Targeted delivery of TRAIL for immunotherapy of ovarian cancer
PhD ceremony: Mr. M. de Bruyn, 11.00 uur, Academiegebouw, Broerstraat 5, Groningen
Dissertation: Targeted delivery of TRAIL for immunotherapy of ovarian cancer
Promotor(s): prof. A.G.J. van der Zee, prof. L.F.H.M. de Leij
Faculty: Medical Sciences
In this thesis, the concept of tumour-targeted delivery of sTRAIL was further developed in preclinical studies with an emphasis on eliminating metastasis and disseminated disease. In addition, this tumour cell-targeted approach was adapted to an immune cell-targeted approach with the goal of augmenting anti-tumour activity of T-cells. Selective delivery of high levels of TRAIL to the cell surface of T-cells, a key tumoricidal immune effector cell population, strongly augments their anti-tumour activity. This novel approach proved to be highly effective towards a host of different tumour cell types, including ovarian cancer.
| Last modified: | 13 March 2020 01.02 a.m. |
More news
-
27 August 2024
UMCG gaat onderzoeksfaciliteiten beschikbaar stellen voor geneesmiddelenontwikkeling
Om de beschikbaarheid en effectiviteit van geneesmiddelen in Nederland te verbeteren gaat het UMCG het bedrijf G² Solutions opzetten. Dit bedrijf moet ervoor gaan zorgen dat belangrijke technologische ontwikkelingen op het gebied van DNA sequencing...
-
17 July 2024
Veni-grants for ten researchers
The Dutch Research Council (NWO) has awarded a Veni grant of up to €320,000 each to ten researchers of the University of Groningen and the UMCG. The Veni grants are designed for outstanding researchers who have recently gained a PhD.
-
16 July 2024
Medicine still subjects to male bias
Aranka Ballering studied the course of illness in people with common symptoms. One of the most striking findings to emerge from her research was that on average, women have a different – and less extensive – course of illness than men.