dr. F.J. (Frank) Dekker

Associate professor Pharmaceutical Epigenetics

Faculty of Science and Engineering

Telephone:

+31 6 3192 1118 (0031-6-31921118)

E-mail:

f.j.dekker rug.nl

Homepage ORCID Research Portal

Publications

Changes in histone lysine acetylation, but not DNA methylation during facultative hibernation in Syrian hamster liver

Dekker, F., 1-Sept-2024, In: Epigenetics Communications. p. 1 14 p., 4:1.

Research output: Contribution to journal › Article › Academic › peer-review

Exploration of Hydrazide-Based HDAC8 PROTACs for the Treatment of Hematological Malignancies and Solid Tumors

Zhao, C., Zhang, J., Zhou, H., Setroikromo, R., Poelarends, G. & Dekker, F., 22-Aug-2024, In: Journal of Medicinal Chemistry. 67, 16, p. 14016–14039 24 p.

Research output: Contribution to journal › Article › Academic › peer-review

Impact of HDAC inhibitors on macrophage polarization to enhance innate immunity against infections

Bhat, M. F., Srdanović, S., Sundberg, L.-R., Einarsdóttir, H. K., Marjomäki, V. & Dekker, F. J., Nov-2024, In: Drug Discovery Today. 29, 11, 15 p., 104193.

Research output: Contribution to journal › Review article › peer-review

Small Molecule MIF Modulation Enhances Ferroptosis by Impairing DNA Repair Mechanisms

Chen, D., Zhao, C., Zhang, J., Knol, C. W. J., Osipyan, A., Majerníková, N., Chen, T., Xiao, Z., Adriana, J., Griffith, A. J., Gamez, A. S., van der Wouden, P. E., Coppes, R. P., Dolga, A. M., Haisma, H. J. & Dekker, F. J., 27-Aug-2024, In: Advanced science . 11, 32, 15 p., e2403963.

Research output: Contribution to journal › Article › Academic › peer-review

The synthesis of 1,2,3-triazoles as binders of D-dopachrome tautomerase (D-DT) for the development of dual-targeting inhibitors

Osipyan, A., Bulai, R. G., Wu, Z., de Witte, J., van der Velde, J. J. H., Kader, M., van der Wouden, P. E., Poelarends, G. J. & Dekker, F. J., 5-Oct-2024, In: European Journal of Medicinal Chemistry. 276, 116665.

Research output: Contribution to journal › Article › Academic › peer-review

Allosteric Inhibitors of Macrophage Migration Inhibitory Factor (MIF) Interfere with Apoptosis-Inducing Factor (AIF) Co-Localization to Prevent Parthanatos

Chen, D., Osipyan, A., Adriana, J., Kader, M., Gureev, M., Knol, C. W. J., Sigmund, M. C., Xiao, Z., van der Wouden, P. E., Cool, R. H., Poelarends, G. J. & Dekker, F. J., 13-Jul-2023, In: Journal of Medicinal Chemistry. 66, 13, p. 8767-8781 15 p.

Research output: Contribution to journal › Article › Academic › peer-review

Discovery of highly potent HDAC8 PROTACs with anti-tumor activity

Zhao, C., Chen, D., Suo, F.-Z., Setroikromo, R., Quax, W. J. & Dekker, F., Jul-2023, In: Bioorganic Chemistry. 136, 16 p., 106546.

Research output: Contribution to journal › Article › Academic › peer-review

First-in-Class Selective Inhibitors of the Lysine Acetyltransferase KAT8

Fiorentino, F., Sementilli, S., Menna, M., Turrisi, F., Tomassi, S., Pellegrini, F. R., Iuzzolino, A., D’Acunzo, F., Feoli, A., Wapenaar, H., Taraglio, S., Fraschetti, C., Del Bufalo, D., Sbardella, G., Dekker, F. J., Paiardini, A., Trisciuoglio, D., Mai, A. & Rotili, D., 8-May-2023, In: Journal of Medicinal Chemistry. 66, 10, p. 6591–6616 26 p.

Research output: Contribution to journal › Article › Academic › peer-review

Histone Deacetylase 3-Directed PROTACs Have Anti-inflammatory Potential by Blocking Polarization of M0-like into M1-like Macrophages

Zhao, C., Chen, S., Chen, D., Río-Bergé, C., Zhang, J., Ettema, P., Daemen, T. & Dekker, F. J., 16-Oct-2023, In: Angewandte Chemie (International ed. in English). 62, 42, 11 p., e202310059.

Research output: Contribution to journal › Article › Academic › peer-review

Identification and Characterization of a Small Molecule that Activates Thiosulfate Sulfurtransferase and Stimulates Mitochondrial Respiration

Al-Dahmani, Z. M., Hadian, M., Ruiz-Moreno, A. J., Maria, S.-G. A., Batista, F. A., Zhang, R., Luo, Y., Sadremomtaz, A., van der Straat, R., Spoor, M., Dolga, A. M., Dekker, F. J., S S, A. D., van Goor, H. & Groves, M. R., Nov-2023, In: Protein Science. 32, 11, 18 p., e4794.

Research output: Contribution to journal › Article › Academic › peer-review