Top Recent Papers by Cisca Wijmenga

Systematic annotation of celiac disease loci refines pathological pathways and suggests a genetic explanation for increased interferon-gamma levels
V Kumar, J Gutierrez-Achury, K Kanduri, R Almeida, B Hrdlickova et al. Human molecular genetics, 2014. ddu453

Romanos J, Rosén A, Kumar V, Trynka G, Franke L, Szperl A, Gutierrez-Achury J, van Diemen CC, Kanninga R, Jankipersadsing SA, Steck A, Eisenbarth G, van Heel DA, Cukrowska B, Bruno V, Mazzilli MC, Núñez C, Bilbao JR, Mearin ML, Barisani D, Rewers M, Norris JM, Ivarsson A, Boezen HM, Liu E, Wijmenga C; PreventCD Group.
Improving coeliac disease risk prediction by testing non-HLA variants additional to HLA variants Gut. 2013 Jun 7. [Epub ahead of print] PubMed PMID: 23704318. Free article

Zhernakova A, Withoff S, Wijmenga C.
Clinical implications of shared genetics and pathogenesis in autoimmune diseases Nat Rev Endocrinol. 2013 Aug 20. doi: 10.1038/nrendo.2013.161. [Epub ahead of print] Abstract

Ricaño-Ponce I, Wijmenga C.
Mapping of immune-mediated disease genes Annu Rev Genomics Hum Genet. 2013;14:325-53. Abstract

Boomsma DI, Wijmenga C, Slagboom EP, Swertz MA, Karssen LC, Abdellaoui A, Ye K, Guryev V, Vermaat M, van Dijk F, Francioli LC, Jan Hottenga J, Laros JF, Li Q, Li Y, Cao H, Chen R, Du Y, Li N, Cao S, van Setten J, Menelaou A, Pulit SL, Hehir-Kwa JY, Beekman M, Elbers CC, Byelas H, de Craen AJ, Deelen P, Dijkstra M, den Dunnen JT, de Knijff P, Houwing-Duistermaat J, Koval V, Estrada K, Hofman A, Kanterakis A, Enckevort DV, Mai H, Kattenberg M, van Leeuwen EM, Neerincx PB, Oostra B, Rivadeneira F, Suchiman EH, Uitterlinden AG, Willemsen G, Wolffenbuttel BH, Wang J, de Bakker PI, van Ommen GJ, van Duijn CM.
The Genome of the Netherlands: design, and project goals Eur J Hum Genet. 2013 May 29. Abstract

Smeekens SP, Ng A, Kumar V, Johnson MD, Plantinga TS, van Diemen C, Arts P, Verwiel ET, Gresnigt MS, Fransen K, van Sommeren S, Oosting M, Cheng SC, Joosten LA, Hoischen A, Kullberg BJ, Scott WK, Perfect JR, van der Meer JW, Wijmenga C, Netea MG, Xavier RJ. (2013)
Functional genomics identifies type I interferon pathway as central for host defense against Candida albicans Nat Commun. 4:1342. Free PMC article

Kumar V, Westra HJ, Karjalainen J, Zhernakova DV, Esko T, Hrdlickova B, Almeida R, Zhernakova A, Reinmaa E, Võsa U, Hofker MH, Fehrmann RS, Fu J, Withoff S, Metspalu A, Franke L, Wijmenga C.
Human disease-associated genetic variation impacts large intergenic non-coding RNA expression PLoS Genet 2013;9(1):e1003201. IF 8.7. Free PMC article

Kumar V, Wijmenga C, Withoff S.
From genome-wide association studies to disease mechanisms: celiac disease as a model for autoimmune diseases. Semin Immunopathol. 2012;34(4):567-80. Free PMC article

Dolmans GH, Werker PM, de Jong IJ, Nijman RJ; LifeLines Cohort Study, Wijmenga C, Ophoff RA.
WNT2 locus is involved in genetic susceptibility of Peyronie's disease J Sex Med. 2012;9(5):1430-4. Abstract

Netea MG, Wijmenga C, O'Neill LA.
Genetic variation in Toll-like receptors and disease susceptibility Nat Immunol 2012;13(6):535-42. IF 26.0. Abstract

