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I.B. Hovens

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Faculty of Behavioural and Social Sciences

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i.b.hovens rug.nl

Research Portal

Research interests

An estimated ten percent of the elderly surgical patients develops long-lasting postoperative cognitive dysfunction (POCD) , with serious consequences for their quality of life, dependency on social services and prognosis. In patientstudies and experimental studies in an animal model we investigate the underlying mechanisms, in particular the involvement of neuroinflammation, of surgery-induced impairment of specific brain regions and cognitive functions. Additionaly, we research potential (preventive) therapies for POCD.

Publications

Acute pre-operative ibuprofen improves cognition in a rat model for postoperative cognitive dysfunction

Oberman, K., Hovens, I., de Haan, J., Falcao-Salles, J., van Leeuwen, B. & Schoemaker, R., 2021, In: Journal of neuroinflammation. 18, 1, p. 1-13 13 p., 156.

Research output: Contribution to journal › Article › Academic › peer-review

Correlations of blood and brain biochemistry in phenylketonuria: Results from the Pah-enu2 PKU mouse

Dijkstra, A. M., van Vliet, N., van Vliet, D., Romani, C., Huijbregts, S. C. J., van der Goot, E., Hovens, I. B., van der Zee, E. A., Kema, I. P., Heiner-Fokkema, M. R. & van Spronsen, F. J., Nov-2021, In: Molecular Genetics and Metabolism. 134, 3, p. 250-256 7 p.

Research output: Contribution to journal › Article › Academic › peer-review

Enteral enriched nutrition to prevent cognitive dysfunction after surgery: A study in rats

Hovens, I. B., van Leeuwen, B. L., Falcao-Salles, J., de Haan, J. J. & Schoemaker, R. G., Oct-2021, In: Brain, behavior, & immunity - health. 16, 100305.

Research output: Contribution to journal › Article › Academic › peer-review

Neutrophil gelatinase-associated lipocalin and microglial activity are associated with distinct postoperative behavioral changes in rats

Gouweleeuw, L., Hovens, I. B., van Leeuwen, B. L. & Schoemaker, R. G., 15-Feb-2017, In: Behavioral Brain Research. 319, p. 104-109 6 p.

Research output: Contribution to journal › Article › Academic › peer-review

Differences in the association between behavior and neutrophil gelatinase-associated lipocalin in male and female rats after coronary artery ligation

Gouweleeuw, L., Hovens, I. B., Liu, H., Naude, P. J. W. & Schoemaker, R., 1-Sept-2016, In: Physiology & Behavior. 163, p. 7-16 10 p.

Research output: Contribution to journal › Article › Academic › peer-review

Postoperative cognitive dysfunction and neuroinflammation: Cardiac surgery and abdominal surgery are not the same

Hovens, I. B., van Leeuwen, B. L., Mariani, M. A., Kraneveld, A. D. & Schoemaker, R. G., May-2016, In: Brain behavior and immunity. 54, p. 178-193 16 p.

Research output: Contribution to journal › Article › Academic › peer-review

Characterizing postoperative cognitive dysfunction in the elderly

Hovens, I. B., 2015, [Groningen]: University of Groningen. 259 p.

Research output: Thesis › Thesis fully internal (DIV)

Postoperative cognitive dysfunction and microglial activation in associated brain regions in old rats

Hovens, I. B., van Leeuwen, B. L., Nyakas, C., Heineman, E., van der Zee, E. A. & Schoemaker, R. G., Feb-2015, In: Neurobiology of Learning and Memory. 118, p. 74-79 6 p.

Research output: Contribution to journal › Article › Academic › peer-review

Prior infection exacerbates postoperative cognitive dysfunction in aged rats

Hovens, I. B., van Leeuwen, B. L., Nyakas, C., Heineman, E., van der Zee, E. A. & Schoemaker, R. G., 15-Jul-2015, In: American Journal of Physiology - Regulatory, Integrative and Comparative Physiology. 309, 2, p. R148-R159 12 p.

Research output: Contribution to journal › Article › Academic › peer-review

A novel method for evaluating microglial activation using ionized calcium-binding adaptor protein-1 staining: cell body to cell size ratio

Hovens, I., Nyakas, C. & Schoemaker, R., 2014, In: Neuroimmunology and Neuroinflammation. p. 82-88 7 p.

Research output: Contribution to journal › Article › Academic › peer-review

All (16) publications

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