PhD defence R.H. (Martijn) Zwinderman

Deacetylase inhibitors & histone inheritance.

The rules governing the distribution of histones to two daughter chromatids have long been the subject of speculation. However, in Martijn Zwinderman's thesis 'Deacetylase inhibitors and histone inheritance' it becomes clear that histone distribution is inherently asymmetric. Moreover, inversion of the asymmetric distribution of new histones from the lagging to the leading strand is observed during replication stress. These findings have implications for how epigenetic information is propagated through cell divisions and provide a basis for the connection between replication stress and epigentic alterations in disease.

Promotores: Prof.dr. F.J. Dekker and Prof.dr. H.J. Haisma