PhD defence M. Konstantinidou

Multicomponent reactions, applications in medicinal chemistry & new modalities in drug discovery

The aim of the dissertation of Markella Konstantinidou is to discuss new targets, to apply multicomponent reaction chemistry on scaffolds significant for medicinal chemistry applications and to implement new modalities in drug design and medicinal chemistry. In particular, the protein-protein interaction of PD-1/PD-L1 is discussed regarding its significance in the field of immuno-oncology. Moreover, multicomponent reaction methodologies are discussed, as a valuable tool to access natural product analogues and heterocycles of great significance in drug discovery. The last part of the thesis focuses on the new modality of proteolysis targeting chimeras (PROTACs) and their applications on cancer-related and Parkinson-related targets.

Promotores: Prof.dr. A.S.S. Dömling and Prof.dr. T.A. Holak