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About us Practical matters How to find us prof. dr. F. (Folkert) Kuipers
University Medical Center Groningen

prof. dr. F. (Folkert) Kuipers

Profile picture of prof. dr. F. (Folkert) Kuipers
E-mail:
f.kuipers umcg.nl
Research interests Publications Press/media

Research interests

 

- Physiology and pathophysiology of the enterohepatic circulation in humans and experimental animals: hepatic and intestinal transport systems, mechanisms of bile formation and cholestasis, (patho)physiology of biliary lipid secretion, metabolic control by bile acids via newly identified signaling cascades

- Hepatic lipid metabolism in humans and experimental animals: lipoprotein assembly and secretion, causes and consequences of hepatic steatosis, interactions between carbohydrate and lipid metabolism, inborn errors of metabolism, inflammatory pathways, role of nuclear receptors (LXR, CHREBP)

- Regulation of cholesterol synthesis and trafficking: transcription factors and nuclear receptors (SREBP/PPAR/FXR/LXR) and transporter proteins, perinatal development, metabolic programming, application of stable isotope approaches

- Quantification of metabolic fluxes by stable isotope procedures

 

Publications

Changes in bile acid composition are correlated with reduced intestinal cholesterol uptake in intestine-specific WASH-deficient mice

Heida, A., van Dijk, T., Smit, M., Koehorst, M., Koster, M., Kloosterhuis, N., Havinga, R., Bloks, V. W., Wolters, J. C., de Bruin, A., Kuivenhoven, J. A., de Boer, J. F., Kuipers, F. & van de Sluis, B., Mar-2024, In: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1869, 2, 11 p., 159445.

Research output: Contribution to journal › Article › Academic › peer-review

Characterization of milk oligosaccharide and sialic acid content and their influence on brain sialic acid in a lean mouse model for gestational diabetes

Liu, F., Tol, A. J. C., Kuipers, F., Oosterveer, M. H., van der Beek, E. M. & van Leeuwen, S. S., 15-Feb-2024, In: Heliyon. 10, 3, 13 p., e24539.

Research output: Contribution to journal › Article › Academic › peer-review

Comparative Analysis of Digestion Methods for Bile Proteomics: The Key to Unlocking Biliary Biomarker Potential

Thorne, A. M., Hoekzema, M., Porte, R. J., Kuipers, F., de Meijer, V. E. & Wolters, J. C., 2024, In: Analytical Chemistry. 96, 36, p. 14393–14404 12 p.

Research output: Contribution to journal › Article › Academic › peer-review

Corrigendum to “Adipocyte-specific FXR-deficiency protects adipose tissue from oxidative stress and insulin resistance and improves glucose homeostasis” [Mol Metab 69 (2023) 1–13]

Dehondt, H., Marino, A., Butruille, L., Mogilenko, D. A., Nzoussi Loubota, A. C., Chávez-Talavera, O., Dorchies, E., Vallez, E., Haas, J., Derudas, B., Bongiovanni, A., Tardivel, M., Kuipers, F., Lefebvre, P., Lestavel, S., Tailleux, A., Dombrowicz, D., Caron, S. & Staels, B., Jul-2024, In: Molecular metabolism. 85, 1 p., 101961.

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

Dietary cystine restriction increases the proliferative capacity of the small intestine of mice

de Jong, J. C. W., van Rooijen, K. S., Stigter, E. C. A., Gülersönmez, M. C., de Zoete, M. R., Top, J., Baars, M. J. D., Vercoulen, Y., Kuipers, F., van Mil, S. W. C. & Ijssennagger, N., 5-Jan-2024, In: PLoS ONE. 19, 1, 15 p., e0290493.

Research output: Contribution to journal › Article › Academic › peer-review

Elevated plasma bile acids coincide with cardiac stress and inflammation in young Cyp2c70−/− mice

de Vries, H. D., Eijgenraam, T. R., Bloks, V. W., Mulder, N. L., van Zutphen, T., Silljé, H. H. W., Kuipers, F. & de Boer, J. F., 2-Oct-2024, (E-pub ahead of print) In: Pediatric Research. 8 p.

Research output: Contribution to journal › Article › Academic › peer-review

Oral Anaerobutyricum soehngenii augments glycemic control in type 2 diabetes

Attaye, I., Witjes, J. J., Koopen, A. M., van der Vossen, E. W. J., Zwirs, D., Wortelboer, K., Collard, D., Kemper, E. M., Winkelmeijer, M., Holst, J. J., Hazen, S. L., Kuipers, F., Stroes, E. S. G., Groen, A. K., de Vos, W. M., Nieuwdorp, M. & Herrema, H., 16-Aug-2024, In: Iscience. 27, 8, 14 p., 110455.

Research output: Contribution to journal › Article › Academic › peer-review

Reversal of insulin resistance in people with obesity by lifestyle-induced weight loss does not impact the proportion of circulating 12α-hydroxylated bile acids

Palmiotti, A., Berk, K. A., Koehorst, M., Hovingh, M. V., Pranger, A. T., van Faassen, M., de Boer, J. F., van der Valk, E. S., van Rossum, E. F. C., Mulder, M. T. & Kuipers, F., Sept-2024, In: Diabetes, Obesity and Metabolism. 26, 9, p. 4019-4029 11 p.

Research output: Contribution to journal › Article › Academic › peer-review

Supplementation of Seaweed Extracts to the Diet Reduces Symptoms of Alzheimer's Disease in the APPswePS1ΔE9 Mouse Model

Martens, N., Zhan, N., Yam, S. C., Leijten, F. P. J., Palumbo, M., Caspers, M., Tiane, A., Friedrichs, S., Li, Y., van Vark-van der Zee, L., Voortman, G., Zimetti, F., Jaarsma, D., Verschuren, L., Jonker, J. W., Kuipers, F., Lütjohann, D., Vanmierlo, T. & Mulder, M. T., 25-May-2024, In: Nutrients. 16, 11, 36 p., 1614.

Research output: Contribution to journal › Article › Academic › peer-review

Transmission and dynamics of mother-infant gut viruses during pregnancy and early life

Lifelines NEXT cohort study, Garmaeva, S., Sinha, T., Gulyaeva, A., Kuzub, N., Spreckels, J. E., Andreu-Sánchez, S., Gacesa, R., Vich Vila, A., Brushett, S., Kruk, M., Dekens, J., Sikkema, J., Kuipers, F., Shkoporov, A. N., Hill, C., Scherjon, S., Wijmenga, C., Fu, J. & Kurilshikov, A.& 1 others, Zhernakova, A., 2-Mar-2024, In: Nature Communications. 15, 1, 19 p., 1945.

Research output: Contribution to journal › Article › Academic › peer-review

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Press/media

Verouderingsproces tegenhouden

Kuipers, F.

21/08/2024 → 23/08/2024

Press/Media: Expert Comment › Popular

Verouderingsonderzoek Eriba bestaat 10 jaar: ‘Zoeken naar medicijnen om gezond te blijven’

Kuipers, F.

14/12/2023

Press/Media: Expert Comment › Popular

Journal News - From the Journals

Kuipers, F.

01/10/2019

Press/Media: Other › Academic

De rol van het microbioom bij het ontstaan van hart- en vaatziekten

Koonen, D. & Kuipers, F.

01/05/2019

Press/Media: Research › Popular

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