PhD defence S. (Sara) Russo

Macrophage metabolic reprogramming in chronic diseases

Chronic obstructive pulmonary disease (COPD) and diabetes are prevalent chronic conditions marked by persistent airflow limitation and high blood sugar levels, respectively. Both involve chronic inflammation characterized by pro-inflammatory cytokines impacting tissues, particularly through macrophages, key immune cells. This inflammation alters energy metabolism, affecting gene expression and cellular energy processes like glycolysis and fatty acid oxidation. Understanding these interactions is crucial for targeted therapies.

The thesis of Sara Russo explores macrophages' role in chronic inflammation across various tissues, focusing on obesity and type 2 diabetes in Chapter 2. It discusses macrophage phenotypes, metabolic variations, and characterization methods. Chapter 3 examines KDAC inhibitors' effects on macrophages, suggesting potential therapeutic benefits for COPD by reducing inflammation. Chapter 4 explores how collagen morphology influences macrophage behavior and metabolism, highlighting their adaptability to tissue environments.Overall, the thesis underscores macrophages' diverse metabolic adaptations in chronic conditions and their potential as therapeutic targets. It advocates for comprehensive characterization techniques like single-cell metabolomics and integrated multi-omics approaches to identify crucial regulators and targets for tailored treatments. In conclusion, understanding macrophage behavior offers insights into alleviating chronic inflammation and improving patient outcomes.

Promotores prof. dr. R.P.H. Bischoff, prof. dr. B.N. (Barbro) Melgert