Publications 2002

Audouy SAL, de Leij LFMH, Hoekstra D, Molema G. In vivo characteristics of cationic liposomes as delivery vectors for gene therapy. Pharmaceutical research 19, 1599-1605. DOI

Bartsch M, Weeke-Klimp AH, Meijer DKF., Scherphof GL, Kamps JAAM. Massive and selective delivery of lipid-coated cationic lipoplexes of oligonucleotides targeted in vivo to hepatic endothelial cells. Pharmaceutical research 19, 676-680. DOI

Beljaars L, Bakker HI, van der Strate BWA, Smit C, Duijvestijn AM, Meijer DKF, Molema G. The Antiviral Protein Human Lactoferrin Is Distributed in the Body to Cytomegalovirus (CMV) Infection-Prone Cells and Tissues. Pharmaceutical research 19, 54-62. DOI

Beljaars L, Floris R, Berkhout B, Smit C, Meijer DKF, Molema G.  The influence of charge clustering on the anti-HIV-1 activity and in vivo distribution of negatively charged albumins. Biochemical Pharmacology 63, 1663-1673. DOI

Beljaars L, Meijer DKF, Poelstra K. Targeting hepatic stellate cells for cell-specific treatment of liver fibrosis. Frontiers in Bioscience 7, E214-E222. DOI

Bentala H, Verweij WR, Huizinga-Van der Vlag A, van Loenen-Weemaes AM, Meijer DKF  Poelstra K. Removal of phosphate from lipid as a strategy to detoxify lipopolysaccharide. Shock 18, 561-566. DOI

Berkhout B, van Wamel JLB, Beljaars L, Meijer DKF, Visser S, Floris R.  Characterization of the anti-HIV effects of native lactoferrin and other milk proteins and protein-derived peptides. Antiviral Research 55, 341-355. DOI

de Groot FMH, Broxterman HJ, Adams HPHM, van Vliet A, Tesser GI, Elderkamp YW, Schraa AJ, Kok RJ, Molema G, Pinedo HM, Scheeren HW.  Design, synthesis and biological evaluation of a dual tumor-specific motive containing integrin-targeted plasmin-cleavable doxorubicin prodrug. Molecular Cancer Therapeutics 1, 901-911.

de Kanter R, Monshouwer M, Meijer DKF, Groothuis GMM. Precision-cut organ slices as a tool to study toxicity and metabolism of xenobiotics with special references to non-hepatic tissues. Current Drug Metabolism 3, 39-59. DOI

de Kanter R, de Jager MH, Draaisma AL, Jurva JU, Olinga P, Meijer DKF, Groothuis GMM. Drug-metabolizing activity of human and rat liver, lung, kidney and intestine slices. Xenobiotica 32, 349-362. DOI

Everts M, Kok RJ, Ásgeirsdóttir SA, Melgert BN, Moolenaar TJM, Koning GA, van Luyn MJA, Meijer DKF, Molema G. Selective intracellular delivery of dexamethasone into activated endothelial cells using an E-selectin-directed immunoconjugate. The Journal of Immunology 168, 883-889.

Haas M, Moolenaar F, Elsinga A, van der Wouden EA, de Jong PE, Meijer DKF, de Zeeuw D.  Targeting of Doxorubicin to the Urinary Bladder of the Rat Shows Increased Cytotoxicity in the Bladder Urine Combined With An Absence of Renal Toxity. Journal of Drug Targeting 10, 81-89. DOI

Hooiveld GJEJ, Heegsma J, van Montfoort JE, Jansen PLM, Meijer DKF, Müller M.  Stereoselective transport of hydrophilic quaternary drugs by human MDR1 and rat Mdr1b P-glycoproteins. British Journal of Pharmacology 135, 1685-1694. DOI

Kok RJ, Schraa AJ, Bos EJ, Moorlag HE, Àsgeirsdóttir SA, Everts M, Meijer DKF, Molema G. Preparation and functional evaluation of RGD-modified proteins as a_vb₃ integrin directed therapeutics. Bioconjugate Chemistry 13, 128-135. DOI

Kok RJ, Haverdings RFG, Grijpstra F, Koiter J, Moolenaar F, de Zeeuw D, Meijer DKF. Targeting of Captopril to the Kidney Reduces Renal Angiotensin-Converting Enzyme Activity without Affecting Systemic Blood Pressure. The Journal of Pharmacology and Experimental Therapeutics 301, 1139-1143. DOI

Kok RJ, Everts M, Ásgeirsdóttir SA, Meijer DKF, Molema,G. Cellular handling of a dexamethasone-anti-E-selectin immunoconjugate by activated endothelial cells: comparison with free dexamethasone. Pharmaceutical research 19, 1730-1735. DOI

Kroesen BJ, Hut P, McLaughlin PMJ, Schuilenga-Hut PHL, Jacobs SC, Molema G, Helfrich W, de Leij LFMH. Tumor-targeted immune complex formation: effects on myeloid cell activation and tumor-directed immune cell migration. Int. J. Cancer 98, 857-863. DOI

