G. (Giovanni) Maglia, Prof

Telephone:

E-mail:

giovanni.maglia rug.nl

Research interests

The main focus of our group is on the chemistry and biophysics of nanopores. We are engineering, modifying and redesigning these protein systems for applications in NanoBioTechnology and Single-Molecule Biophysics.

We are using biological nanopores in:

• Single-molecule enzymology

• Single-molecule sensing and DNA analysis

• Protein components for nanomachines

Research Group Webpage -Google pages

Research Group RUG Webpage

Publications

Controlling Electroosmosis in Nanopores Without Altering the Nanopore Sensing Region

Baldelli, M., Muccio, G. D., Sauciuc, A., Rocca, B. M. D., Viola, F., Balme, S., Bonini, A., Maglia, G. & Chinappi, M., 11-Jun-2024, (E-pub ahead of print) In: Advanced materials. 21 p., 2401761.

Research output: Contribution to journal › Article › Academic › peer-review

Engineered nanopores for exopeptidase protein sequencing

Bonini, A., Sauciuc, A. & Maglia, G., Jan-2024, In: Nature Methods. 21, p. 16-17 2 p.

Research output: Contribution to journal › Article › Academic › peer-review

Nanobody-functionalized biological nanopores and means and methods related thereto

Maglia, G. (Inventor), Zhang, X. (Inventor) & Kjems, J. (Inventor), 6-Jun-2024, Patent No. WO2024117910, 1-Dec-2023, Priority date 2-Dec-2022

Research output: Patent

Nanopore-based analysis of proteins

Maglia, G. (Inventor), Zhang, S. (Inventor) & Heron, A. (Inventor), 2-May-2024, Patent No. WO2024091124, 30-Oct-2023, Priority date 28-Oct-2022

Research output: Patent

Nanopore systems and methods for single-molecule polymer profiling

Maglia, G. (Inventor) & Sauciuc, A. (Inventor), 2-May-2024, Patent No. WO2024091123, 30-Oct-2023, Priority date 28-Oct-2022

Research output: Patent

Unravelled proteins form blobs during translocation across nanopores

Sauciuc, A., Whittaker, J., Tadema, M., Tych, K., Guskov, A. & Maglia, G., 25-Jan-2024, (Submitted) In: bioRxiv. 11 p.

Research output: Contribution to journal › Article › Academic

Visible Light Control over the Cytolytic Activity of a Toxic Pore-Forming Protein

Volarić, J., van der Heide, N. J., Mutter, N. L., Samplonius, D. F., Helfrich, W., Maglia, G., Szymanski, W. & Feringa, B. L., 16-Feb-2024, In: ACS chemical biology. 19, 2, p. 451–461 11 p., 3c00640.

Research output: Contribution to journal › Article › Academic › peer-review

Evidence of Cytolysin A nanopore incorporation in mammalian cells assessed by a graphical user interface

Lucas, F. L. R., Finol-Urdaneta, R. K., Van Thillo, T., McArthur, J. R., van der Heide, N. J., Maglia, G., Dedecker, P., Strauss, O. & Wloka, C., Oct-2023, In: Nanoscale. 15, 23, p. 16914–16923 10 p.

Research output: Contribution to journal › Article › Academic › peer-review

Hydrophobically gated memristive nanopores for neuromorphic applications

Paulo, G., Sun, K., Di Muccio, G., Gubbiotti, A., Morozzo della Rocca, B., Geng, J., Maglia, G., Chinappi, M. & Giacomello, A., Dec-2023, In: Nature Communications. 14, 1, 9 p., 8390.

Research output: Contribution to journal › Article › Academic › peer-review

Protein Sizing with 15 nm Conical Biological Nanopore YaxAB

Straathof, S., Di Muccio, G., Yelleswarapu, M., Alzate Banguero, M., Wloka, C., van der Heide, N. J., Chinappi, M. & Maglia, G., 25-Jul-2023, In: Acs Nano. 17, 14, p. 13685–13699

Research output: Contribution to journal › Article › Academic › peer-review