Eva van den Berg, PhD

MSc: Biology, Free University of Amsterdam

PhD: Order and complexity in renal cell tumors.  A cytogenetic, molecular genetic and histopathological study, University of Groningen, 1993

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Dr. Eva van den Berg-de Ruiter is an associate professor in the Dept of Medical Genetics at the University Medical Center Groningen. She studied biology at the Free University of Amsterdam and the University of Nijmegen and obtained her PhD degree at the University of Groningen, where she works as a clinical cytogeneticist. Her research work focusses on the cytogenetics of renal cell carcinoma, soft tissue sarcomas, and hematological malignancies.

Current project: Identification and functional analysis of renal cell cancer tumour suppressor genes from the short arm of chromosome 3,

Keywords: renal cell cancer, soft tissue sarcomas, solid tumors, cytogenetics, genomics, genetic diagnostics leukemias and lymphomas

Recent publications  

• Targeted sequencing by proximity ligation for comprehensive variant detection and local haplotyping. de Vree PJ, de Wit E, ... Sikkema-Raddatz B, van den Berg E, van der Vlies P, ... de Laat W. Nat Biotechnol. 2014 Oct;32(10):1019-25. doi: 10.1038/nbt.2959.
• Identification of prognostic relevant chromosomal abnormalities in chronic lymphocytic leukemia using microarray-based genomic profiling. Stevens-Kroef MJ, van den Berg E, Olde Weghuis D, Geurts van Kessel A, Pfundt R, Linssen-Wiersma M, Benjamins M, Dijkhuizen T, Groenen PJ, Simons A. Mol Cytogenet. 2014 Jan 9;7(1):3. doi: 10.1186/1755-8166-7-3.
• A single center analysis of nucleophosmin in acute myeloid leukemia: value of combining immunohistochemistry with molecular mutation analysis. Woolthuis CM, Mulder AB, Verkaik-Schakel RN, Rosati S, Diepstra A, van den Berg E, Schuringa JJ, Vellenga E, Kluin PM, Huls G. Haematologica. 2013 Oct;98(10):1532-8. doi: 10.3324/haematol.2012.079806.
• Azacitidine might be beneficial in a subgroup of older AML patients compared to intensive chemotherapy: a single centre retrospective study of 227 consecutive patients. van der Helm LH, Scheepers ER, Veeger NJ, Daenen SM, Mulder AB, van den Berg E, Vellenga E, Huls G. J Hematol Oncol. 2013 Apr 16;6:29. doi: 10.1186/1756-8722-6-29.
• The entire miR-200 seed family is strongly deregulated in clear cell renal cell cancer compared to the proximal tubular epithelial cells of the kidney. Duns G, van den Berg A, van Dijk MC, van Duivenbode I, Giezen C, Kluiver J, van Goor H, Hofstra RM, van den Berg E, Kok K. Genes Chromosomes Cancer. 2013 Feb;52(2):165-73. doi: 10.1002/gcc.22016
• Targeted exome sequencing in clear cell renal cell carcinoma tumors suggests aberrant chromatin regulation as a crucial step in ccRCC development. Duns G, Hofstra RM, Sietzema JG, Hollema H, van Duivenbode I, Kuik A, Giezen C, Jan O, Bergsma JJ, Bijnen H, van der Vlies P, van den Berg E, Kok K. Hum Mutat. 2012 Jul;33(7):1059-62. doi: 10.1002/humu.22090. Epub 2012 Apr 30.

• Results of a randomized trial in children with Acute Myeloid Leukaemia: medical research council AML12 trial. Gibson BE, Webb DK, Howman AJ, De Graaf SS, Harrison CJ, Wheatley K; United Kingdom Childhood Leukaemia Working Group and the Dutch Childhood Oncology Group. Br J Haematol. 2011 155(3):366-76.
• Microarray-based genomic profiling as a diagnostic tool in acute lymphoblastic leukemia. Simons A, Stevens-Kroef M, El Idrissi-Zaynoun N, van Gessel S, Weghuis DO, van den Berg E, Waanders E, Hoogerbrugge P, Kuiper R, van Kessel AG. Genes Chromosomes Cancer. 2011 50(12):969-81.
• Gene expression profiling in the leukemic stem cell-enriched CD34+ fraction identifies target genes that predict prognosis in normal karyotype AML. de Jonge HJ, Woolthuis CM, Vos AZ, Mulder A, van den Berg E, Kluin PM, van der Weide K, de Bont ES, Huls G, Vellenga E, Schuringa JJ. Leukemia. 2011 25(12):1825-33.

• Van den Berg E and Störkel S. 2004. Kidney: Clear cell renal cell carcinoma. Atlas Genet Cytogenet Oncol Haematol. 

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