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Prakash J, de Borst MH, van Loenen-Weemaes AM, Lacombe M, Opdam F, van Goor H, Meijer DKF, Moolenaar F, Poelstra K, Kok RJ. Cell-specific delivery of a transforming growth factor-beta type I receptor kinase inhibitor to proximal tubular cells for the treatment of renal fibrosis. Pharmaceutical Research, 2008; 25(10):2427-243
DOI
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van de Bovenkamp M, Groothuis GMM, Meijer DKF, Olinga P. Liver slices as a model to study fibrogenesis and test the effects of anti-fibrotic drugs on fibrogenic cells in human liver. Toxicology in Vitro, 2008; 22(3):771-778.320 DOI
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Schoemaker MH, Rots MG, Beljaars L, Ypma AY, Jansen PLM, Poelstra K, Moshage H, Haisma HJ. PDGF-receptor b -targeted adenovirus redirects gene transfer from hepatocytes to activated stellate cells. Molecular Pharmaceutics, 2008; 5(3):399-406. DOI
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Plazar J, Filipic M, Groothuis GMM. Antigenotoxic effect of Xanthohumol in rat liver slices. Toxicology in Vitro, 2008; 22(2):318-327. DOI
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Tarrus M, van der Sloot AM, Temming K, Lacombe M, Opdam F, Quax WJ, Molema G, Poelstra K, Kok RJ. RGD-avidin-biotin pretargeting to a (v) b (3) integrin enhances the proapototic activity of TNF a related apoptosis inducing ligand (TRAIL). Apoptosis, 2008; 13(2):225-235. DOI
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Hagens WI, Beljaars L, Mann DA, Wright MC, Julien B, Lotersztajn S, Reker-Smit C, Poelstra K. Cellular targeting of the apoptosis-inducing compound Gliotoxin to fibrotic rat livers. The Journal of Pharmacology and Experimental Therapeutics, 2008 ; 324(3):902-910. DOI
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van de Kerkhof EG, de Graaf IAM, Ungell A-LB, Groothuis GMM. Induction of metabolism and transport in human intestine: Validation of precision-cut slices as a tool to study induction of drug metabolism in human intestine in vitro. Drug Metabolism and Disposition, 2008; 36(3):604-613. DOI
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Olinga P, Elferink MGL, Draaisma AL, Merema MT, Castell JV, Pérez G, Groothuis GMM. Coordinated induction of drug transporters and phase I and II metabolism in human liver slices. European Journal of Pharmaceutical Sciences, 2008; 33(4-5):380-389. DOI
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Elferink MGL, Olinga P, Draaisma AL, Merema MT, Bauerschmidt S, Polman J, Schoonen WG, Groothuis GMM. Microarray analysis in rat liver slices correctle predicts in vivo hepatotoxicity. Toxicology and Applied Pharmacology, 2008; 229(3):300-309. DOI
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Prakash J, Poelstra K, van Goor H, Moolenaar F, Meijer DKF, Kok RJ. Novel therapeutic targets for the treatment of tubulointerstitial fibrosis. Current Signal Transduction Therapy, 2008; 3(2 ):97-111. DOI
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Dolman MEM, Fretz MM, Segers GJW, Lacombe M, Prakash J, Storm G, Hennink WE, Kok RJ. Renal targeting of kinase inhibitors. International Journal of Pharmaceutics , 2008; 364(2): 249-257. DOI
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Prakash J, de Borst MH, Lacombe M, Opdam F, Klok PA, van Goor H, Meijer DKF, Moolenaar F, Poelstra K, Kok RJ. Inhibition of renal Rho kinase attenuates ischemia/reperfusion-induced injury. Journal of the American Society of Nephrology, 2008; 19(11):2086-2097. Note: Two supplementary figures with legends. DOI
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Klassen LW, Thiele GM, Duryee MJ, Schaffert CS, DeVeney AL, Hunter CD, Olinga P, Tuma DJ. An in vitro method of alcoholic liver injury using precision-cut liver slices from rats. Biochemical Pharmacology, 2008; 76(3):426-436. DOI
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Fretz MM, Dolman MEM, Lacombe M, Prakash J, Nguyen TQ, Goldscheding R, Pato J, Storm G, Hennink WE, Kok RJ. Intervention in growth factor activated signaling pathways by renally targeted kinase inhibitors. Journal of Controlled Release, 2008 ; 132(3):200-207. DOI
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Temming K, Fretz MM, Kok RJ. Organ- and cell-type specific delivery of kinase inhibitors: A novel approach in the development of targeted drugs. Current Molecular Pharmacology , 2008; 1(1):1-12.
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