PhD Position in Biophysics (V24.0413)

The Heinemann Lab at the University of Groningen (Netherlands) aims to understand how cellular metabolism functions and how metabolism controls other cellular processes.

The lab has recently found that cellular metabolism does not operate beyond a certain Gibbs energy dissipation rate (Niebel et al, 2019, Nature Metabolism). This observation could explain why cancer cells use a particular mode of metabolism. We are now highly interested to uncover the molecular mechanism that is responsible for this thermodynamic limit. Here, we hypothesize that enzymes during their catalysis get actively displaced in space, inducing increased molecular motion in the cell and mixing up the cytoplasm. We have described this hypothesis in a recent perspective article (Losa et al, 2022, Molecular Systems Biology).

In this project, we like to explore the above mentioned hypothesis. To this end, we will use the bacterium E. coli as a model and will perform highly sophisticated experiments with super-resolution microscopy and dynamic particle tracking techniques to measure diffusion rates in cells. Furthermore, in model-based experimental analyses, we aim to determine the Gibbs energy dissipation rates under different metabolic conditions. Together, this will hopefully give us further insights.

Exploring how an active metabolism as an out-of-equilibrium system induces intracellular motion is not only a great scientific adventure, with the potential to open up a new avenue how dynamic cellular metabolism might control cellular processes (i.e. through motion), but it also harbors significant potential for medicine and biotechnology, where metabolism plays a key role.

The candidate needs to have a Master degree.

The two most important selection criteria for this position are (i) the "motivation" and (ii) the "creativity" of the candidate. With the right motivation, everything can be learned, meaning that the candidate does not need any particular prior skills/qualifications besides having a Master degree in any of the above mentioned disciplines. Our lab members come from many different disciplines and we have a great culture of learning and teaching each other.

This project has a focus on biophysical experiments (e.g. single-particle tracking microscopy). No specific prior experience in these experimental techniques is required, as there is sufficient expertise present in the lab, offering an opportunity to learn these techniques. We are convinced that excellent candidates with the right motivation can learn everything.

We offer you in accordance with the Collective Labour Agreement for Dutch Universities:

• A salary of € 2,770 gross per month in the first year, up to a maximum of € 3,539 gross per month in the fourth and final year for a full-time working week
• A holiday allowance of 8% gross annual income and an 8.3% year-end bonus
• A full-time position (1.0 FTE). The successful candidate will first be offered a temporary position of one year with the option of renewal for another three years.
• Prolongation of the contract is contingent on sufficient progress in the first year to indicate that a successful completion of the PhD thesis within the next three years is to be expected.
• A PhD training programme is part of the agreement and the successful candidate will be enrolled in the Graduate School of Science and Engineering.

You may apply for this position until 15 September 2024 23:59 Dutch Local Time (CEST) / before 16 September 2024 by means of the application form (click on "Apply" below on the advertisement on the university website).

Applications should include:

• Letter of motivation
• CV
• Transcripts from your bachelor’s and master’s degree.

Every incoming application is immediately being looked at. Good candidates are being contacted to schedule a first brief online interview (even before the application deadline), followed by more in-depth discussions and an invitation to come to Groningen for a day or two, to allow for discussions with the current lab members.

The preferred starting date is between December 1st 2024 and March 1st 2025, but this is flexible and up to negotiation.

For a successful, productive and a joyful PhD time it is important that everything fits and is right. This entails that there is good communication between the PhD student and the group leader and the group members, that there is a joint view on ambition, etc. Thus, in the hiring process, we make sure that we take sufficient amount of time to make the right decision. The decisions has to be right for us as a research group and also for the candidate.

The University of Groningen strives to be a university in which students and staff are respected and feel at home, regardless of differences in background, experiences, perspectives, and identities. We believe that working on our core values of inclusion and equality are a joint responsibility and we are constructively working on creating a socially safe environment. Diversity among students and staff members enriches academic debate and contributes to the quality of our teaching and research. We therefore invite applicants from underrepresented groups in particular to apply. For more information, see also our diversity policy webpage: https://www.rug.nl/about-ug/policy-and-strategy/diversity-and-inclusion/

Our selection procedure follows the guidelines of the Recruitment code (NVP): https://www.nvp-hrnetwerk.nl/nl/sollicitatiecode and European Commission's European Code of Conduct for recruitment of researchers: https://euraxess.ec.europa.eu/jobs/charter/code

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