 p.

Research output: Contribution to journal › Article › Academic › peer-review

Genome-wide association study identifies novel risk variants for celiac disease in the 5p15.33 locus: insights from a population-based screening of adults, the HUNT

Alam, M. S., Thomas, L. F., Brumpton, B., Hveem, K., Lundin, K. E. A., Withoff, S., Jonkers, I. H., Sollid, L. M., Hjort, R. & Ness-Jensen, E., 12-Dec-2024, MedRxiv.

Research output: Working paper › Preprint › Academic

High-resolution analysis of the treated coeliac disease microbiome reveals strain-level variation

Slager, J., Simpson, H. L., Gacesa, R., Chen, L., Tan, I. L., Gelderloos, J., Maatman, A., Wijmenga, C., Zhernakova, A., Fu, J., Weersma, R. K., Gonera, G., Jonkers, I. H. & Withoff, S., 21-Dec-2024, BioRxiv.

Research output: Working paper › Preprint › Academic

Identification of rare disease genes as drivers of common diseases through tissue-specific gene regulatory networks

Bakker, O. B., Claringbould, A., Westra, H. J., Wiersma, H., Boulogne, F., Võsa, U., Urzúa-Traslaviña, C. G., Mulcahy Symmons, S., Zidan, M. M. M., Sadler, M. C., Kutalik, Z., Jonkers, I. H., Franke, L. & Deelen, P., Dec-2024, In: Scientific Reports. 14, 13 p., 30206.

Research output: Contribution to journal › Article › Academic › peer-review

Intestine-on-chip enhances nutrient and drug metabolism and maturation of iPSC-derived intestinal epithelial cells relative to organoids and Transwells

Moerkens, R., Mooiweer, J., Smits, E., Berg, M., Ramírez-Sánchez, A. D., Modderman, R., Puschhof, J., Pleguezuelos-Manzano, C., Barrett, R. J., Wijmenga, C., Jonkers, I. H. & Withoff, S., 1-Jul-2024, BioRxiv.

Research output: Working paper › Preprint › Academic