Dutch Protein Aggregation Network (DPAN)

Welcome on the website of the Dutch Protein Aggregation Network, which aims to bring together scientists working in the Netherlands on research into protein aggregation, in particular in context of human diseases. As a first step towards this aim, we will organize an initial DPAN symposium on November 30th 2023, in Amsterdam.

Symposium 2023

On November 30^th 2023 we welcome the Dutch protein aggregation research community to the inaugural symposium of our network DPAN, sponsored by NWO.
The symposium includes an array of presentations from researchers in our field, including a keynote presentation by Prof. Harm Kampinga. To join us, please register via the registration button below. Registration is free, and people are invited to submit a short abstract for poster submissions. The event will take place at the Vrije Universiteit (VU) in Amsterdam.

Registration

The registration of the meeting has been closed as we have reached capacity of the venue. Thanks for your interest!

Symposium program

(Note: Some details in the schedule below may be updated before the event.)
Downloadable symposium flyer with the program.

10:00 - 10:25              Registration & coffee

10:25 - 10:30              Introduction by organizers

10:30 - 11:30              Molecular Mechanisms regulating protein aggregation
Wiep Scheper (Amsterdam UMC) Neuron-specific proteostatic responses to tau aggregation
Monique Mulder (Leiden UMC)  Deciphering the role of the Ubiquitin Proteasome System in Huntington Disease
Anne Wentink (Leiden University)
Irem Bayraktaroglu (University of Groningen, GELIFES)

11:30 - 12:30              Structures of protein aggregates
Sander Woutersen (UvA) What infrared spectroscopy can tell us about protein aggregates
Wilma van de Berg (Amsterdam UMC) The assembly and structure of alpha-synuclein aggregates in synucleinopathies
Anouk Rijs (Vrije Universiteit Amsterdam)
Francesco Simone Ruggeri (Wageningen University)

12:30 - 13:00              Lunch break

13:00 - 14:15              Posters

14:15 – 14:55  Keynote speaker Harm Kampinga (Groningen UMC)
Chaperones and their fight against the protein aggregation avalanche

14:55 - 15:20              Coffee break

15:20 - 16:20              Protein aggregation disease modeling
 Jinte Middeldorp (BPRC) Protein Aggregates in non-human primate models of aging and COVID-19
Vered Raz (Leiden UMC) Nuclear aggregates in muscle pathology
Samantha Hughes (Vrije Universiteit Amsterdam)
Maurice Dekker (University of Groningen)

16:20 - 17:00              Therapeutic strategies targeting protein aggregation
Alberto Malerba (RHUL, UK) Gene therapy for Oculopharyngeal muscular dystrophy
Pavlo Zelina (Utrecht UMC)  Protein aggregation in ALS

17:00 - 17:05              Closing remarks

17:05 - 18:00              Drinks

Symposium location

The symposium will be in the auditorium of the O|2 building at the VU Amsterdam.
The venue is a 15 minutes walk from train station Amsterdam Zuid, right next to tram/bus stop "VUmc", and close to parking garages "P2 VUmc" and "P3 VU Campus. Address: De Boelelaan 1108, 1081HZ Amsterdam. [google maps]

Sponsors

We thank our sponsors: NWO, Thermo Fisher Scientific, Proteintech, Photothermal Spectroscopy corp and Ibidi.

About us

The organizers behind this initiative all study disease-related protein aggregation, but take different experimental approaches to do so. One goal of the DPAN network will be to offer and support an interdisciplinary perspective, while also facilitating and encouraging future collaborations across the boundaries of disciplines and disease types.

• Ronald Buijsen, LUMC

• Vered Raz, LUMC

• Steven Roeters, VUmc

• Aysegul Sapmaz, LUMC

• Patrick van der Wel, RUG

Questions/feedback

For questions about this initiative and the symposium, please feel free to contact Patrick van der Wel or any of the other organizers.