New Key Publication: Role of bile acid receptor FXR in development and function of brown adipose tissue

Highlights

• FXR is expressed in brown adipose tissue in mice and suppressed by cold.
• Mild adipose-specific overexpression of FXR causes whitening and fibrosis in brown adipose tissue.
• FXR hampers brown adipose tissue development and function.
• A humanized bile acid profile exacerbates brown adipose whitening in mice and suppresses Ucp1 and Dio2.

• FXR modulates BAT function and morphology at the level of tissue maintenance and development. FXR seems to act opposite and upstream to TGR5.

Authors:

• J.Yang
• H.D.de Vries
• A.Mayeuf-Louchart
• J.H.Stroeve
• V.W.Bloks
• M.Koehorst
• H.Duez
• B.Staels
• F.Kuipers
• T.van Zutphen

Read more: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids: https://www.sciencedirect.com/science/article/pii/S1388198122001470