Trynka G, Hunt KA, Bockett NA, Romanos J, Mistry V, Szperl A, Bakker SF, Bardella MT, Bhaw-Rosun L, Castillejo G, de la Concha EG, AlmeidaRC, Dias KM, van DiemenCC, Dubois PCA, DuerrRH, EdkinsS, Franke L, FransenK, GutierrezJ, Heap GAR, Hrdlickova B, Hunt S, Plaza Izurieta L, IzzoV, Joosten LAB, Langford C, MazzilliMC, Mein CA, Midah V, Mitrovic M, Mora B, Morelli M, Nutland S, NúñezC, Onengut-GumuscuS, Pearce K, PlatteelM, PolancoI, PotterS, Ribes-Koninckx C, Ricaño-PonceI, Rich SS, Rybak A, Santiago JL, Senapati S, Sood A, Szajewska H, Troncone R, VaradéJ, Wallace C, Wolters VM, Zhernakova A, CEGEC (Spanish Consortium on the Genetics of Coeliac Disease), PreventCD Study Group, Wellcome Trust Case Control Consortium, Thelma B.K., Cukrowska B, Urcelay E, Bilbao JR, Mearin ML, Barisani D, Barrett JC, Plagnol V, Deloukas P, Wijmenga C^#, van Heel DA^#
Dense genotyping reveals and localizes multiple common and rare variant association signals in celiac disease Nat Genet 2011;43(12): 1193-201. IF 36.4; NoC 108. Free PMC article

Dolmans GH, Werker PM and the Dutch Dupuytren Study Group, Hennies HC and the German Dupuytren Study Group, Furniss D, Festen EA, Franke L, Becker K, van der Vlies P, Wolffenbuttel BH and the LifeLines Cohort Study, Tinschert S, Toliat MR, Nothnagel M, Franke A, Klopp N, Wichmann H-E, Nürnberg P, Henk Giele H and the BSSH GODD Consortium, Ophoff RA, Wijmenga C.
WNT-signaling and Dupuytren’s disease. N Engl J Med 2011;365(4):307-17. IF 53.3; NoC 37. Free article

Zhernakova A, Stahl EA,Trynka G, Raychaudhuri S, Festen E, Franke L, Westra HJ, Fehrmann RSN, Kurreeman FAS, Thomson B, Gupta N, Romanos J, McManus R, Ryan AW, Turner G, Brouwer E, Posthumus MD, Remmers EF, Greco L, Toes R, Grandone E, Mazzilli MC, Rybak A, Cukrowska B, Coenen MJH, Randstake TRDJ, van Riel PLCM, Li Y, de Bakker PIW, Gregersen PK, Worthington J, Siminovitch KA, Klareskog L, Huizinga TJW, Wijmenga C^#, Plenge RM^#.
Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci PloS Genetics 2011;7(2):e1002004. IF 8.7; NoC 97. Free PMC article

Zhernakova A, van Diemen CC, Wijmenga C.
Detecting shared pathogenesis from the shared genetics of immune-related diseases. Nature Rev Genet 2009;10(1):43-55. IF 38.01; NoC 224. Abstract

Hunt KA, Zhernakova A, Turner G, Heap GAR, Franke L, Bruinenberg M, Romanos J, Dinesen LC, Ryan AW,Panesar D, Gwilliam R, Takeuchi F, McLaren WM, Holmes GFT, Howdle PD, Walters GRF, Sanders DS, Playford RJ, Trynka G, Mulder CJJ, Mearin ML, Verbeek WHM, Trimble V, Stevens FM, O'Morain C, Kennedy NP, Kelleher D, Pennington DJ, Strachan DP, McArdle WL, Mein CA, Wapenaar MC, Deloukas P, McGinnis R, McManus R^#, Wijmenga C^#, van Heel DA^#.
Newly identified genetic risk variants for celiac disease related to the immune response Nature Genet 2008;40(4):395-402. IF 35.2; NoC 341. Free PMC article
Must read Faculty of 1000 Medicine

Zhernakova A, Alizadeh BZ, Bevova M, van Leeuwen MA, Coenen MJ, Franke B, Franke L, Posthumus M, van Heel D, van der Steege G, Radstake TR, Barrera P, Roep BO, Koeleman BP, Wijmenga C.
Novel association in chromosome 4q27 region to rheumatoid arthritis and confirmation to type 1 diabetes points to a general locus for autoimmune diseases Am J Hum Genet 2007;81(6):1284-8. IF 11.7; NoC 152. Free PMC article

Van Heel DA, Franke L, Hunt KA, Gwilliam R, Zhernakova A, Inouye M, Wapenaar MC, Barnardo MC, Bethel G, Holmes GK, Feighery C, Jewell D, Kelleher D, Kumar P, Travis S, Walters JRF, Sanders DS,Howdle P, Swift J, Playford R, McClaren W, Mearin ML, Mulder CJ, McManus R, McGinnis R, Cardon L, Deloukas P, Wijmenga C.
A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21 Nature Genet 2007;39(7):827-9. IF 35.2; NoC 381. Free PMC article
Recommended by Faculty of 1000 Biology

Franke F, van Bakel H, Fokkens L, de Jong E, Petersen M-E, Wijmenga C.
Reconstruction of a functional human gene network, with an application for prioritizing positional candidate genes Am J Hum Genet 2006;78(6):1011-25. IF 10.6; NoC 356. Free PMC article