A mouse tissue transcription factor atlas

Transcription factors (TFs) drive various biological processes ranging from embryonic development to carcinogenesis. Here, the group of Zhou and Qin developed a concatenated tandem array of consensus TF response elements (catTFRE) approach to profile the activated TFs in 24 adult and 8 fetal mouse tissues on proteome scale. This study provides a landscape of TFs in mouse tissues that can be used to elucidate transcriptional regulatory specificity and programming and as a baseline that may facilitate understanding diseases that are regulated by TFs.

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