Early clinical studies to explore candidate biomarkers in targeted cancer therapies
PhD ceremony: Ms. C.N.A.M. Oldenhuis, 12.45 uur, Academiegebouw, Broerstraat 5, Groningen
Dissertation: Early clinical studies to explore candidate biomarkers in targeted cancer therapies
Promotor(s): prof. J.A. Gietema, prof. E.G.E. de Vries, prof. S. de Jong
Faculty: Medical Sciences
Currently, much information is becoming available from tumor cell biology research, opening opportunities for the development of specifically tumor targeting agents. In this thesis we studied the safety, tolerability and pharmacokinetics of two novel targeted agents in phase 1 studies. An oral angiogenesis inhibitor and the apoptosis inducing agonistic antibody mapatumumab both appeared safe in combination with chemotherapy. No pharmacokinetic interactions were seen. Further studies on this combination are therefore warranted.
Last modified: | 13 March 2020 01.02 a.m. |
More news
-
29 May 2024
European joint Master’s degree programmes are among the top programmes
On 27 May, the EACEA in Brussels celebrated the fact that the first Erasmus Mundus Master’s degree programmes were launched twenty years ago.
-
27 May 2024
Four honorary doctorates awarded by the UG
On Friday, 24 May, the UG awarded four honorary doctorates to Dr Kate Crawford, Dr Tedros Ghebreyesus, Gerrit Hiemstra and Prof. Mariana Mazzucato. The presentation took place in the Aula of the Academy Building and was part of the university's...