H.J. (Henk) Busscher
CONDENSED CURRICULUM VITAE
of : HENDRIK JAN BUSSCHER
born : 24‑10‑1955
in : GRONINGEN, THE NETHERLANDS
address, office : Department of Biomaterials and Biomedical Technology
University Medical Center and University of Groningen
Antonius Deusinglaan 1
9713 AV GRONINGEN, THE NETHERLANDS
http://www.rug.nl/research/biomaterials/
e-mail : h.j.busscher@umcg.nl
Research interests:
- Physico-chemistry of the interactions of biological components
(proteins, cells, microorganisms) with materials, including
biomaterials and dental surfaces and biofilm community aspects.
- Prevention of biomaterial-associated infections through surface modification, as well as improved methods for diagnosis of biomaterial-associated infection.
- Development of pathogenic biofilms on biomaterial surfaces and influences of antibiotics and probiotics.
- Characterization of biomaterial surfaces and coatings through physico-chemical techniques and mechanisms of microbial adhesion, required for the development of necessary therapeutic and prophylactic methods for biomaterials-associated infection.
- Design of animal studies for evaluating anti-infection strategies replacing clinical studies, and design of in vitro studies replacing animal experiments for evaluating anti-infection strategies.
- Prevention of infection of tissue-engineered constructs.
-Biomaterials implant retrieval for microbiological and surface analyses in orthopedics, ophthalmology, plastic surgery and otorhinolaryngology.
Current positions :
1. Researcher at the Department of Biomaterials and Biomedical technology, University Medical Center and University of Groningen (appointed for 20%).
2. Director-owner of a consulting company: Scientific and Applied Surface Advice.
3. Editor: Colloids and Surfaces B: Biointerfaces
Conferences, memberships, numbers of papers and patents, PhD theses supervised:
- Conferences and Symposia Organized : 14
- Memberships of Scientific Organizations : 3
- Editorial board Memberships : 3
- Books and Journals Edited : 10
- Patents : 6
- Theses supervised : >120
- Full papers, including book chapters : >666
Web-of-Science Summary (Janyary 2024):
Number of articles, short notes, reviews and
proceeding papers in English >666
Total number of citations 35474
Average number of citations per paper 53.26
H-factor 92
Disclaimer:
-
I’m the director-owner of a consulting company “Scientific and Applied Surface Advice”. SASA BV has been consulting for or is currently consulting for amongst others: ATOS Medical, Bausch & Lomb, Braun-Oral B, Colgate-Palmolive (pending), DePuy Orthopeadics, GABA International, Henkel AG, Philips Sonicare, Procter & Gamble, Straumann International, Wrigley.
-
I have permission for my activities within SASA BV from the University of Groningen/ University Medical Center Groningen.
-
I, nor SASA BV, have any financial interests in the companies that SASA BV consults for.
-
My academic work has been directly funded by DSM, Ethicon, FCDF, Philips, SASA BV, Zorginnovatie BV (pending).
-
My academic work has furthermore been funded by IOP milieutechnologie / Zware Metalen, Senter, STW grants 07109, 07844, Eureka grants 72310, 2614, BMM-grant P4.01 NANTICO (BMM is a Dutch public-private partnership co-funded by the Dutch Ministry of Economic Affairs) and FP-7 project FORMAMP.
My academic work may have been directly or indirectly, but always unintentionally, influenced by (a) the companies that SASA BV has consulted for, (b) industrial partners that have directly funded my academic work or (c) industrial partners in the public-private partnerships related to the grants that fund my academic work. However, all opinions and assertions contained in my academic work are mine, i.e. those of my co-authors and are not construed as necessarily representing views of the funding organizations.
