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About us Practical matters How to find us prof. dr. F. (Folkert) Kuipers

University Medical Center Groningen

prof. dr. F. (Folkert) Kuipers

Faculty of Medical Sciences

Telephone:

+31 50 361 6620

E-mail:

f.kuipers umcg.nl

ORCID Research Portal

Research interests

- Physiology and pathophysiology of the enterohepatic circulation in humans and experimental animals: hepatic and intestinal transport systems, mechanisms of bile formation and cholestasis, (patho)physiology of biliary lipid secretion, metabolic control by bile acids via newly identified signaling cascades

- Hepatic lipid metabolism in humans and experimental animals: lipoprotein assembly and secretion, causes and consequences of hepatic steatosis, interactions between carbohydrate and lipid metabolism, inborn errors of metabolism, inflammatory pathways, role of nuclear receptors (LXR, CHREBP)

- Regulation of cholesterol synthesis and trafficking: transcription factors and nuclear receptors (SREBP/PPAR/FXR/LXR) and transporter proteins, perinatal development, metabolic programming, application of stable isotope approaches

- Quantification of metabolic fluxes by stable isotope procedures

Publications

Changes in bile acid composition are correlated with reduced intestinal cholesterol uptake in intestine-specific WASH-deficient mice

Heida, A., van Dijk, T., Smit, M., Koehorst, M., Koster, M., Kloosterhuis, N., Havinga, R., Bloks, V. W., Wolters, J. C., de Bruin, A., Kuivenhoven, J. A., de Boer, J. F., Kuipers, F. & van de Sluis, B., Mar-2024, In: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1869, 2, 11 p., 159445.

Research output: Contribution to journal › Article › Academic › peer-review

Characterization of milk oligosaccharide and sialic acid content and their influence on brain sialic acid in a lean mouse model for gestational diabetes

Liu, F., Tol, A. J. C., Kuipers, F., Oosterveer, M. H., van der Beek, E. M. & van Leeuwen, S. S., 15-Feb-2024, In: Heliyon. 10, 3, 13 p., e24539.

Research output: Contribution to journal › Article › Academic › peer-review

Dietary cystine restriction increases the proliferative capacity of the small intestine of mice

de Jong, J. C. W., van Rooijen, K. S., Stigter, E. C. A., Gülersönmez, M. C., de Zoete, M. R., Top, J., Baars, M. J. D., Vercoulen, Y., Kuipers, F., van Mil, S. W. C. & Ijssennagger, N., 5-Jan-2024, In: PLoS ONE. 19, 1, 15 p., e0290493.

Research output: Contribution to journal › Article › Academic › peer-review

Supplementation of Seaweed Extracts to the Diet Reduces Symptoms of Alzheimer's Disease in the APPswePS1ΔE9 Mouse Model

Martens, N., Zhan, N., Yam, S. C., Leijten, F. P. J., Palumbo, M., Caspers, M., Tiane, A., Friedrichs, S., Li, Y., van Vark-van der Zee, L., Voortman, G., Zimetti, F., Jaarsma, D., Verschuren, L., Jonker, J. W., Kuipers, F., Lütjohann, D., Vanmierlo, T. & Mulder, M. T., 25-May-2024, In: Nutrients. 16, 11

Research output: Contribution to journal › Article › Academic › peer-review

Transmission and dynamics of mother-infant gut viruses during pregnancy and early life

Lifelines NEXT cohort study, Garmaeva, S., Sinha, T., Gulyaeva, A., Kuzub, N., Spreckels, J. E., Andreu-Sánchez, S., Gacesa, R., Vich Vila, A., Brushett, S., Kruk, M., Dekens, J., Sikkema, J., Kuipers, F., Shkoporov, A. N., Hill, C., Scherjon, S., Wijmenga, C., Fu, J., Kurilshikov, A., & 1 othersZhernakova, A., 2-Mar-2024, In: Nature Communications. 15, 1, 19 p., 1945.

Research output: Contribution to journal › Article › Academic › peer-review

Unraveling interindividual variation of trimethylamine N-oxide and its precursors at the population level

Andreu-Sánchez, S., Ahmad, S., Kurilshikov, A., Beekman, M., Ghanbari, M., van Faassen, M., van den Munckhof, I. C. L., Steur, M., Harms, A., Hankemeier, T., Ikram, M. A., Kavousi, M., Voortman, T., Kraaij, R., Netea, M. G., Rutten, J. H. W., Riksen, N. P., Zhernakova, A., Kuipers, F., Slagboom, P. E., & 3 othersvan Duijn, C. M., Fu, J. & Vojinovic, D., 2024, (Accepted/In press) In: iMeta.

Research output: Contribution to journal › Article › Academic › peer-review

Absence of gut microbiota reduces neonatal survival and exacerbates liver disease in Cyp2c70-deficient mice with a human-like bile acid composition

Sjöland, W., Wahlström, A., Makki, K., Schöler, M., Molinaro, A., Olsson, L., Greiner, T. U., Caesar, R., de Boer, J. F., Kuipers, F., Bäckhed, F. & Marschall, H-U., 14-Jul-2023, In: Clinical Science. 137, 13, p. 995-1011 17 p.

Research output: Contribution to journal › Article › Academic › peer-review

Activation of Liver X Receptors and Peroxisome Proliferator-Activated Receptors by Lipid Extracts of Brown Seaweeds: A Potential Application in Alzheimer's Disease?

Martens, N., Zhan, N., Voortman, G., Leijten, F. P. J., van Rheenen, C., van Leerdam, S., Geng, X., Huybrechts, M., Liu, H., Jonker, J. W., Kuipers, F., Lütjohann, D., Vanmierlo, T. & Mulder, M. T., 30-Jun-2023, In: Nutrients. 15, 13, 24 p., 3004.

Research output: Contribution to journal › Article › Academic › peer-review

Adipocyte-specific FXR-deficiency protects adipose tissue from oxidative stress and insulin resistance and improves glucose homeostasis

Dehondt, H., Marino, A., Butruille, L., Mogilenko, D. A., Nzoussi Loubota, A. C., Chávez-Talavera, O., Dorchies, E., Vallez, E., Haas, J., Derudas, B., Bongiovanni, A., Tardivel, M., Kuipers, F., Lefebvre, P., Lestavel, S., Tailleux, A., Dombrowicz, D., Caron, S. & Staels, B., Mar-2023, In: Molecular metabolism. 69, 13 p., 101686.

Research output: Contribution to journal › Article › Academic › peer-review

Bile Acid Sequestration via Colesevelam Reduces Bile Acid Hydrophobicity and Improves Liver Pathology in Cyp2c70-/- Mice with a Human-like Bile Acid Composition

Palmiotti, A., de Vries, H. D., Hovingh, M. V., Koehorst, M., Mulder, N. L., Verkade, E., Veentjer, M. K., van Dijk, T. H., Bloks, V. W., Havinga, R., Verkade, H. J., de Boer, J. F. & Kuipers, F., 8-Sept-2023, In: Biomedicines. 11, 9, 15 p., 2495.

Research output: Contribution to journal › Article › Academic › peer-review

All (466) publications

Press/media

Verouderingsonderzoek Eriba bestaat 10 jaar: ‘Zoeken naar medicijnen om gezond te blijven’

Kuipers, F.

14/12/2023

Press/Media: Expert Comment › Popular

Journal News - From the Journals

Kuipers, F.

01/10/2019

Press/Media: Other › Academic

De rol van het microbioom bij het ontstaan van hart- en vaatziekten

Koonen, D. & Kuipers, F.

01/05/2019

Press/Media: Research › Popular

All (3) press/media

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