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E. (Els) van der Goot

Researcher

Faculty of Science and Engineering

Telephone:

E-mail:

e.van.der.goot rug.nl

ORCID Research Portal

Research interests

PhD project: The role of the microbiome in disease-associated mental and behavioral problems - The case of phenylketonuria (PKU)

I’m interested in the link between the microbiome, brain and behaviour. I study this link under a pathological condition called phenylketonuria (PKU), which is a metabolic disorder in which there is an inability to convert phenylalanine into tyrosine. This can lead to behavioural changes as deficits in learning and memory, increase in depression- and anxiety-like behaviours and sleep loss. I want to examine to what extend these behavioural problems are related to the microbial communities present in the gut in PKU mice.

Publications

Phenylketonuria in a microbial world: Gut-microbiome-brain interactions shaping behavior in PKU

van der Goot, E., 2023, [Groningen]: University of Groningen. 225 p.

Research output: Thesis › Thesis fully internal (DIV)

Gut-microbiome composition in response to phenylketonuria depends on dietary phenylalanine in BTBR Pahenu2 mice

van der Goot, E., Vink, S. N., van Vliet, D., van Spronsen, F. J., Falcao Salles, J. & van der Zee, E. A., 4-Jan-2022, In: Frontiers in nutrition. 8, 16 p., 735366.

Research output: Contribution to journal › Article › Academic › peer-review

The increasing importance of LNAA supplementation in phenylketonuria at higher plasma phenylalanine concentrations

van Vliet, D., van der Goot, E., van Ginkel, W. G., van Faassen, H. J. R., de Blaauw, P., Kema, I. P., Heiner-Fokkema, M. R., van der Zee, E. A. & van Spronsen, F. J., Jan-2022, In: Molecular Genetics and Metabolism. 135, 1, p. 27-34 8 p.

Research output: Contribution to journal › Article › Academic › peer-review

Correlations of blood and brain biochemistry in phenylketonuria: Results from the Pah-enu2 PKU mouse

Dijkstra, A. M., van Vliet, N., van Vliet, D., Romani, C., Huijbregts, S. C. J., van der Goot, E., Hovens, I. B., van der Zee, E. A., Kema, I. P., Heiner-Fokkema, M. R. & van Spronsen, F. J., Nov-2021, In: Molecular Genetics and Metabolism. 134, 3, p. 250-256 7 p.

Research output: Contribution to journal › Article › Academic › peer-review

A microbial community ecology perspective on the gut-microbiome-brain axis

van der Goot, E., van Spronsen, F. J., Falcão Salles, J. & van der Zee, E. A., 2-Sept-2020, In: Frontiers in endocrinology. 11, p. 611 611.

Research output: Contribution to journal › Article › Academic › peer-review

Blood and brain biochemistry and behaviour in NTBC and dietary treated tyrosinemia type 1 mice

van Ginkel, W. G., van Vliet, D., van der Goot, E., Faassen, M. H. J. R., Vogel, A., Heiner-Fokkema, M. R., van der Zee, E. A. & van Spronsen, F. J., 16-Oct-2019, In: Nutrients. 11, 10, 13 p., 2486.

Research output: Contribution to journal › Article › Academic › peer-review

Hippocampal microglia modifications in C57Bl/6 Pahenu2 and BTBR Pahenu2 phenylketonuria (PKU) mice depend on the genetic background, irrespective of disturbed sleep patterns

van der Goot, E., Bruinenberg, V. M., Hormann, F. M., Eisel, U. L. M., van Spronsen, F. J. & van der Zee, E. A., Apr-2019, In: Neurobiology of Learning and Memory. 160, p. 139-143 5 p.

Research output: Contribution to journal › Article › Academic › peer-review

Long-term dietary intervention with low Phe and/or a specific nutrient combination improve certain aspects of brain functioning in phenylketonuria (PKU)

Bruinenberg, V. M., van Vliet, D., van der Goot, E., Counotte, D. S., Kuhn, M., van Spronsen, F. J. & van der Zee, E. A., 15-Mar-2019, In: PLoS ONE. 14, 3, 20 p., 0213391.

Research output: Contribution to journal › Article › Academic › peer-review

The benefit of large neutral amino acid supplementation to a liberalized phenylalanine-restricted diet in adult phenylketonuria patients: Evidence from adult Pah-Enu2 mice

van Vliet, D., van der Goot, E., van Ginkel, W. G., van Faassen, M. H. J. R., de Blaauw, P., Kema, I. P., Martinez, A., Heiner-Fokkema, M. R., van der Zee, E. A. & van Spronsen, F. J., Sept-2019, In: Nutrients. 11, 9, 14 p., 2252.

Research output: Contribution to journal › Article › Academic › peer-review

Large neutral amino acid supplementation as an alternative to the phenylalanine-restricted diet in adults with phenylketonuria: Evidence from adult Pah-enu2 mice

van Vliet, D., van der Goot, E., Bruinenberg, V. M., van Faassen, M., de Blaauw, P., Kema, I. P., Heiner-Fokkema, M. R., van der Zee, E. A. & van Spronsen, F. J., Mar-2018, In: Journal of Nutritional Biochemistry. 53, p. 20-27 8 p.

Research output: Contribution to journal › Article › Academic › peer-review

All (11) publications

Press/media

Balancing behavior and the microbiome: Meet Els van der Goot

van der Goot, E., Falcao Salles, J. & van der Zee, E.

15/04/2019

Press/Media: Research › Professional

All (1) press/media

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