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A. Osipyan, MSc

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Faculty of Science and Engineering

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Publications

Access to nitrogen-nitrogen bond-containing heterocycles through substrate promiscuity of piperazate synthases

Li, Y., Osipyan, A., de Kok, N. A. W., Schröder, S., Founti, M., Fodran, P., van Merkerk, R., Maier, A., Tischler, D. & Schmidt, S., 17-Feb-2025, (Submitted) ChemRxiv.

Research output: Working paper › Preprint › Academic

Correction to “Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione Derivative Inhibits d-Dopachrome Tautomerase Activity and Suppresses the Proliferation of Non-Small Cell Lung Cancer Cells”Article link copied!

Xiao, Z., Osipyan, A., Song, S., Chen, D., Schut, R. A., van Merkerk, R., van der Wouden, P. E., Cool, R. H., Quax, W. J., Melgert, B. N., Poelarends, G. J. & Dekker, F. J., 27-Mar-2025, In: Journal of Medicinal Chemistry. 68, 6, p. 6844-6845 2 p.

Research output: Contribution to journal › Erratum

Recent Developments and Challenges in the Enzymatic Formation of Nitrogen–Nitrogen Bonds

Angeli, C., Atienza-Sanz, S., Schröder, S., Hein, A., Li, Y., Argyrou, A., Osipyan, A., Terholsen, H. & Schmidt, S., 3-Jan-2025, In: ACS Catalysis. 15, 1, p. 310-342 33 p.

Research output: Contribution to journal › Article › Academic › peer-review

Small Molecule MIF Modulation Enhances Ferroptosis by Impairing DNA Repair Mechanisms

Chen, D., Zhao, C., Zhang, J., Knol, C. W. J., Osipyan, A., Majerníková, N., Chen, T., Xiao, Z., Adriana, J., Griffith, A. J., Soto-Gamez, A., van der Wouden, P. E., Coppes, R. P., Dolga, A. M., Haisma, H. J. & Dekker, F. J., 27-Aug-2024, In: Advanced science . 11, 32, 15 p., e2403963.

Research output: Contribution to journal › Article › Academic › peer-review

The synthesis of 1,2,3-triazoles as binders of D-dopachrome tautomerase (D-DT) for the development of dual-targeting inhibitors

Osipyan, A., Bulai, R. G., Wu, Z., de Witte, J., van der Velde, J. J. H., Kader, M., van der Wouden, P. E., Poelarends, G. J. & Dekker, F. J., 5-Oct-2024, In: European Journal of Medicinal Chemistry. 276, 116665.

Research output: Contribution to journal › Article › Academic › peer-review

Allosteric Inhibitors of Macrophage Migration Inhibitory Factor (MIF) Interfere with Apoptosis-Inducing Factor (AIF) Co-Localization to Prevent Parthanatos

Chen, D., Osipyan, A., Adriana, J., Kader, M., Gureev, M., Knol, C. W. J., Sigmund, M. C., Xiao, Z., van der Wouden, P. E., Cool, R. H., Poelarends, G. J. & Dekker, F. J., 13-Jul-2023, In: Journal of Medicinal Chemistry. 66, 13, p. 8767-8781 15 p.

Research output: Contribution to journal › Article › Academic › peer-review

Design and synthesis of ligands targeting MIF family enzymes and their application in medicinal chemistry

Osipyan, A., 2023, [Groningen]: University of Groningen. 135 p.

Research output: Thesis › Thesis fully internal (DIV)

Thieno[2,3- d]pyrimidine-2,4(1 H,3 H)-dione Derivative Inhibits d -Dopachrome Tautomerase Activity and Suppresses the Proliferation of Non-Small Cell Lung Cancer Cells

Xiao, Z., Osipyan, A., Song, S., Chen, D., Schut, R. A., van Merkerk, R., van der Wouden, P. E., Cool, R. H., Quax, W. J., Melgert, B. N., Poelarends, G. J. & Dekker, F. J., 10-Feb-2022, In: Journal of Medicinal Chemistry. 65, 3, p. 2059-2077

Research output: Contribution to journal › Article › Academic › peer-review

Epigenetic regulation in macrophage migration inhibitory factor (MIF)-mediated signaling in cancer and inflammation

Osipyan, A., Chen, D. & Dekker, F. J., Jul-2021, In: Drug Discovery Today. 26, 7, p. 1728-1734

Research output: Contribution to journal › Review article › peer-review

Automated, Accelerated Nanoscale Synthesis of Iminopyrrolidines

Osipyan, A., Shaabani, S., Warmerdam, R., Shishkina, S. V., Boltz, H. & Dömling, A., 20-Jul-2020, In: Angewandte Chemie (International ed. in English). 59, 30, p. 12423-12427

Research output: Contribution to journal › Article › Academic › peer-review

All (13) publications

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