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About us Practical matters How to find us dr. A.M.W.H. (Andy-Mark) Thunnissen

dr. A.M.W.H. (Andy-Mark) Thunnissen

Assistant Professor

Faculty of Science and Engineering

Telephone:

+31 50 36 34380

E-mail:

a.m.w.h.thunnissen rug.nl

Homepage ORCID Research Portal

Publications

Adapting an acyl CoA ligase from Metallosphaera sedula for lactam formation by structure-guided protein engineering

Capra, N., Lelièvre, C., Touré, O., Fossey-Jouenne, A., Vergne-Vaxelaire, C., Janssen, D., Thunnissen, A.-M. W. H. & Zaparucha, A., 4-Mar-2024, In: Frontiers in Catalysis. 4, 17 p., 1360129.

Research output: Contribution to journal › Article › Academic › peer-review

Boron catalysis in a designer enzyme

Longwitz, L., Leveson-Gower, R. B., Rozeboom, H. J., Thunnissen, A.-M. W. H. & Roelfes, G., 23-May-2024, In: Nature. 629, p. 824–829 17 p.

Research output: Contribution to journal › Article › Academic › peer-review

Regio- and stereoselective steroid hydroxylation by CYP109A2 from Bacillus megaterium explored by X-ray crystallography and computational modeling

Jóźwik, I. K., Bombino, E., Abdulmughni, A., Hartz, P., Rozeboom, H. J., Wijma, H. J., Kappl, R., Janssen, D. B., Bernhardt, R. & Thunnissen, A.-M. W. H., Oct-2023, In: The FEBS Journal. 290, 20, p. 5016-5035 20 p.

Research output: Contribution to journal › Article › Academic › peer-review

Gene Fusion and Directed Evolution to Break Structural Symmetry and Boost Catalysis by an Oligomeric C‐C Bond‐Forming Enzyme

Xu, G., Kunzendorf, A., Crotti, M., Rozeboom, H. J., Thunnissen, A.-M. W. H. & Poelarends, G. J., 14-Feb-2022, In: Angewandte Chemie International Edition. 61, 8, 6 p., e202113970.

Research output: Contribution to journal › Article › Academic › peer-review

The Role of Tryptophan in π Interactions in Proteins: An Experimental Approach

Shao, J., Kuiper, B. P., Thunnissen, A.-M. W. H., Cool, R. H., Zhou, L., Huang, C., Dijkstra, B. W. & Broos, J., Sept-2022, In: Journal of the American Chemical Society. 144, 30, p. 13815-13822 8 p., 04986.

Research output: Contribution to journal › Article › Academic › peer-review

Biocatalytic Enantioselective Hydroaminations Enabling Synthesis of N-Arylalkyl-Substituted L-Aspartic Acids

Abidin, M. M., Thangavelu, S., Bothof, L., Tepper, P., Thunnissen, A.-M. & Poelarends, G. J., Aug-2021, In: Organic & Biomolecular Chemistry. 19, 29, p. 6407–6411 12 p.

Research output: Contribution to journal › Article › Academic › peer-review

Computational Redesign of an ω-Transaminase from Pseudomonas jessenii for Asymmetric Synthesis of Enantiopure Bulky Amines

Meng, Q., Ramírez-Palacios, C., Capra, N., Hooghwinkel, M. E., Thallmair, S., Rozeboom, H. J., Thunnissen, A. M. W. H., Wijma, H. J., Marrink, S. J. & Janssen, D. B., Aug-2021, In: ACS Catalysis. 11, 17, p. 10733-10747 15 p.

Research output: Contribution to journal › Article › Academic › peer-review

Unlocking Asymmetric Michael Additions in an Archetypical Class I Aldolase by Directed Evolution

Kunzendorf, A., Xu, G., Van Der Velde, J. J. H., Rozeboom, H. J., Thunnissen, A.-M. W. H. & Poelarends, G. J., 5-Nov-2021, In: ACS Catalysis. 11, 21, p. 13236-13243 7 p.

Research output: Contribution to journal › Article › Academic › peer-review

Using Mutability Landscapes To Guide Enzyme Thermostabilization

Guo, C., Ni, Y., Biewenga, L., Pijning, T., Thunnissen, A.-M. W. H. & Poelarends, G. J., 5-Jan-2021, In: ChemBioChem. 22, 1, p. 170-175 7 p.

Research output: Contribution to journal › Article › Academic › peer-review

Cofactor Binding Dynamics Influence the Catalytic Activity and Selectivity of an Artificial Metalloenzyme

Villarino, L., Chordia, S., Alonso-Cotchico, L., Reddem, E., Zhou, Z., Thunnissen, A. M. W. H., Maréchal, J.-D. & Roelfes, G., 18-Sept-2020, In: ACS Catalysis. 10, 20, p. 11783-11790 8 p.

Research output: Contribution to journal › Article › Academic › peer-review

All (71) publications

Press/media

Kunstmatige intelligentie kraakt een van de grote raadsels in de biologie

Thunnissen, A.

16/09/2022

Press/Media: Expert Comment › Popular

3D ontdekkingstocht in de wereld van eiwitten

Thunnissen, A.

14/01/2017

Press/Media: Other › Popular

All (2) press/media

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