Kuipers ME, Heegsma J, Bakker HI, Meijer DKF, Swart PJ, Frijlink EW, Eissens AC, de Vries-Hospers HG, van den Berg JJM. Design and Fungicidal Activity of Mucoadhesive Lactoferrin Tablets for the Treatment of Orapoharyngeal Candidosis. Drug Delivery 9, 31-38. DOI

Kuipers ME, Beljaars L, van Beek N, de Vries HG, Heegsma J, van den Berg JJM, Meijer,D.K.F. and Swart,P.J. Conditions influencing the in vitro antifungal activity of lactoferrin combined with antimycotics against clinical isolates of Candida: impact on the development of buccal preparations of lactoferrin. APMIS 110, 290-298. DOI

Meijer DKF van Montfoort JE. Interactions of cationic drugs and cardiac glycosides at the hepatic uptake level: studies in the rat in vivo, isolated perfused rat liver, isolated rat hepatocytes and oocytes expressing oatp2. Archives of Pharmacal Research 25, 397-415.

Molema G.  Tumor vasculature directed drug targeting: applying new technologies and knowledge to the development of clinically relevant therapies. Pharmaceutical research 19, 1251-1258. DOI

Schiffelers RM, Molema G, ten Hagen TLM, Janssen APCA, Schraa AJ, Kok RJ, Koning GA, Storm G. Ligand-targeted liposomes directed against pathological vasculature. Journal of Liposome Research 12, 129-135. DOI

Schiffelers RM, Molema G, ten Hagen TLM, Janssen APCA, Schraa AJ, Kok RJ, Koning GA, Storm G. Targeting of liposomes to angiogenic endothelial cells. Cellular & Molecular Biology Letters 7, 255.

Schoemaker MH, Ross JE, Homan M, Trautwein C, Liston P, Poelstra K, van Goor H, Jansen PLM, Moshage H.  Cytokine regulation of pro- and anti-apoptotic genes in rat hepatocytes: NF-kappaB-regulated inhibitor of apoptosis protein 2 (cIAP2) prevents apoptosis. Journal of Hepatology 36, 742-750. DOI

Schraa AJ, Kok RJ, Berendsen AD, Moorlag HE, Bos EJ, Meijer DKF, de Leij LFMH, Molema G. Endothelial cells internalize and degrade RGD-modified proteins developed for tumor vasculature targeting. Journal of controlled release 83, 241-251. DOI

Schraa AJ, Kok RJ, Moorlag HE, Bos EJ, Proost JH, Meijer DKF, de Leij LFMH, Molema,G.  Targeting of RGD-modified proteins to tumor vasculature: a pharmacokinetic and cellular distribution study. Int. J. Cancer 102, 469-475 DOI

Haas M, Moolenaar F, Meijer DKF, de Zeeuw D. Specific drug delivery to the kidney cardiovascular. Drugs and Therapy 16, 489-496 DOI

Verhoeven CHJ, Van Munster TTM, Groothuis GMM, Vos RME, Rietjens IMCM. Identification of the human P450 enzymes involved in the in vitro metabolism of the synthetic steroidal hormones org 4060 and org 30659. Xenobiotica 32, 109-118 DOI

Ásgeirsdóttir SA, Werner N, Harms G, van den Berg A, Molema G.  Analysis of in vivo endothelial cell activation applying RT-PCR following endothelial cell isolation by laser dissection microscopy. Annals of the New York Academy of Science 973, 586-589. (Conference report, Luxembourg January 30 - February 2 2002)

Schraa AJ, Everts M, Kok RJ, Ásgeirsdóttir SA, Meijer DKF, de Leij LFMH, and Molema G. Development of vasculature targeting strategies for the treatment of cancer and chronic inflammatory diseases. In: Biotechnology Annual Review, eds. El-Gewely, MR, volume 8, 133-165. Elsevier Science, Amsterdam

Beljaars L, van der Strate BWA, Meijer DKF, Swart P, Kuipers M,  Molema I, Floris R, Berkhout B.  Natural and charge-modified proteins for viral infection therapy. Industrial Proteins 10, 17-19.

Groothuis GMM. Slice technologie: ADME/Tox studies in plakjes humaan weefsel. Conceptuur 33[December 2002], 6-8. 

Molema G. Selectieve farmacologische interventie van endotheelcellen ter behandeling van chronische ontstekingsziekten en tumorgroei. Nederlandse Vereniging Voor Pathologie bulletin 11, 15-17.

Moolenaar F. Slaapmiddelengebruik een getolereerde epidemie? Foliolum 16[1], 17-19.

de Kanter R, Groothuis GMM.   Human and rat organ slices: a tool to study drug metabolism and toxicity. NCA Newsletter 13, 7-8.