Ten land-mark papers over the past five years (per July 2021):
Title |
Journal |
Year |
Volume |
Beginning Page |
Ending page |
Liposomes with Water as a pH-Responsive Functionality for Targeting of Acidic Tumor and Infection Sites |
ANGEWANDTE CHEMIE INT. EDITION |
2021 |
60 |
2 |
8 |
Clearance of ESKAPE Pathogens from Blood Using Bacterially Activated Macrophage Membrane-Coated Silicon Nanowires |
ADVANCED FUNCTIONAL MATERIALS |
2021 |
31 |
|
|
Accepting higher morbidity in exchange for sacrificing fewer animals in studies developing novel infection-control strategies |
BIOMATERIALS |
2020 |
232 |
|
|
Self-targeting, zwitterionic micellar dispersants enhance antibiotic killing of infectious biofilms-An intravital imaging study in mice |
SCIENCE ADVANCES |
2020 |
6 |
|
|
Coating of a Novel Antimicrobial Nanoparticle with a Macrophage Membrane for the Selective Entry into Infected Macrophages and Killing of Intracellular Staphylococci |
ADVANCED FUNCTIONAL MATERIALS |
2020 |
30 |
|
|
Antifungal-Inbuilt Metal-Organic-Frameworks Eradicate Candida albicans Biofilms |
ADVANCED FUNCTIONAL MATERIALS |
2020 |
30 |
|
|
Nanotechnology-based antimicrobials and delivery systems for biofilm-infection control |
CHEMICAL SOCIETY REVIEWS |
2019 |
48 |
428 |
446 |
Artificial Channels in an Infectious Biofilm Created by Magnetic Nanoparticles Enhanced Bacterial Killing by Antibiotics |
SMALL |
2019 |
15 |
|
|
Emergent heterogeneous microenvironments in biofilms: substratum surface heterogeneity and bacterial adhesion force-sensing |
FEMS MICROBIOLOGY REVIEWS |
2018 |
42 |
259 |
272 |
Physico-chemistry from initial bacterial adhesion to surface-programmed biofilm growth |
ADVANCES IN COLLOID AND INTERFACE SCIENCE |
2018 |
261 |
1 |
14 |
Ten most cited papers (per July 2021):
Title |
Journal |
Year |
Volume |
Beginning Page |
Total citations |
Physico-chemistry of initial microbial adhesive interactions - its mechanisms and methods for study |
FEMS MICROBIOLOGY REVIEWS |
1999 |
23 |
179 |
818 |
Measurement of the surface free-energy of bacterial-cell surfaces and its relevance for adhesion |
APPLIED AND ENVIRONMENTAL MICROBIOLOGY |
1984 |
48 |
980 |
535 |
Biomaterial-Associated Infection: Locating the Finish Line in the Race for the Surface |
SCIENCE TRANSLATIONAL MEDICINE |
2012 |
4 |
|
400 |
The effect of surface roughening of polymers on measured contact angles of liquids |
COLLOIDS AND SURFACES |
1984 |
9 |
319 |
388 |
In vitro and in vivo antimicrobial activity of covalently coupled quaternary ammonium silane coatings on silicone rubber |
BIOMATERIALS |
2002 |
23 |
1417 |
353 |
Antimicrobial effects of positively charged surfaces on adhering Gram-positive and Gram-negative bacteria |
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY |
2001 |
48 |
7 |
351 |
Electrochemical and surface characterization of a nickel-titanium alloy |
BIOMATERIALS |
1998 |
19 |
761 |
347 |
The influence of surface free-energy and surface-roughness on early plaque-formation - an in vivo study in man |
JOURNAL OF CLINICAL PERIODONTOLOGY |
1990 |
17 |
138 |
320 |
Electric double layer interactions in bacterial adhesion to surfaces |
SURFACE SCIENCE REPORTS |
2002 |
47 |
3 |
308 |
Specific and nonspecific interactions in bacterial adhesion to solid substrata |
FEMS MICROBIOLOGY LETTERS |
1987 |
46 |
165 |
305 |
Laatst gewijzigd: | 19 januari 2024 16:50 |