ABC transporters and cholesterol metabolism in acute myeloid leukemia
PhD ceremony: Ms. S.D.P.W.M. de Jonge-Peeters, 13.15 uur, Academiegebouw, Broerstraat 5, Groningen
Title: ABC transporters and cholesterol metabolism in acute myeloid leukemia
Promotor(s): prof. E. Vellenga, prof. E.G.E. de Vries, prof. F. Kuiper
Faculty: Medical Sciences
Acute myeloid leukemia (AML) is a malignant disease of hematopoietic bone marrow stem cells. Knowledge about the defence mechanisms of bone marrow stem cells against chemotherapy may provide important new targets to improve antileukemic treatment.In this thesis ATP binding Cassette (ABC) transporter expression and function in different hematopoietic cell fractions were studied. Result show that some ABC transporters, which are known to be involved in cholesterol metabolism, are highly expressed in the primitive cell fraction of hematopoietic cells. Subsequently, in vitro studies showed that, for a subgroup of AML patients, malignant cells became more sensitive to standard chemotherapeutic treatment when used with commonly used cholesterol lowering drugs (statins).
| Last modified: | 13 March 2020 01.11 a.m. |
More news
-
17 July 2024
Veni-grants for ten researchers
The Dutch Research Council (NWO) has awarded a Veni grant of up to €320,000 each to ten researchers of the University of Groningen and the UMCG. The Veni grants are designed for outstanding researchers who have recently gained a PhD.
-
16 July 2024
Medicine still subjects to male bias
Aranka Ballering studied the course of illness in people with common symptoms. One of the most striking findings to emerge from her research was that on average, women have a different – and less extensive – course of illness than men.
-
10 June 2024
Swarming around a skyscraper
Every two weeks, UG Makers puts the spotlight on a researcher who has created something tangible, ranging from homemade measuring equipment for academic research to small or larger products that can change our daily lives. That is how UG...