CD20 targeting and beyond
PhD ceremony: Ms. A.J. Stel, 14.45 uur, Academiegebouw, Broerstraat 5, Groningen
Thesis: CD20 targeting and beyond
Promotor(s): prof. L.F.M.H. de Leij, prof. J.C. Kluin-Nelemans
Faculty: Medical Sciences
The aim of this thesis is to characterize the immunobiological features of the protein CD20 in relation to its effectiveness as a target for therapy of B-cell malignancies. CD20 probably has a biological function in regulating and amplifying the signals of related receptor molecules like Fas or HLA-DR thereby facilitating B-cell processes such as immune synapse formation and receptor signaling. Expansion of knowledge about the biological function of CD20 can support the development of new therapeutic options in treatment of B-cell malignancies.
| Last modified: | 13 March 2020 01.14 a.m. |
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